Jinwei Zhang Lab @jinweizhang
RNA structural biology lab at NIH; believes #RNA lives and interacts in 3D space. All views my own. www-mslmb.niddk.nih.gov/zhang/zhanglab… Bethesda, MD Joined June 2009-
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Jinwei Zhang Lab retweeted
excited to join this panel for a free webinar on the journal editor career path hosted by Life Science Editors, coming up on October 7. scan the QR code in the image or visit lifescienceeditors.com to learn more and register!
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Jinwei Zhang Lab retweeted
New online! tRNA as an assembly chaperone for a macromolecular transcription-processing complex bit.ly/42cF5Qb
Jinwei Zhang Lab retweeted
Great start to the 3rd day of @MeetingRna with RNA Binding Proteins session! Invited talks from @woodson_lab on Hfq-driven kinetic selection of sRNA targets and @KatieBerryRNA on bacterial KH-domain proteins set the stage for a series of exciting selected talks. #RNA2025
Jinwei Zhang Lab retweeted
Congratulations to @AlexBoRNA who presented the 2025 Colworth Medal Lecture today! Alex discussed how his work positions viral replication organelles as tractable systems for dissecting the biophysical principles underpinning RNA selection and turnover #BiochemAwards
Jinwei Zhang Lab retweeted
Our September issue is live! nature.com/nchembio/volum… The cover image depicts translocation of synthetic condensates and DNA and RNA, facilitated by engineered DNA- and RNA-binding proteins, from the cytoplasm to the nucleus in the presence of small molecules.
Jinwei Zhang Lab retweeted
Collaboration with M.G.Finn’s group at @GeorgiaTech ! We present protein nanocrates—icosahedral cages that protect samples from the air–water interface, a major source of artifacts in cryo-EM. A widely applicable solution to preferred orientation! biorxiv.org/content/10.110…
Jinwei Zhang Lab retweeted
Want to know how lipidation of some nascent chains takes place by NMT2-- Check our latest work on how NAC couples Protein Synthesis with Nascent Polypeptide Myristoylation on the Ribosome out today @embojournal : embopress.org/doi/full/10.10…
Jinwei Zhang Lab retweeted
My lab's very first manuscripts are out!!! - We identified nearly 60 conserved #RNA structures in plastids - We found that transcriptional response to warm temperatures in whole seedling is confounded by response at organ level #thermomorphogenesis Link to both preprints below
Jinwei Zhang Lab retweeted
A comprehensive statistical analysis of how Q-scores are related to reported resolution, based on ∼10 000 EMDB maps and associated PDB atomic coordinate models archived in the EMDB @UCSanDiego @ActaCrystD @IUCr #CryoEM #QScores #Validation doi.org/10.1107/S20597…
Jinwei Zhang Lab retweeted
Perhaps our boldest hypothesis… we propose a model for RNA Structural Memory propagation @NatureCellBio, where RNA conformation is reshaped by stress, locked by RBPs, copied prion-like in condensates & passed across generations—all without altering DNA.🧵 rdcu.be/eBwPJ
Jinwei Zhang Lab retweeted
We are pleased to share our paper "Structures and mechanisms of U6 snRNA m6A modification by METTL16” Nature Communications doi.org/10.1038/s41467…
Jinwei Zhang Lab retweeted
Disulfide-based dimerization of modified nanobody scaffolds enables higher-order assembly for high-resolution cryo-EM structure determination that is widely applicable to small protein targets nature.com/articles/s4158…
Jinwei Zhang Lab retweeted
New online! Integrated structural biology of the native malarial translation machinery and its inhibition by an antimalarial drug bit.ly/4mluP07
Jinwei Zhang Lab retweeted
Featured on the cover of @ScienceMagazine, BioEmu @MSFTResearch, a deep learning system that rapidly generates diverse protein conformations for accurate insights into protein function. Illustration: N. Burgess/Science; Data: S. Lewis et al., science.org/toc/science/38….
Jinwei Zhang Lab retweeted
#Guanidine was known since the 1870s to affect muscle function. Vertebrates have guanidine-sensing #riboswitch RNAs linked to genes relevant to muscle disorders, including some for Ca2+ signaling and others relevant to #ataxia symptoms. @NatureComms nature.com/articles/s4146…
Jinwei Zhang Lab retweeted
Excited to share our latest work with the bullock lab! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. biorxiv.org/content/10.110…
Jinwei Zhang Lab retweeted
New group leader opportunity @JohnInnesCentre - We're looking for interests in (not limited to) growth and development, environmental/organismal interactions, physiology, signalling, cell biology, biochemical, and modelling approaches jic.ac.uk/vacancies/grou…
Jinwei Zhang Lab retweeted
GAGA zinc finger transcription factor searches chromatin by 1D–3D facilitated diffusion nature.com/articles/s4159…
Jinwei Zhang Lab retweeted
New online! Structural insights into higher-order natural RNA-only multimers bit.ly/4m6opSt
Jinwei Zhang Lab retweeted
New preprint alert! We developed a covalent small molecule that targets guanines in structured RNAs, guided by the FMN riboswitch structure. In collaboration with Rob Batey biorxiv.org/content/10.110… #RNA #DrugDiscovery #ChemicalBiology
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46 Followers 32 Following
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112 Followers 268 Following https://t.co/x2ZfCMFek7 | K99/R00 fellow in John Carlson's Lab, Yale. Driven by all the mysteries in RNA biology.
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