Brain @Brain1878

Brain: A Journal of Neurology. Publishing leading studies in neurological science since 1878. academic.oup.com/brain London Joined January 2014

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Brain @Brain1878

45 minutes ago

Using lesion network mapping in military Veterans with a history of head trauma, Siddiqi et al. identify a distinct pattern of brain damage associated with increased intensity of political involvement across both liberals and conservatives. tinyurl.com/3sdpy7yy

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Brain @Brain1878

12 hours ago

Chelban et al. screened more than 650 individuals with multiple system atrophy and found FGF14 GAA•TTC repeat expansions in about 3% of cases. The expansions were associated with more rapid mobility loss and shorter survival. tinyurl.com/3v3fj554

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Brain @Brain1878

a day ago

Bringing fragile X-associated neuropsychiatric disorders into the phenotypic fold of premutation conditions New scientific commentary by Randi Hagerman tinyurl.com/j6tup6fx

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Brain @Brain1878

a day ago

Küçükali & Hill et al. integrate GWAS data with transcriptome and proteome-wide association studies to better understand risk factors for sporadic Creutzfeldt-Jakob disease, the most common human prion disease. tinyurl.com/4rcms55u

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Brain @Brain1878

2 days ago

Hu et al. compare the cognitive and psychiatric features of atypical parkinsonian syndromes – such as MSA, progressive supranuclear palsy, and corticobasal syndrome – to help improve diagnostic accuracy. tinyurl.com/3ypthwb5

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Brain @Brain1878

2 days ago

T cells turn in Alzheimer’s disease New scientific commentary by Donal Skelly et al. tinyurl.com/bdr6cxd3

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Brain @Brain1878

2 days ago

September's issue of Brain is now online! academic.oup.com/brain/issue/14…

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Brain @Brain1878

3 days ago

Abdelhak et al. show that blood levels of neurofilament light chain reflect potentially reversible demyelination-induced nerve fibre injury in animal models of demyelination as well as in people with multiple sclerosis. tinyurl.com/h2b4kbs4; tinyurl.com/yre4xsm7

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Brain @Brain1878

3 days ago

Using biopsies and a mouse model, Meli et al. show reduced dopaminergic innervation and altered patterns of dopamine receptor expression in focal cortical dysplasia type 2. tinyurl.com/mstznh5d

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Brain @Brain1878

4 days ago

Immune myopathies can be resistant to immunosuppressive treatment. Hou et al. show that interferon-gamma impairs muscle regeneration, and that the JAK1/2 inhibitor ruxolitinib can counteract this effect. tinyurl.com/mrzmewvp; tinyurl.com/33hwhd8f

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Brain @Brain1878

4 days ago

Malaichamy et al. identify a rare heterozygous missense variant in ATP2A2 in individuals with recurrent rhabdomyolysis. The variant alters SERCA2 function, leading to abnormal intracellular calcium homoeostasis in skeletal muscle. tinyurl.com/52te5yb2

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Brain @Brain1878

6 days ago

Valentino et al. present the results of a GWAS of neuropathological outcomes in almost 1500 Lewy body disease cases. APOE ε4 was associated with more severe LBD pathology in cases with low levels of AD pathology, whereas APOE ε2/ε3 was protective. tinyurl.com/2c2af99t

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Brain @Brain1878

a week ago

Huang et al. investigate the longitudinal relationship between MRI markers of cerebral small vessel disease and cognitive function, and find that cortical cerebral microinfarcts and brain atrophy interact synergistically to accelerate cognitive decline. tinyurl.com/2s46y3u6

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Brain @Brain1878

a week ago

Wang et al. describe the clinical, radiological, pathological, and prognostic features of general paresis and identify characteristics that can help distinguish it from other dementias. tinyurl.com/wmn399tz

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Brain @Brain1878

a week ago

Abreaction was once a common treatment for functional neurological disorder (FND) but has since fallen out of use. Norman Poole argues that abreaction is compatible with many findings from modern neuroscience, and should be tested as a treatment for FND. tinyurl.com/fcjpywx2

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Brain @Brain1878

a week ago

Teoh et al. assess corticosteroid treatment in autoimmune neurological disease in the light of available preclinical and clinical evidence, highlighting gaps in the literature that should be considered when designing future therapeutic approaches. tinyurl.com/4s7fccef

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Brain @Brain1878

a week ago

Arizanovska et al. report that prolonged D-serine release from activated glia following brain injury triggers reactivation of developmental synaptic pruning. Targeting this pathway could help protect patients with TBI from cognitive decline. tinyurl.com/554j27s7

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Brain @Brain1878

a week ago

Mitchell et al. highlight normative modelling as a new approach to TBI. By comparing patients to reference cohorts, this method could overcome limitations of traditional classification systems, enabling personalised treatment and improved clinical trials. tinyurl.com/4yp5b58a

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Brain @Brain1878

a week ago

Espay et al. challenge the view that AD results from increased gamma-secretase activity and Aβ42 overproduction. Instead, they suggest that reduced Aβ42 levels drive disease - and that restoring these above a compensation threshold could slow progression. tinyurl.com/2ymnaxhs

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Brain @Brain1878

a week ago

Guo et al. engineered liver cells to release vesicles carrying SOD1-targeting siRNA. These reached the spinal cord and eased symptoms in an ALS mouse model, suggesting potential as a future treatment strategy for SOD1-linked ALS. tinyurl.com/mrycdat2