Rohit Joshi @RohitjoshiB
Postdoc @Penn # Chromatin remodelling# Nuclear Architecture# Cell mechanics#Stem cell biology#stem cell senescence. GBPUAT || JNU || @iitbombay || Philadelphia, PA Joined May 2018-
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Rohit Joshi retweeted
NEW STUDY: Epigenetic drift is redefined as “mesenchymal drift”, with aged cells undergoing EMT, typically a cell ID alteration in development & wound healing, not diseases. Drift is reversed by OSK(M) reprogramming! Another step forward 👏 @altos_labs cell.com/cell/fulltext/…
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Rohit Joshi retweeted
Why does cancer incidence increase with age? Is it the accumulation of mutations? Is it a declining immune system? Are there other factors? Both mutation accumulation and immune system decline correlate with age and support predictive models of cancer rates. 🧵
Rohit Joshi retweeted
Why an overreliance on AI-driven modelling is bad for science nature.com/articles/d4158…
Rohit Joshi retweeted
Your biological age is malleable but the number you get can depend on the technology. Some DNAme clocks can be off by 15 years! New corrections (using PCA) bring noise to 0.46 a 1.1 year. The take away is that clocks need to be built to suppress technical noise to be useful
Rohit Joshi retweeted
More on collective behavior: Our new Annual Review of Biophysics piece - with the stellar Danielle Chase - explores how animals sense, share information, and make group decisions. In honeybees and beyond 🐝 annualreviews.org/content/journa…
Rohit Joshi retweeted
Formins are engines powering cellular acrobatics. They are Rho family GTPases that orchestrate cytoskeleton rearrangements. They can nucleate the polymerization of actin filaments, accelerate the elongation of actin filaments, and stabilize microtubules.
Rohit Joshi retweeted
A group of physicists has proposed that space has memory, and the weight of information stored in space makes up dark matter. In today's video I have a look at the paper. youtube.com/watch?v=kTMRo-…
Rohit Joshi retweeted
A paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @DrAnneCarpenter @shantanuXsingh nature.com/articles/s4159…
Rohit Joshi retweeted
Have $10M and want to cure some diseases? It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments. Contact me - be a hero for desperate patients! docs.google.com/document/d/1dM…
Rohit Joshi retweeted
💥Check out our latest work in @NatureComms We identify a new target to impair DNA repair🧬inducing #senescence and #celldeath through synthetic lethality in combination with cancer therapy🧵 🔗Open access PDF: rdcu.be/euQkW
Rohit Joshi retweeted
Cell size varies by many orders of magnitude. The mechanisms that generate and maintain this extraordinary diversity of sizes remain incompletely understood.
Rohit Joshi retweeted
1/ No, you do not always need single-cell RNA-seq. Here's why bulk RNA-seq might still be the smarter move for your experiment.
Rohit Joshi retweeted
Key numbers in cell biology Having a sense of scale helps to think more rigorously and realistically about biological systems.
Rohit Joshi retweeted
DNA methylation protects cancer cells against senescence nature.com/articles/s4146…
Rohit Joshi retweeted
Spatial multi-omics reveals cell-type-specific nuclear compartments | Nature nature.com/articles/s4158…
Rohit Joshi retweeted
@NatMachIntell @mattersOfLight @ChanZuckerberg Read the paper, led by Ziwen Liu & @edyoshikun, here ⤵️ czi.co/44ejLd8
Rohit Joshi retweeted
Online Now! Hallmarks of stem cell aging dlvr.it/TLXcsM #stemcells
Rohit Joshi retweeted
There’s tons out there about fibroblast #mechanobiology in disease. In @ConfinementLab’s new review in @aplbioeng, Yeji gives you the who/what/where/when/how/why of mechanosensitive fibroblast activation, from CAFs to FAFs and nearly everything in between! pubs.aip.org/aip/apb/articl…
Rohit Joshi retweeted
YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates | Nature Cell Biology nature.com/articles/s4155…
Rohit Joshi retweeted
If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments. biorxiv.org/content/10.110…
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