Biotech Strategy @BiotechStrategy
🇺🇦 Biotech Strategy Blog provides commentary on #pharma #biotech new product development with focus on #oncology #ImmunoOnc #tcellrx (sub req'd) biotechstrategyblog.com Joined September 2013-
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Summit Therapeutics' ivonescimab Western reality check: Why HARMONi may underperform relative to expectations – not everything new is gaudy... tinyurl.com/bdda73b3
With Keytruda going off patent in a couple of years, what are Merck doing on the innovation front to replace it? It turns out quite a bit behind the scenes. Our latest interview has the skinny... tinyurl.com/743cppsc
The $SMMT HARMONi data for ivonescimab will be at #WCLC25 rather than #ESMO25 this year. What's store, why does it matter, and what can we discover from the competition? Turns out quite a bit! tinyurl.com/42tehmr3
Time to dissect a new development in metastatic melanoma for green lights & warning signs – and no, this is not about IO Biotech's miss: tinyurl.com/4un3tm6t
Would you go out on a limb for Celcuity's commercial success with their dual PI3K/mTOR inhibitor (gedatolisib) in HR+/HER2- breast cancer? There's plenty of red and green flags to consider here: tinyurl.com/32eewyc7
With a few early dropouts in this onco niche it might be tempting to think all is lost, but wait! There's a raft of next generation ADCs coming along the outside rail and they might well fare better than their predecessors... tinyurl.com/4yuyrhs8
With the rise of B7-H4 ADCs and T cell engagers, are these the best way to tackle a tricky target? Or is there an alternative approach we can consider? Time to explore the science and find out if it stands out from the crowd: tinyurl.com/59k3ck7w
Not all dreams become reality... when mooning at authority figures predictably lands you in trouble: tinyurl.com/43cuyu4k
How a much misunderstood subset of immune cells may turn out to be a key missing link in communication with cancer cells... A look at the cellular conductors: tinyurl.com/2c5mvjvy
New developments in CAR-T cell therapies... Finding the Yin & Yang balance in both Heme and Solid Tumour settings is tricky, yet highly desirable: tinyurl.com/2uf7n58b
The Great Protein Hunt – a look at how modern molecular glues are expanding the druggable universe: tinyurl.com/3brpjdb3
Armoured and dangerous – how next generation CAR-T cell therapies may give both CD19 CARs and CD20 T cell engagers a serious run for their money in advanced lymphomas: tinyurl.com/4cnj56zn
What if you could predict which molecules will cause toxicity before entering the clinic? One biotech thinks they've cracked the code which has plagued drug development for decades. Their early results are... unexpected. tinyurl.com/yfj5yhnj
A look at how far we have come since the CD19/CD22 CAR-T cell approach. Will dual CD19/CD20 CARs will offer both revved up responses and better mileage: tinyurl.com/34spu6rb
Protein degraders hit their stride – our latest report explores progress with 3 different targets to assesses the pros, cons, and opportunities. A few surprises are in store! tinyurl.com/yc6f58p5
Sometimes a class is so much more than numbers and stats. In this review we compare the performance of Menin inhibitors to the old Five Nations rugby tournament at #EHA25... What would you rather have - flashy, flamboyant, or cohesive? biotechstrategyblog.com/2025/06/more-t…
I thought it was intriguing to see Prof Schett's team were able to rescue one of the 2 relapses with a BCMA CAR-T cell therapy. Meanwhile, there is data from China in a post CD19 CAR setting too: nejm.org/doi/full/10.10… @ChrisHeery
This is fascinating- what an extraordinary detective story - congratulations
This is fascinating- what an extraordinary detective story - congratulations
In a nutshell... some progress to report with CAR-T cells and T cell engagers in autoimmune diseases from #EULAR25 biotechstrategyblog.com/2025/06/in-a-n…
Time for a trip of the beaten track to explore emerging targets and modalities in a cancer category, which hasn't had a lot of attention over the last decade. The good news? Things are finally changing! tinyurl.com/mry2jmy9
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