The ASCO Post @ASCOPost
News and views from the world of clinical oncology and hematology ASCOPOST.COM Huntington, NY Joined December 2009-
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New research finds intratumoral microbial signatures in GI cancers correlate with metastatic risk and response to treatment 🦠 Granulicella linked to higher metastasis risk 🦠 Dorea associated with protective immune response ascopost.com/news/september… #CancerResearch
Phase III CONKO-007 study: Chemoradiotherapy didn’t significantly raise overall R0 resection rates vs chemo alone in pts with unresectable pancreatic cancer (25% vs 18%) @JCO_ASCO Patients undergoing surgery saw OS benefits. ascopost.com/news/september… #pancreaticcancer
Insights from Lisa R. Diller, MD, of @DanaFarber, on accelerated aging in survivors of childhood cancers: 🔸20% of general population develops ≥1 serious condition by age 65 vs 55% among cancer survivors 🔗 ascopost.com/news/september… #Survivorship #ChildhoodCancer
Multianalyte test shows ability to detect CNS cancers from just a bit of CSF 🧠81% sensitivity; 100% specificity Corresponding author: @BettegowdaMDPHD @HopkinsMedicine #NeuroOncology #BrainCancers ascopost.com/news/august-20…
The #FDA has approved BTK inhibitor rilzabrutinib for adult patients with persistent/chronic #ITP who had insufficient response to a prior treatment. 🔸Supporting data: durable platelet response at week 25 (23% vs 0% with placebo) in LUNA 3 ascopost.com/news/september… #FDAApproval
Real-world study of monoclonal antibodies: 6.7% had ≥1 infusion-related reaction (mostly grade 1/2) @jcoop. 🔸 Rituximab: 26% incidence 🔸 Nivo+ipi: 13% incidence By Elise J. Smolders, PhD, PharmD, et al @IsalaZiekenhuis 🔗 ascopost.com/news/august-20… #Oncology #sideeffects
ImmunoTACE: Improved PFS with dendritic cell–based vaccine + TACE + cyclophosphamide vs TACE + cyclophosphamide alone for intermediate-stage #HCC ⏲️ Time to progression: 18.6 vs 10.4 mo Chief Investigator: David Adams, MD, FRCP @unibirmingham ascopost.com/news/august-20…
Lutetium Lu-177 dotatate active in progressive PPGLs, especially in patients with sporadic disease 🔸Median PFS: 19.9 mo overall, 24.3 mo with sporadic disease 🔸Median OS: 51.7 mo overall, not reached with sporadic disease #Neuroendocrine @theNCI ascopost.com/news/august-20…
Children’s Oncology Group @COGorg ALTE03N1 Analysis: Childhood cancer survivors with germline mutations had significantly greater risk for subsequent neoplasms. Mutations added to a clinical risk classifier model for more accurate risk prediction ascopost.com/news/august-20…
Cervical cancer incidence and mortality are 67% and 108% higher in low-resource US counties with low screening rates❗️ Repeat low coverage counties mostly found in Texas, Idaho, New Mexico @ResearchMUSC #CervicalCancer ascopost.com/news/august-20…
A new study challenges the long-standing maximum tolerated dose model. Report by @DrDonaldHarvey, Laura Levit, etc highlights impacts of former approach @ASCO and @US_FDA collaboration proposes 5 principles for safer, more effective cancer drug dosing ascopost.com/issues/august-…
From @Muhamma69621474: how AI is reshaping patient interaction and advice for physicians on how to adapt to this new era 👉 Provides insights from resource-constrained settings ascopost.com/news/august-20… #AIinMedicine #GlobalOncology
The #NIH’s new 15% cap on F&A costs could spell the end of US cancer research Currently supports 60K+ grants and 300K+ researchers From @AACI_Cancer’s Jennifer Pegher, MA, MBA; Emily Stimmel, MA; Robert Winn, MD @VCUMassey ascopost.com/issues/august-… #OpEd #CancerResearch
Routine symptom screening significantly reduced self-reported symptom burden in newly diagnosed pediatric patients with cancer by weeks 4 and 8. Lower overall symptom burden reported @adamyan677 🔗 ascopost.com/news/august-20…
🌟 Tips for fellows and trainees: what @JasmineKambojMD, @Noha_Soror, and @chadinabhan wish they had known during hematology-oncology #fellowship ascopost.com/news/august-20…
Phase III KEYNOTE-585 final analysis: perioperative pembrolizumab + chemo showed a median OS of 71.8 mo vs 55.7 mo with chemo alone for gastric/GEJ cancers (HR = 0.86) No new safety signals; similar grade ≥3 AE rates @KoheiShitara ascopost.com/news/august-20… #GI #Immunotherapy
Breast cancer weight-loss intervention may help determine if weight loss can reduce recurrence risk Participants lost an average 4.7% of body weight From Jennifer Ligibel, MD, et al @DanaFarber ascopost.com/news/august-20… #lifestylemedicine #cancerresearch #bcsm
Adding everolimus to carboplatin in advanced #TNBC reduced the risk of disease progression or death by 52% vs carboplatin alone By Amy Tiersten, MD, @RimapatelMD @IcahnMountSinai ascopost.com/news/august-20… #BCSM #HCC #Immunotherapy
A new study finds unmet social needs are linked to notably lower trust in cancer information from doctors, health-care system, etc. 📉 Up to 61% drop in trust with a lack of housing, food, and/or transport @BaekerBispo ascopost.com/news/august-20… #psyonc #SDOH #healthequity
Combination of tafasitamab and lenalidomide reduced risk of disease progression/relapse/death by 57% in R/R follicular lymphoma 🔹PFS = 22.4 vs 13.9 mo 🔹 Safety profiles remained manageable ✍️ @MarekTrnenyDr ascopost.com/issues/august-…

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ASCO @ASCO
149K Followers 2K Following Account of the American Society of Clinical Oncology & its affiliate the Association for Clinical Oncology. Assoc tweets labeled #ASCOAdvocacy. RTs ≠ endorse.
Oncology Brothers @OncBrothers
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