Rini Shah @_RiniShah
Postdoc @ElphegeNoraLab at UCSF studying genome folding San Francisco, CA Joined December 2019-
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🧵How does the genome find its place in the 3D space of the nucleus after fertilization? Out now @CellCellPress: cell.com/cell/fulltext/… 👇 A thread 👇
CTCF stall DNA 🧬 loop ➰ extrusion by cohesin - but exactly how it pulls this off is a 'mechanistic mystery' (to cite @Anders_S_Hansen , Nucleus, 2020). We just preprinted 📜 a new study @biorxivpreprint that provides some answers to this enigma: tinyurl.com/3r2a4ux2
Why are some chromosomes like #21 in Down syndrome more error-prone in mammalian eggs? 🤔 Our new study in @NatureComms reveals why acrocentric chromosomes often mis-segregate, causing aneuploidy and miscarriages. (1/9) nature.com/articles/s4146…
Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)
Each month an #egg is ovulated from the #ovary, starting the journey of reproduction. But how does ovulation occur?🥚 Our latest work in @NatureCellBio led by @LastChrisThomas and @Tabea_Marx, describes the control of #ovulation using live imaging. bit.ly/3Ya8dEL (1/7)
Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.110…
First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.110… (1)
Beyond thrilled to present our first (!) work @TheCrick! A tour de force by @tobyandrews et al combining imaging, solid morphometrics, theory, perturbations to show how a developing heart grows and scales up its morphological complexity to keep beating... biorxiv.org/content/10.110…
Beyond thrilled to present our first (!) work @TheCrick! A tour de force by @tobyandrews et al combining imaging, solid morphometrics, theory, perturbations to show how a developing heart grows and scales up its morphological complexity to keep beating... biorxiv.org/content/10.110… https://t.co/Jtuvc7mci6
(1/16) Check out our @SimonMJGaudin paper tiny.cc/icuazz from the Canzio lab out in @ScienceMagazine today on how tuning local cohesin trajectories enables differential readout of the clustered Protocadherin (Pcdh) locus across different types of neurons.
'The Mechanics of building functional organs - our take on this fundamental problem. We discuss general design rules building complex 3D geometries, advocate for a holistic understanding of morphogenesis by embracing the complexity of embryonic development.cshperspectives.cshlp.org/content/early/…
'The Mechanics of building functional organs - our take on this fundamental problem. We discuss general design rules building complex 3D geometries, advocate for a holistic understanding of morphogenesis by embracing the complexity of embryonic development.cshperspectives.cshlp.org/content/early/…
📢'The World Is Your Oyster' is for those who are born in global north countries--don't experience visa bureaucracy & emotional burden that non-white global south scholars do. Citizenship is a privilege that we need to recognize in the academe. 1/n nature.com/articles/d4158…
Elated indeed to see our work getting featured on the @GenesDev cover! Want to acknowledge all the sci-art exposure in @METorresPadilla lab and in our @ChromDesign PhD network! Special mention to @carla_molins and @francesc_ribot for always motivating and inspiring!!
Elated indeed to see our work getting featured on the @GenesDev cover! Want to acknowledge all the sci-art exposure in @METorresPadilla lab and in our @ChromDesign PhD network! Special mention to @carla_molins and @francesc_ribot for always motivating and inspiring!!
It took Sergey Ulyanov and I a while to shape fountains, a novel type of chromatin architecture. Here is our story of pioneering factors binding (@onichtchouk) and the loop extrusion (@leonidmirny) working together. (can you tell that I’ve been into fishkeeping since I was six?)
Our work describing Chromatin Expansion Microscopy is now out in @ScienceMagazine science.org/doi/10.1126/sc… Check out how we were able to visualize transcription, chromatin, and TFs with molecular resolution in developing zebrafish embryos to understand gene regulation!
(1/11) Check out our paper tinyurl.com/25wvf2v2 now out in @ScienceMagazine on the role of cohesin-mediated loop extrusion in clustered Protocadherin expression and how that influences neural wiring patterns.
Today's news about transit funding is a step closer to avoiding the fiscal cliff. There is still work to do and more to learn about what this means for Bay Area transit agencies, but we are moving in the right direction.
Today's news about transit funding is a step closer to avoiding the fiscal cliff. There is still work to do and more to learn about what this means for Bay Area transit agencies, but we are moving in the right direction.
Super excited to introduce seminar series along with @DeepaSubramany4 and with immense support from @IndiaBioscience. This series will be conceptually different as speakers will not only discuss exciting science but more importantly unheard stories behind these discoveries!!
Opportunity to apply for a PhD fellowship to study gene dosage regulation on the X chromosome @CbiToulouse with @rafaelgalupa. Deadline: 8th June. More information here: jobrxiv.org/job/cnrs-centr…
Ever wondered how transient transcription factor DNA binding can robustly activate transcription? In this new preprint, we find support for one of the possible mechanisms: transcription factors exchange. A 🧵 1/9. biorxiv.org/content/10.110…
Stressed plants emit airborne sounds that can be detected from over a meter away. Lilach Hadany @YovelBatLab @TelAvivUni Learn more in @CellCellPress: cell.com/cell/fulltext/…
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