📰 Novel Therapies in Systemic Sclerosis (SSc): 2025 Breakthroughs
Based on Ike et al., Best Pract Res Clin Rheumatol, 2025
DOI: 10.1016/j.berh.2025.102104
1️⃣ SSc Essentials
•Autoimmune fibrosis + vasculopathy
•Women 4:1; ↑ severity in Black/Indigenous pts
•Subtypes:
•…
✨ IgG4-Related Disease: Emerging Insights
One of the best #IgG4RD articles I’ve come across! Published in Allergy (2025) 🧾
🔹 4 Clinical Phenotypes
Pancreato-biliary | Retroperitoneal/Aortitis | Head & Neck | Mikulicz/Systemic
🔹 Key Biomarkers
Plasmablasts, galectin-3, CCL18…
🩸 Evans syndrome = rare, relapsing, life-threatening.
High infections, thrombosis, mortality.
Until now → scattered case reports, case series and observation studies, no RCTs.
👉 Not “just ITP + AIHA.”
It needs:
• Structured diagnosis
• Tailored immunosuppression
•…
🔬 Nailfold videocapillaroscopy (NVC) helps flag active #SLE
✅ SLE showed more NVC abnormalities (203 SLE vs 178 healthy controls)
🧷 Most SLE had a normal pattern (86.6%); scleroderma patterns in 9.5%
🧩 Two patterns:
• Cluster 1: milder features
• Cluster 2 (~12%): lower…
So how much steroid do colleagues give in SARD-ILD? Duration? Starting dose? Do you keep them on maintenance? Why? assuming that you will also commence the patient on DMARD/bDMARD Monotherapy initially if they are not progressive..🫁 #Rheumatology#MedTwitter#ILD@RheumNow
Las redes sociales nos han vendido una mentira: que las relaciones felices son las que viajan mucho, comen en sitios caros y tienen fotos perfectas. Spoiler: no es verdad. Las relaciones de verdad se sostienen en lo cotidiano. En lo aburrido. En lo que no se sube a Instagram.
No sé quién necesite leer esto pero, no necesitas esa salina para mantener una vena permeable.
La vena ya está permeable we.
Usa la vía oral mientras puedas mamón
La vida sigue, te quieran o no.
La vida sigue, estén a tu lado o no.
La vida sigue, te apoyen o no.
La vida sigue, te correspondan o no.
La vida sigue, te salgan bien las cosas o no.
La vida sigue, ojalá nunca lo olvides. tienes que seguir… pero esta vez por ti.
Los que dicen que la obesidad no es factor de riesgo aumentado para cáncer, no saben nada de inmuno. Ni de endocrino. Ni de gine. Ni de fisiopatología.
IL-17is demonstrate efficacy in SpA tx
Comparable with TNFis & JAKis in terms of achieving ASAS40 response rates
IL-17is are generally well-tolerated w/⬇️TB risk (very important tx consideration esp in Asia)
But watch out for candidal infx, IBD exacerbation
@RheumNow#APLAR25
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