James Marcus @jamespmarcus
👧🏻 dad. Trying to make sense of it all. Nurse. Ottawa, Ontario Joined March 2023-
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@DeryaTR_ Just ran two very complex cases that perplexed physicians in our 89,000-member physician Facebook group by 5Pro GPT5-pro provided an incredibly astute assessment, and extremely detailed diagnostic plan including pitfalls and limitations of prior imaging studies. There has never…
Type 2 diabetes affects hundreds of millions globally. Our research explores a suite of ML models that show the potential of using wearable data & routine blood tests to effectively predict insulin resistance, a major precursor to type 2 diabetes. More: goo.gle/4oDX9MS
A uniform truth that will play true: in three to five years, we will look back at the infrastructure we're building today and say "how stupid were we". HL7v2, CDA, FHIR...whatever we think is "the" solution will be superseded. And we'll certainly do that about FHIR. Each…
Excited to share two advances that bring us closer to real-world impact in healthcare AI: SDBench introduces a new benchmark that transforms 304 NEJM cases into interactive diagnostic simulations. AI must ask questions, order tests, and weigh costs, mirroring the complexity of…
📢 AI-enabled drug discovery reaches clinical milestone rdcu.be/eugUu Few AI-designed drug candidates have gone beyond in silico benchmarks. Now, a study in @NatureMedicine @biogerontology reports a successful phase 2a trial of rentosertib, an AI-discovered drug and…
The CMS Health Tech RFI received 1,300+ comments! While we wait for them all to be posted, I built an AI tool to analyze the first ~500. Here is the live, interactive dashboard of what it found: joshuamandel.com/regulations.go… The open-source tool deconstructs each comment into its…
1. "We are past the event horizon; the takeoff has started. Humanity is close to building digital superintelligence, and at least so far it’s much less weird than it seems like it should be." Sam Altman has once again published an article on his personal blog. It is nothing less…
Creatine and Diabetes: An Untapped Tool for Better Metabolic Health? Emerging research suggests combining creatine with resistance training can boost: 🎯 Blood sugar control ⚡ Insulin sensitivity 💪 Overall metabolic health Here’s what you need to know 🧵1/8
That's a death rate of 14.8% in the control group vs 9.2% in the exercise group, a 37% reduction. If this was a drug, it would be considered an extraordinary breakthrough.
This is just the beginning of the movement towards A.I. powered keyboard liberation for clinicians gift link wsj.com/health/healthc…
We raised $6.5 million to build the world's most powerful creative tool.
Why AI will be central to new Carleton University nursing school ottawacitizen.com/news/local-new…
"My Data, My Code, My Health" Welcome back to Fun with the CMS/ASTP/ONC RFI! Today's Policy: Establish a TEFCA Patient-Developer Credential Full Rec: joshuamandel.com/cms-rfi-collab… Voice: Lupus Patient, Open Source Enthusiast & Homelab Hobbyist --- Managing Lupus effectively means…
Random thought: The value of my time is deflationary The longer I delay working on my app, the more productive each hour gets (as the models and tooling get better) If I wait 3 months we probably have Sonnet 4.0 and Gemini 3.5 or whatever So maybe the rational move is to take…
this piece honestly means so much to me
this piece honestly means so much to me https://t.co/nsO5bjslgY
Harvard and University of Toronto researchers dropped an AI for 3D medical image & video segmentation Built atop Segment Anything Model 2.1, MedSAM2 generalizes across organs, modalities, and pathologies with an 85%+ reduction in annotation costs
How can we build AI models that retain general knowledge while acquiring deep, domain-specific understanding - and even generate new ideas grounded in science? We find that, surprisingly, merging two specialized models can create a new model with capabilities neither one had…
Better as X article: x.com/tobi/status/19…

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