I am a mathematician working as a Senior Scientist in the Department of Biosystems Science and Engineering, ETH Zurich.sites.google.com/site/drankitgu… Basel, SwitzerlandJoined May 2020
To preserve their internal states, living systems often need to fully adapt to disturbances from their environment. Researchers from the @KhammashLab characterise the universal structures for maximally robust biomolecular networks
> bit.ly/3DWPsuJ@PNASNews@ETH_en
Credit to my amazing co-author @AnkitGuptaMath and to @ERC_Research for funding.
Thanks also to @ETH_en and @ETH_BSSE for providing an excellent research environment and for their continued support.
We apply our results to several known biological examples of robustly adapting networks.
We also show how our linear algebraic characterization can be exploited for the design of adapting genetic controllers.
How do biological networks maintain tight regulation of variables while being subjected to an onslaught of perturbations?
We establish simple universal principles for maximal robust adaptation in all biomolecular systems.
pnas.org/doi/10.1073/pn…#sysbio#synbio#cybergenetics
Ever needed to grow microbial communities w. different growth rates at fixed population ratios?
Here we combine light-controlled antibiotic resistance w/ automated composition sensing & cybergenetics to achieve precise ratiometric control of co-cultures.
doi.org/10.1038/s41467…
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Tucumano
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Stochastic modelling of gene expression and intracellular biochemical dynamics.
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