Andrea Pasquadibisceglie @andpdb.bsky.social @AndPdb
Staff Scientist @Tigem_Telethon linkedin.com/in/andrea-pasq… Pozzuoli, Campania Joined April 2017-
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Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
Un 38enne recupera la vista grazie a una terapia genica: primo caso al mondo a Napoli #terapiagenica #29luglio #napoli #tigem #telethon tgcom24.mediaset.it/salute/terapia…
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Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
New Online! Molecular machineries shaping the mitochondrial inner membrane bit.ly/4jW82XD
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
A huge milestone for personalised #mRNA therapeutics for inherited disease! A baby with an ultra-rare mitochondrial disease was treated at UPenn with an mRNA-encoded gene-corrector. The mRNA was made to treat a single individual in just 7 months! nejm.org/doi/full/10.10…
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR seqs is finally out. We run an antibody LM in parallel & added its logits to ProteinMPNN's, fixing most issues we encountered. It also increased % of HER2-binding trastuzumab designs >10-fold
Our several-years-old fix to ProteinMPNN's tendency to make weird antibody CDR seqs is finally out. We run an antibody LM in parallel & added its logits to ProteinMPNN's, fixing most issues we encountered. It also increased % of HER2-binding trastuzumab designs >10-fold https://t.co/6GbROv0oRe
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
📢Ritorna la Walk of Life di Torino! La ricerca corre, corri anche tu: 🏃♀️🏃♂️il 25 maggio ti aspettiamo alla III edizione della Walk of Life di Torino, un’occasione di incontro per dare una speranza concreta a chi affronta una malattia genetica rara. bit.ly/4j5MW7U
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
The follow-up work by @TrizioEnrico and @PeilinKang is out on @NatComputSci!🧨 A semi-automatic method to extensively sample "everywhere and everything" (metastable and transition states) "all at once" (in a single simulation) 🔥 📑: nature.com/articles/s4358… Short🧵 @IITalk
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
Protein modeling may be swiftly pivoting from one-shot prediction to steerable, context-aware generation. Example: FKSFold uses Feynman-Kac control to inject ipTM rewards into AlphaFold3’s diffusion and rescues 3 of 8 tough molecular-glue ternaries.
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
A Perspective by Stephanie Wankowicz and James Fraser discusses ways macromolecules use conformational entropy to control binding, catalysis, and allostery nature.com/articles/s4158…
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
We are recruiting a colleague to our division at Chalmers in Data-Driven Life Science (broadly defined), a competitive starting package is offered and you get to be part of a support, yet young and ambitious research environment.
Great collaboration with Pontus Gourdon's lab! Through coulmn-masking of the MSA, we were able to use AlphaFold3 to model different end-states of a membrane transporter in complex with its cargo.
Great collaboration with Pontus Gourdon's lab! Through coulmn-masking of the MSA, we were able to use AlphaFold3 to model different end-states of a membrane transporter in complex with its cargo.
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
So proud to see our work on machine learning + enzyme design just published! doi.org/10.1016/j.cels… Fun collaboration between @Theteamatx @GoogleDeepMind & @triplebarbio that we hope can be a template for integrating ML and high throughput screening in protein engineering
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
GNINA 1.3: the next increment in molecular docking with deep learning 1/ GNINA 1.3 is the latest version of the open-source molecular docking software, introducing deep learning enhancements for more efficient and accurate structure-based drug design. 2/ This update replaces…
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
#compchem Happy to see this one out in @NatureComms: "Histidine 73 methylation coordinates beta-actin plasticity in response to key environmental factors". nature.com/articles/s4146… We used large scale molecular dynamics simulations coupling adaptive sampling and the AMOEBA…
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
🚀 PhD Opportunity – NC-mTORC1 & Genetic Diseases! Join @Tigem_Telethon & Univ. of Naples to explore Non-Canonical mTORC1 signaling in mTORopathies like BHD & TSC!
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
Rapid and accurate prediction of protein homo-oligomer symmetry using Seq2Symm @NatureComms 1/ This study presents Seq2Symm, a deep learning model fine-tuned from ESM2 for predicting the symmetry of homo-oligomeric protein assemblies, outperforming template-based and prior deep…
Andrea Pasquadibisceglie @andpdb.bsky.social retweeted
Structural biology is in an era of dynamics & assemblies but turning raw experimental data into atomic models at scale remains challenging. @mhli41 and I present ROCKET🚀: an AlphaFold augmentation that integrates crystallographic and cryoEM/ET data with room for more! 1/14.
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Tigem Telethon @Tigem_Telethon
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Physics In History @PhysInHistory
958K Followers 0 Following Photos from the history of physics | © with mentioned Archives. Shared for educational purposes. Einstein portrait © Ullsteinbild. Subscribe for curated papers.
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