Umar Farooq, PhD @umarbioc
Senior scientist at Jinfeng Laboratory investigating glioblastoma research #immunology #therapeutic. https://t.co/KqjUxtagDA Winnipeg, Canada Joined July 2014-
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A novel method for generating human CAR-NK cells by the use of multiple cytokines and anti-CD2 and anti-NKp46 stimulatory antibodies 🇯🇵 sciencedirect.com/science/articl…
PD-1 Bispecific Killer Engager effectively depletes effector T lymphocytes in experimental autoimmune encephalomyelitis @FrontiersIn frontiersin.org/journals/immun…
Online Now: Glioblastoma hijacks cholinergic networks dlvr.it/TMmFCX
Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results @NatureMedicine 🇨🇳 nature.com/articles/s4159…
MYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition dlvr.it/TMgtCJ
Online Now: A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision dlvr.it/TMgxVZ
AAV-Mediated CAR-T therapy eradicate HIV-infected CD4 T cells in human cell culture and humanized mice @biorxivpreprint biorxiv.org/content/10.110…
A new blog from OpenAI and Retro Bio describes a custom AI model (“GPT-4b micro”) that can design better Yamanaka factors, the proteins used to reprogram mature cells into induced pluripotent stem cells. In 2006, a scientist named Shinya Yamanaka discovered four proteins that…
A facile chemical strategy to synthesize precise AAV-protein conjugates for targeted gene delivery dlvr.it/TMfgwR
Effects of CRISPR-Cas9-mediated FOXP3 knockout on CAR T-cell potency dlvr.it/TMd04j #MTMCD
Mitochondria are known as the "powerhouses" of a cell. But that is a ridiculously incomplete description. A new study shows that human cells "weaponize" mitochondria during infection. Mitochondria ramp up their metabolism to deprive pathogens of folate, a molecule required for…
For the first time, the FDA has approved a drug, ONC201, for diffuse midline gliomas. Carl Koschmann (@CarlKoschmann) answers questions about the U-M research that led to the approval and what it means for patients. Link: michmed.org/WXd3Z
The #AACRBlog examines promising clinical applications of AI, including its ability to enhance cancer diagnosis and guide precision medicine. Learn more: brnw.ch/21wV5xl #AACRai25
Systematic decoding of functional enhancer connectomes and risk variants in human glioma nature.com/articles/s4155… #journals #feedly
Congrats BruceTrapnell @CincyResearch on the phase 3 trial of inhaled molgramostim (human GM-CSF) in autoimmune pulmonary alveolar proteinosis nejm.org/doi/full/10.10… nejm.org/doi/full/10.10… @NEJM
Online Now: Long-range cholinergic input promotes glioblastoma progression dlvr.it/TMZVrT
Brain editing now ‘closer to reality’: the gene-altering tools tackling deadly disorders @Nature nature.com/articles/d4158…
Inhibition of TMEM16F-mediated lipid scrambling provokes robust antitumor immunity by enhancing ferroptosis @ScienceAdvances science.org/doi/10.1126/sc…
New #JITC review: Genetic drivers of tumor microenvironment and immunotherapy resistance in non-small cell lung cancer: the role of KEAP1, SMARCA4, and PTEN mutations bit.ly/3Hzc6yO
Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications dlvr.it/TMWGK8

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