second scight empowers biotech and pharma companies with comprehensive data consulting services to accelerate drug developmentsecondscight.com Strasbourg, FranceJoined April 2024
Mechanotransduction in the nucleus
Multiple TFs transmit mechanical forces into transcriptional regulation.
Nuclear shape, size, and chromatin abnormalities are common features of many diseases.
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THREAD 🧵
Regular exercise reduces the likelihood of plaque accumulation in the arteries
However, many long-term exercisers appear to have coronary artery calcification, indicating atherosclerosis progression
The fascinating thing is that despite the higher plaque, those people still…
🇨🇳5 Things BeiGene Can Teach Us About the Future of China-Driven Biotech
If you want to understand where biotech R&D is going, don’t just look to Boston.
Look to BeiGene.
They’ve quietly built one of the most ambitious, vertically integrated R&D engines anywhere in the world.…
Proud to share our new @Nature study: We developed the 1st NNMT inhibitor that reprograms cancer-associated fibroblasts, boosting immune response & stopping tumor growth in ovarian cancer models, especially when paired with immunotherapy. @OvCa_UChicagonature.com/articles/s4158…
Another $2B COPD opportunity just hit a brick wall.
Yesterday, the Roche / Amgen IL-33 Astegolimab missed its primary endpoint in the Ph3 ARNASA study - the second failure of an IL-33 in a few months, after the Regeneron / Sanofi AERIFY-2 study of Itepekimab failed in May…
MOPPIT: De Novo GENERATION OF MOTIF-SPECIFIC PEPTIDE BINDERS VIA CONDITIONAL UNIFORM DISCRETE DIFFUSION
Researchers have introduced moPPIt, a novel algorithm for the de novo generation of motif-specific peptide binders. This method is particularly significant as it can design…
🗨️ “Vaccines have done more to improve public health than any other medical intervention.”
A new Viewpoint focuses on cancer vaccines and the future of immunotherapy—analysing trials, different vaccine approaches, and how the next generation of cancer vaccines can help improve…
BREAKING: MIT just completed the first brain scan study of ChatGPT users & the results are terrifying.
Turns out, AI isn't making us more productive. It's making us cognitively bankrupt.
Here's what 4 months of data revealed:
(hint: we've been measuring productivity all wrong)
Absolutely insane amount of data in this resource from @mason_lab
The Spatial Atlas of Human Anatomy (SAHA): A Multimodal Subcellular-Resolution Reference Across Human Organs
biorxiv.org/content/10.110…
Spatial data on 15million cells from 100 donors across multiple ages, mainly GI
China has now surpassed all other countries in number of new oncology clinical trials launched each year, AND also number of novel active substances (NAS) for cancers launched. @IQVIA_globaliqvia.com/library/videos…
Another reason a P3 study can fail while a P2 was successful is that P2 placebo groups, with narrower eligibility criteria & fewer patients, often have more variable placebo-adjusted effects
Use Phase 3 data, often on drug labels, to make comparisons; They're more consistent
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