Copper Deficiency Anemia! Rare but seen in: TPN Postbariatric surgery Celiac dz Excessive zinc intake Menkes disease Anemia+neutropenia (thrombocytopenia rare) Variable MCV Mimic of MDS as dysplasia can be seen in marrow Cytoplasmic vacuolization erythroid/myeloid precursors
@AaronGoodman33 Zinc oxide-based denture creams used to do it as they interfered with copper absorption Anemia without an obvious cause with neuropathy and I'll check it just in case
@AaronGoodman33 Probably my most cited paper… pubmed.ncbi.nlm.nih.gov/18284630/
@AaronGoodman33 + subacute combined degeneration of the spinal cord
@AaronGoodman33 @Innov_Medicine Copper deficiency anemia is characterized by low levels of copper in body, leading to decreased red blood cell production.
@AaronGoodman33 Apparently CRRT too. karger.com/nef/article/14…
@AaronGoodman33 Made this diagnosis in a TPN patient once. Ordered copper a lot for the next 15 years! 😂
@AaronGoodman33 DDx: Anemia and cytoplasmic vacuoles und bone marrow —> consider VEXAS-Syndrome, escpecially in men with an unknown inflammatory syndrome
@AaronGoodman33 Saw this a few times when it was popular to take lots of zinc during the pandemic.