Dr BRAHMA PRASAD SADANGI @dr_brad1
Joined April 2020-
Tweets77
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Followers38
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Following262
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Likes140
š« NSCLC: Can less be more? Do we always need full-dose, lifelong TKIs? Emerging evidence says maybe not. šÆ āØ Trial insights: š Afatinib ā LUX-Lung 3/6: 30 mg ā 40 mg PFS š§ Lorlatinib ā CROWN (ALK+): early dose ā didnāt affect PFS š Alectinib ā J-ALEX (300 mg BID) vsā¦
Not just coffee - even pembrolizumab works better before 11 AM āš š Eur J Cancer 2025 | 9-center retrospective | n=450 1L Pembrolizumab monotherapy in advanced NSCLC Timing groups: š Early ā¤11:00 AM š Late >11:00 AM Results (PSM, n=206 | median f/u 62.5 mo): ā¢OS: 43.7ā¦
š¤ Do we always need chemo in mCRC maintenance? š§© š Pooled IPD ā PanaMa + Valentino (n=607, phase II) š„ Population ā¢ RAS WT mCRC ā¢ 80% left-sided ā¢ 64% ānegative hyperselectedā (no BRAF V600E, HER2, PIK3CA, PTEN, etc.) š Treatment Induction: FOLFOX + Panitumumabā¦
āØ Cure. Preserve. Personalise. ESMO 2025 ā Localised Rectal Cancer š§µš š Essentials š§² MRI for staging | š§¬ MSI/MMR testing | š„ MDT baseline š Stage I Local excision / TME š Stage IIāIII š cT2 N+ / cT3 ā CRT/SCRT (Stockholm III) š High-risk (T4, EMVI+, mrMRF+, N2,ā¦
šÆ PARP inhibitors (olaparib, talazoparib, rucaparib, niraparib) harness synthetic lethality in BRCA/HRD tumors, showing survival benefit across ovarian, breast, pancreatic & prostate cancers. š @CACancerJournal DOI š 10.3322/caac.21870 #CĆ”nCare #PARP #BRCA #HRD
šŗ Beyond 5 years: Who really benefits from extended endocrine therapy? š ESMO Open 2025 review ā¢ HR+ early BC = relapse risk persists 20 yrs after dx ā¢ Extending ET ā recurrence, esp. node+ / high-risk pts š§Ŗ Key trials š¹ ATLAS / aTTom ā Tam 10y > 5y (DFS & OS ā, butā¦
Diffuse midline glioma harboring an H3 K27M mutation who have experienced disease progression following prior therapies Dordaviprone = first FDA-approved systemic therapy specifically targeting H3 K27M mutation Recommended dose of dordaviprone is 625 mg orally once weekly
šÆ Targeted. š Immune. š¬ Precise. The new face of early NSCLC ā ESMO 2025 ā” š Key updates š§¬ Biomarker testing (EGFR, ALK, PD-L1) now mandatory in stage IBāIII š Adjuvant targeted therapy ADAURA ā Osimertinib (EGFR) ALINA ā Alectinib (ALK) š Peri-op immunotherapyā¦
Early and locally advanced non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-upā annalsofoncology.org/article/S0923-ā¦
For nowā¦ cross trial comparison is all we have! This will come over and over in our clinics for Her2+ non-small cell lung cancer. Sequencing and AE discussions so that our pts can make informed/shared decision (@jillfeldman4 šš½šš½) ! #Zongertinib #TDxD #lcsm #OncTwitter
For nowā¦ cross trial comparison is all we have! This will come over and over in our clinics for Her2+ non-small cell lung cancer. Sequencing and AE discussions so that our pts can make informed/shared decision (@jillfeldman4 šš½šš½) ! #Zongertinib #TDxD #lcsm #OncTwitter https://t.co/kG8iHyMyVC
š Management of locally advanced rectal cancer @myESMO ā Excellent summary of key trials ā Treatment recommendations based on trial evidence š šcancertreatmentreviews.com/article/S0305-ā¦ #cancer #oncology #MedX #rectal @OncoAlert @realbowtiedoc
šØ Trials to Watch ā WCLC 2025 šØ š Plenary LBAs: FLAURA2: Osimertinib + Chemo (OS update) Aumolertinib + Chemo (EGFRm NSCLC) HARMONi-A: Ivonescimab + Chemo vs Chemo ARROS-1: Zidesamtinib (ROS1+) CheckMate 816: Neoadjuvant Nivolumab (OS) EA5181: Durvalumab + CRT in Stage IIIā¦
š Testicular cancer is the most common solid tumor in people with testicles aged 15ā44. A @TheLancet seminar reviews management of seminoma and non-seminoma, follow-up, relapse strategies, and future directions. DOI šš» doi.org/10.1016/S0140-ā¦ #CĆ”nCare #oncologyā¦
ą¤µą¤æą¤ą¤¾ą¤ą¤Ø ą¤µą¤æą¤ą„ą¤·ą¤æą¤ą¤¾ ą¤øą„ą¤®ą„ą¤¤ą¤æ ą¤¦ą¤æą¤µą¤ø !!! ą¤µą¤°ą„ą¤· 1947 ą¤®ą„ą¤ ą¤°ą¤¾ą¤ą¤Øą„ą¤¤ą¤æą¤ ą¤øą„ą¤µą¤¾ą¤°ą„ą¤„ ą¤ą„ ą¤²ą¤æą¤ ą¤ą¤¾ą¤°ą¤¤ ą¤ą„ ą¤ą¤æą¤ø ą¤¤ą¤°ą¤¹ ą¤§ą¤°ą„ą¤® ą¤ą„ ą¤Øą¤¾ą¤® ą¤Ŗą¤° ą¤¬ą¤¾ą¤ą¤ą¤¾ ą¤ą¤Æą¤¾, ą¤ą¤øą¤Øą„ ą¤¦ą„ą¤¶ą¤µą¤¾ą¤øą¤æą¤Æą„ą¤ ą¤ą„ ą¤ ą¤ą¤¤ą¤° ą¤ą¤¤ą„ą¤® ą¤ą„ ą¤ą¤¼ą¤ą¤ą„ą¤° ą¤ą¤° ą¤°ą¤ ą¤¦ą¤æą¤Æą¤¾ ą¤„ą¤¾ą„¤ ą¤¦ą„ą¤¶ ą¤ą„ ą¤¬ą¤ą¤ą¤µą¤¾ą¤°ą„ ą¤ą„ ą¤¦ą¤°ą„ą¤¦ ą¤ą„ ą¤ą¤ą„ ą¤ą„ą¤²ą¤¾ą¤Æą¤¾ ą¤Øą¤¹ą„ą¤ ą¤ą¤¾ ą¤øą¤ą¤¤ą¤¾ą„¤ #VibhajanVibhishikaSmritiDiwas
š Updated treatment recommendations for systemic treatment: from the ESMO Metastatic Breast Cancer Living GuidelineāØ āļøāš„ esmo.org/guidelines/livā¦ š annalsofoncology.org/article/S0923-ā¦ @OncoAlert #OncoAlertAF #MetastaticBreastCancer
FDA Accelerated Approval Zongertinib (Hernexeos) for adults with HER2 (ERBB2) TKD-mutant unresectable/metastatic non-sq #NSCLC after prior therapy š« ā ORR: 75% (no prior HER2-ADC) | 44% (post HER2-ADC) š Daily oral TKI | Companion Dx: Oncomine Dx Target Test ā ļø Watch forā¦
A mind-opener review on muscle-invasive bladder cancer. Must-read for GU oncologist. #BladderCancer #Oncology #Immunotherapy @MattGalsky @l_ballas @UroDocAsh @ASCO @JCO_ASCO @WorldBladderCan @OncoAlert @OncBrothers @Uromigos @urologysummit doi.org/10.1200/JCO-25ā¦
No OS benefit from oxaliplatin in stage IIāIII #CRC patients >70 years! In stage III CRC, only those ā¤70 years had improved 5-year OS with oxaliplatin (85% vs 78.9%). Elderly patients discontinued chemo more often (AOR=1.55) ā linked to worse outcomes. š In stage II: noā¦
Interpretation of Pulmonary Function Tests
Do gBRCA PVs impact CDK4/6i efficacy in HR+/HER2ā MBC? This M-A in @TheBreastOnline included 16,884 pts (618 BRCA) and showed worse PFS & OS with CDK4/6i in BRCA: ā”ļø HR for PFS: up to 2.0 ā”ļø HR for OS: up to 1.7 Resistance pathways: RB1 loss, ESR1, non-luminal BC. @OncoAlert
Dr B.S.Bhati BSB š®... @BSBaiims
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Enrique Grande @drenriquegrande
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C. Michael Gibson MD @CMichaelGibson
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137 Followers 926 Following I wish my hands carve so good. My eyes colordinate them so well..That with every blink I have a smile of fostering something unknown.
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LifeLine Medical Devi... @llmd_india
757 Followers 4K Following Trusted by professionals in healthcare since 1986. We manufacture & market premium medical devices in India. Brands - Life-LineĀ® MAXĀ®
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16 Followers 85 Following
SUDHIR R. SENAPATI @SnptSudhir
164 Followers 621 Following Paediatrician by profession (ą¬ąą¬ ą¬”ą¬¾ą¬ąą¬¤ą¬°),Social Activist,Proud Indianš®š³
Dr. Darshil Rajgor @Darshil_Rajgor
2K Followers 5K Following MBBS, MS, MCh (Plastic & Reconstructive Surgery)
dr_giantes @iam_DrRahul
197 Followers 909 Following | DOCTOR | Health and Family Welfare, Govt of Odisha ą¤Ŗą„ą¤Øą¤°ą„ą¤µą¤æą¤¤ą„ą¤¤ą¤ ą¤Ŗą„ą¤Øą¤°ą„ą¤®ą¤æą¤¤ą„ą¤°ą¤ ą¤Ŗą„ą¤Øą¤°ą„ą¤ą¤¾ą¤°ą„ą¤Æą¤¾ ą¤Ŗą„ą¤Øą¤°ą„ą¤®ą¤¹ą„ą„¤ ą¤ą¤¤ą¤¤ą„ą¤øą¤°ą„ą¤µą¤ ą¤Ŗą„ą¤Øą¤°ą„ą¤²ą¤ą„ą¤Æą¤ ą¤Ø ą¤¶ą¤°ą„ą¤°ą¤ ą¤Ŗą„ą¤Øą¤ ą¤Ŗą„ą¤Øą¤ą„¤ą„¤ā
ramchand hansda @HansdaRamchand
95 Followers 348 Following If u need me I'm here If u don't need me Still I'm here
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Dr sourajit dutta @sourajit_dutta
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suman mishra @SUMANMISHRA123
240 Followers 460 Following
Dibyadarshan @DibyaDarshan12
44 Followers 299 Following Medico with a passion for tech and football āļøšā½ | Embracing the intersection of medicine and innovation | Catching the game whenever I can! š„š±ā½ #MedTechš©ŗ
DrRAJAT KUMAR PATRA @RAJATKU19456507
22 Followers 60 Following Just smile ! live n let live ā¤ļø #Medico
Er. Satya Sundar @sundar_er
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Nirmalya Kumar Giri @NirmalyaKumarG2
50 Followers 153 Following
Dr Rishabh Jain @DrRishabhOnco
675 Followers 449 Following š©ŗ DM Medical Oncologist, AIIMS Delhi š Letās keep oncology interesting !
Dr. Jason Efstathiou @drjefstathiou
1K Followers 527 Following Prof. of Radiation Oncology @harvardmed Vice-Chair, Faculty & Academic Affairs, & Director, Genitourinary Division, Dept. of Radiation Oncology @MGHCancerCenter
Mona Arbab, MD MEd @MonaArbabMD
2K Followers 2K Following Radiation oncologist, APD & assistant professor @utsw_radonc :) Alumna of @iuradonc, @brighamsurgery, Tehran University of Medical Sciences.
Parisa Shams @P_Shams_
924 Followers 1K Following ā¢ļøRadOnc PGY5 @AHNtoday| Editorial assistant @eContourRadOnc| RTOG Intern @NRGonc @RTOGFoundation|RePRT @IJROBP|Ex-Researcher @DukeRAILabs š Future @DukeRadOnc
Amishi Bajaj, MD @AmishiBajajMD
1K Followers 720 Following Radiation oncologist @OSFHealthCare and student @KelloggSchool š @DulyHealth_Care. I love my patients and lifelong learning.
Rituraj Upadhyay, MD @aiims2738
831 Followers 917 Following Assistant Prof #radonc @MoffittNews; Alumni @OSUWexMed @MDAndersonNews; @AIIMS_NewDelhi Class of ā09; #CNS #pedsoncology
Jagat Prakash Nadda @JPNadda
3.9M Followers 551 Following National President - Bharatiya Janata Party @BJP4India | Union Minister of Health and Family Welfare | Union Minister of Chemicals and Fertilizers
Sandra Turner @sandraturner49
6K Followers 6K Following radiation oncologist | med ed enthusiast | Co-Chair World Radiotherapy Awareness Day | leadership education | #radonc #WorldRTDay #WRAD #OneVoiceforRadiotherapy
Pierre Blanchard, MD @PBlanchardMD
5K Followers 287 Following Full Prof Radiation Oncology @gustaveroussy @UnivParisSaclay. EiC https://t.co/EihrJjVxi0. Director @SciencesCancer. Adjunct Prof @MDAndersonNews.
American Association ... @aapmHQ
13K Followers 6K Following Official Twitter account for the American Association of Physicists in Medicine (AAPM).
OncoDaily @oncodaily
8K Followers 7K Following Your daily dose of hope, inspiration, and information in the fight against cancer.
James Bates @JamesBatesMD
2K Followers 627 Following Asst Prof RadOnc @WinshipAtEmory #hncsm #lymsm @UF RadOnc | @UofR MD | @sunygeneseo BS Minimizing long-term effects of cancer. Tweets=mine
Kenneth Olivier @KenOlivierMD
3K Followers 956 Following Mayo Clinic RadOnc Education Chair. ADROP believer. Lung CA, SABR, and Oligomets doc. Opinions are my own and not the views of my employer.
Hossein Borghaei, DO @HosseinBorghaei
5K Followers 804 Following Chief of Thoracic Medical Oncology and Director of Lung Cancer Risk Assessment at Fox Chase Cancer Center
Constantinos Zamboglo... @CZamboglou
608 Followers 519 Following Father of 3 | Medical Director @goc_cy | Research group leader @Uniklinik_Fr | GU RadOnc | my views
Oscar Tahuahua @OscarTahuahua
1K Followers 701 Following Medical Oncologist @INCanMX | Thorac. fellow | IM | #Immunotherapy & molecular target-believer | #OncoAlertAF | Op my own
Benjamin Besse @BenjaminBesseMD
8K Followers 92 Following Medical Oncologist- Lung cancer, thymic & NUT carcinomas. Head of Clinical Research @GustaveRoussy, Head of Scientific Chairs Council @EORTC. Tweets are my own.
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32 Followers 148 Following
Mustafa ĆzdoÄan, MD @ozdogan_md
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ONCO BRUNO @brunolarvol
7K Followers 6K Following @LARVOL | 100 experts building onco super intelligence | 200,000 KM curves digitized | free for non-commercial use | ex-IBM
Dr Amol Akhade @SuyogCancer
8K Followers 138 Following Oncology care , to give or not to give chemo , data analysis , oncology pharamocovigilance , enthusiastic critic, twitts are not twists
EGFR Resisters @EGFRResisters
6K Followers 3K Following A group of EGFR+ lung cancer patients who are resistant to targeted treatment. Sharing support & research news, accelerating research, improving outcomes. #lcsm
Jason Sheehan @jasonpsheehan
884 Followers 5 Following
Fred R. Hirsch @fred_hirsch
4K Followers 59 Following I am Executive Director at the Center for Thoracic Oncology at Mount Sinai Hospital , NYC and Professor of Medicine at Icahn Medical School at Mount Sinai, NY
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1.7M Followers 3 Following We are an independent media company bringing you unparalleled coverage of all-things geo-politics & BRICS News in real-time.
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24K Followers 1K Following Small bite learningāļø, easy to read during a short breakāļø, make it simpleš, for all busy residents and fellowsš©ŗ #IDMedEd @TakaMatsuo_ID šŗšø
Dr B Borooah Cancer I... @BorooahDr
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AIIMS, New Delhi š®... @aiims_newdelhi
111K Followers 14 Following Official handle of AIIMS New Delhi for health updates, medical breakthroughs, and expert guidance. ą¤¶ą¤°ą„ą¤°ą¤®ą¤¾ą¤¦ą„ą¤Æą¤ ą¤ą¤²ą„ ą¤§ą¤°ą„ą¤®ą¤øą¤¾ą¤§ą¤Øą¤®ą„
Mirrors of Medicine @mirrorsmed
2K Followers 931 Following Open, multidisciplinary platform facilitating access to unique #CME programmes w/ focus on improving clinical decision making. Both online & offline.
Dana-Farberās Breas... @DFCI_BreastOnc
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3K Followers 955 Following Structural Interventional Cardiologist #TAVR #Mitraclip #LAA closure #PERT #PFO #CHIP #radialfirst #MGHHeartHealth trained
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16K Followers 784 Following discovery chemistry nerd @Merckgroup; oncology, immunology, targeted protein degradation, ADCs; soccer, politics, tapas can slip into the feed; my own views
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565 Followers 921 Following Clinical/Rad Oncologist l Cancer Researcher l Affiliated Asst Prof @Cambridge_Uni l Member of @CRUKCamRadNet I Audit Lead @EofERTN l Asst Editor @ClinOncology
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