ACTIV4a @ACTIV4a
Official account of the Accelerating COVID-19 Therapeutic Interventions and Vaccines Acute Inpatient Anti-Thrombotic Study (ACTIV-4a) Joined December 2020-
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>95% confidence in futility in non-critically #Covid_19 - @ACTIV4a still enrolling P2Y12 in critically ill patients - generating data at warp speed thanks to @NIHFunding @nih_nhlbi
>95% confidence in futility in non-critically #Covid_19 - @ACTIV4a still enrolling P2Y12 in critically ill patients - generating data at warp speed thanks to @NIHFunding @nih_nhlbi
Superb @UofT_DoM Grand Rounds by @ecgoligher & @PatrickLawlerMD on the background, statistical approach & interpretation of the adaptive Bayesian design multiplatform @ATTACC_COVID / @ACTIV4a / @remap_cap anticoag in COVID trial. nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…
In noncritically ill patients with #COVID19, anticoagulation increased the probability of survival to hospital discharge without organ support. nej.md/3jrrxJx #IDTwitter
Great international collaboration @remap_cap @ATTACC_COVID @ACTIV4a
Great international collaboration @remap_cap @ATTACC_COVID @ACTIV4a
The incredible efforts of so many have led to the publication of both #mpRCT papers reporting results of anticoagulation in #COVID19. @NEJM @ATTACC_COVID @remap_cap @ACTIV4a Most challenging/rewarding effort of my career nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…
Results of our therapeutic anticoagulation mpRCT with @ACTIV4a and @remap_cap is being live-streamed below. Results have now been published in the @NEJM Moderate state: bit.ly/3ioKptb Critically ill: bit.ly/3lxzn7c Editorial: bit.ly/3ltYnMj
Results of our therapeutic anticoagulation mpRCT with @ACTIV4a and @remap_cap is being live-streamed below. Results have now been published in the @NEJM Moderate state: bit.ly/3ioKptb Critically ill: bit.ly/3lxzn7c Editorial: bit.ly/3ltYnMj
The final presentation timed with a public report. Come find out how the trial was done & what the role of therapeutic anticoagulation is in hospitalized patients with COVID-19. @ATTACC_COVID @remap_cap @ACTIV4a @UM_RadyFHS @UHN @CCCTG_ @canvector @ASH_hematology @JustinTrudeau
The final presentation timed with a public report. Come find out how the trial was done & what the role of therapeutic anticoagulation is in hospitalized patients with COVID-19. @ATTACC_COVID @remap_cap @ACTIV4a @UM_RadyFHS @UHN @CCCTG_ @canvector @ASH_hematology @JustinTrudeau
Big night tomorrow night! Free livestream from 20:30 UTC criticalcarereviews.com Supported by @MyIntensiveCare
@RZarychanski @SCCM @ASH_hematology @UM_RadyFHS @CCCTG_ @ThrombosisCan @INVENT_VTE Looking forward to discussing these results next week. This will impact COVID-19 practice worldwide 🌐 @ATTACC_COVID @remap_cap @ACTIV4a @charlot_summers @ecgoligher @PatrickLawlerMD
For patients with #COVID19 receiving organ support in the ICU, #antiplatelet therapy with aspirin or P2Y12 inhibitor (which were found to be equivalent), was ineffective at improving death and organ support free days when compared to no #antiplatelet therapy. 1/8
Final results of the mpRCT now on preprint server. In non-critically ill patients with COVID-19 (n=2219), therapeutic-dose anticoagulation with heparins increases survival to hospital discharge with reduced use of organ support. medrxiv.org/content/10.110…
Just had our @ACTIV4a v1.1 protocol review - we hope to start randomizing to yes/no P2Y12i in hospitalized #COVID19 very soon!!@macky_neal @LucyKornblith @ATTACC_COVID @MaryCushmanMD @PatrickLawlerMD @statberry
In this free access @bmj_latest editorial we discuss - the changing views & practice of thromboprophylaxis in hospitalised patients with COVI-19 through the pandemic - the recent RCT interim evidence from @remap_cap @ATTACC_COVID & @ACTIV4a as to what is the best dose of LMWH
In this free access @bmj_latest editorial we discuss - the changing views & practice of thromboprophylaxis in hospitalised patients with COVI-19 through the pandemic - the recent RCT interim evidence from @remap_cap @ATTACC_COVID & @ACTIV4a as to what is the best dose of LMWH
@ToddNeale @connors_md @Erik_Klok_MD Was nice discussing thrombosis and antithrombotic Rx in #covid19 from the mpRCT between @ACTIV4a @ATTACC_COVID @remap_cap
@ATTACC_COVID A brief thread on interpreting organ support-free days as an endpoint for RCTs including @ATTACC_COVID @remap_cap @ACTIV4a Visit the simulator linked here to explore how the endpoint is influenced by its various components bit.ly/3oFZ57j
Progress is not only being made with #vaccines. It’s being made in finding effective ways to treat #COVID19 and improve outcomes. The latest on #bloodthinners and #colchicine on my blog. #NIH bit.ly/3cxsNZA
We are releasing the interim (final data coming and publication submission pending) data from our amazing mpRCT collaboration w/ @ATTACC_COVID @remap_cap to aid in clinician decision making on anticoagulants for #COVID19: nhlbi-connects.org/documents/mpRC… @nih_nhlbi @macky_neal
Early results of a worldwide trial, coordinated in part by researchers at Pitt, found that full doses of heparin, a blood thinner, were not only safe but also reduced the need for vital organ support, such as ventilation for COVID-19 patients. More here: bit.ly/3oemMDy
@ACTIV4a @AaronKornblith @UCSFchipper @UCSF_BCHSI @UCSFHospitals @UCSFSurgery I’d say that the real forces of nature are @ACTIV4a @remap_cap @ATTACC_COVID and their tireless, dedicated, brilliant, amazing leadership. Grateful for the opportunity to learn from and work alongside all of you.
Matthew D. Neal, MD @macky_neal
3K Followers 1K Following Vice Chair Academic Affairs @PittSurgery, Director Emergency General Surgery @UPMC, Director @pittttmrc, CMO @HaimaThr #hemostasis🩸 #thrombosis, Family man 1st
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remap-cap @remap_cap
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55.2M Followers 878 Following News tips? Share them here: https://t.co/ghL9OoYKMM>95% confidence in futility in non-critically #Covid_19 - @ACTIV4a still enrolling P2Y12 in critically ill patients - generating data at warp speed thanks to @NIHFunding @nih_nhlbi
Dear Followers I’m not sure what it means or what made it happen but THANK YOU 🙏
At axe bar - #hatchesandhops with the #platelet lab
Gorgeous slides explaining the coagulopathy of COVID-19 #whith session on COVID-19 with @MiddeldorpS @DJC6998 Thank you Elalamy Ismail
Superb @UofT_DoM Grand Rounds by @ecgoligher & @PatrickLawlerMD on the background, statistical approach & interpretation of the adaptive Bayesian design multiplatform @ATTACC_COVID / @ACTIV4a / @remap_cap anticoag in COVID trial. nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…
An incredible adventure with a global impact. The mpRCT was a great example of #teamwork and #partnership to improve clinical care in #COVID19 @ACTIV4a is now studying #P2Y12 inhibitors and will soon be studying P-selectin inhibition #crizalizumab
ACTIV-4a trial results, co-led by researchers at NYU Grossman, show that a full dose of blood thinner reduces the need for cardiovascular & respiratory support in moderately ill COVID-19 patients, but not in critically ill COVID-19 patients. Read more: bit.ly/2VyxmfK
@Lennie333 👍 More great work from @remap_cap (and @ATTACC_COVID @ACTIV4a)
📖New Literature Alert📖 2 large trials (combining @remap_cap, @ACTIV4a , and #ATTACC) on🩸therapeutic anticoagulation🩸 in 1). Critically ill and 2.) Non-critically ill patients were published in @NEJM.
I forgot to tweet this earlier, due to preparations for the @recovery_rs livestream Here is the unedited version of last nights @remap_cap @ATTACC_COVID @ACTIV4a anticoagulation in COVID-19 trial result presentation vimeo.com/583052884 The session begins at 1:30:16
@Yonatan_G_MD @ACTIV4a @ATTACC_COVID @remap_cap @Rutgers_NJMS @UnivHospNewark Was an incredible team effort!!! Hope this will be used to base clinical decision making.
Thank you @CancerCareMBFdn @Research_MB @SupportTheVic for supporting these landmark trials. The trials could not have started strongly without your vision and support. Manitoba's initial investment was leveraged to complete a global trial that established a new therapy for COVID
@macky_neal @NEJM @ATTACC_COVID @remap_cap @ACTIV4a Congrats all and special congratulations @macky_neal!!!!
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 shows no benefit in the fully reviewed paper from 3 RCTs looking at > 1000 patients nejm.org/doi/full/10.10…
In contrast reduction in organ support days see in those receiving therapeutic LMWH/UFH who were moderately ill with COVID-19 in final peer reviewed paper nejm.org/doi/full/10.10…
Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 shows no benefit in the fully reviewed paper from 3 RCTs looking at > 1000 patients nejm.org/doi/full/10.10…
@macky_neal @NEJM @ATTACC_COVID @remap_cap @ACTIV4a Grateful for your scientific and trial leadership @macky_neal amazing to work with you and all others involved in the mpRCT
In noncritically ill patients with #COVID19, anticoagulation increased the probability of survival to hospital discharge without organ support. nej.md/3jrrxJx #IDTwitter
Great international collaboration @remap_cap @ATTACC_COVID @ACTIV4a
And the manuscripts are online!
I am incredibly thankful to @PlateletDoc for the opportunity to be a part of this incredible group effort. Congratulations to @ACTIV4a @ATTACC_COVID @remap_cap A huge shout out to the Clinical Research Team at Rutgers led by Randall Teeter! @Rutgers_NJMS @UnivHospNewark
The incredible efforts of so many have led to the publication of both #mpRCT papers reporting results of anticoagulation in #COVID19. @NEJM @ATTACC_COVID @remap_cap @ACTIV4a Most challenging/rewarding effort of my career nejm.org/doi/full/10.10… nejm.org/doi/full/10.10…
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