Interesting case of AL-amyloidosis. Massive vascular deposits, even in hilar arterioles with glomerular sparring. Patient had minimal proteinuria given lack of glomerular amyloid. #renalpath#pathtwitter#nephrology
Do you know how the proximal tubule brush border is related to the Nobel Prize in Chemistry? Normal proximal tubules have a prominent apical brush border which is highlighted by periodic acid Schiff (PAS) staining. One clue, in fact, to the presence of tubular injury is the loss…
🚨New in #ADPKD: Biomarkers for disease progression, neatly mapped into Genetic, Clinical, Imaging & Molecular domains
A must-see framework for researchers & clinicians working on risk stratification & precision nephrology🫘
🔗 doi.org/10.1016/j.ekir…#Nephrology#MedTwitter
ANSWER: A
A recent study published by Sethi et al. demonstrated the presence of two proteins, Exostosin1 (EXT1) and Exostosin 2 (EXT2), along the GBM of PLA2R-negative MN. In this study, the authors showed that 81% of the EXT1/EXT2-associated MN showed features of autoimmune…
ANSWER: A
A recent study published by Sethi et al. demonstrated the presence of two proteins, Exostosin1 (EXT1) and Exostosin 2 (EXT2), along the GBM of PLA2R-negative MN. In this study, the authors showed that 81% of the EXT1/EXT2-associated MN showed features of autoimmune…
#USCAP2025 w/ Dr Mete
Differentiated neuroendocrine neoplasms have lineage specificity- they replicate some of the developmental biomarkers based on their anatomic region or location. Contrast to NECs which ❌ respect lineage specificity (aberrant expression)
#PathWebinarPearls
The Bethesda system for thyroid cytology helps classify cytopuncture (fine needle aspiration) results and guide diagnosis. Here are 10 key scenarios in category III (AUS/FLUS) that require careful interpretation for proper follow-up.
#USCAP2025 w/ Dr Voltaggio
Identifying 4 lines helps avoid missed dysplasia in upper GI & reduces equivocal cases → fewer interventions. Loss of lines = dysplasia.
4 Lines:
1.mucin cap
2.bottom of mucin cap
3.cytoplasm
4.nuclei
#PathWebinarPearls
#TeachingPoints The patient is a 75 year-old female who presents with proteinuria, a necrotic skin lesion on her lower extremity, and a creatinine of 5.5 mg/dL. Her serum complement levels (C3/C4) are low. Serologies for ANA, dsDNA, rheumatoid factor, c-ANCA, p-ANCA, anti-GBM,…
#TeachingPoints A 75 year old woman presented for her annual checkup with no complaints. She had a past medical history of hypertension and her blood pressure at this visit was 160/80. Laboratory findings were significant for an elevated serum creatinine at 2.1 mg/dL (baseline…
This glomerulus is large! Glomerular enlargement, or glomerulomegaly, may be diagnosed when a glomerulus sectioned though the hilum fills greater than 50% of a 40x microscopic field. It is thought to be a morphologic marker of glomerular hyperfiltration. While not specific,…
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