CRIC @CRIC_Int_Care
Collaboration for Research in Intensive Care (CRIC), Denmark #IntensiveCareTrial #HOTICU #AIDICU #SUPICU #CLASSIC #GODIF #COVID_STEROID_2 cric.nu Joined October 2017-
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The conclusion of #HOT_COVID_trial was In adult ICU patients with COVID-19 and severe hypoxemia, targeting a Pao2 of 60 mm Hg (8 kPa) resulted in more days alive without life support in 90 days than targeting a Pao2 of 90 mm Hg (12 kPa) Not that we hope to see COVID pts in ICU
The conclusion of #HOT_COVID_trial was In adult ICU patients with COVID-19 and severe hypoxemia, targeting a Pao2 of 60 mm Hg (8 kPa) resulted in more days alive without life support in 90 days than targeting a Pao2 of 90 mm Hg (12 kPa) Not that we hope to see COVID pts in ICU
The effect of the primary outcome was supported by sensitivity analyses and those of secondary outcomes
The effect of the primary outcome was supported by sensitivity analyses and those of secondary outcomes https://t.co/OMj4tEihIy
Primary outcome - days alive wo life-support at 90 days - was 80.0 days in the lower O2-target group vs. 72.0 days in the higher group (P = .009; bootstrapped adjusted mean difference, 5.8 days [95% CI, 0.2-11.5 days]) There were no meaningful sub-group differences in effect
Primary outcome - days alive wo life-support at 90 days - was 80.0 days in the lower O2-target group vs. 72.0 days in the higher group (P = .009; bootstrapped adjusted mean difference, 5.8 days [95% CI, 0.2-11.5 days]) There were no meaningful sub-group differences in effect https://t.co/CT4Kzd6y8W
The protocol, i.e., lower vs higher oxygenation targets while in ICU, separated the 2 allocation groups
The protocol, i.e., lower vs higher oxygenation targets while in ICU, separated the 2 allocation groups https://t.co/5Kcne7y44c
Of the 726 pts randomised most patients were analysed 69% were males Age 65 years 24% on invasive ventilation 13% on non-invasive Most with P/F-ratios < 100 Randomisation occured 3 hours after ICU admission
Of the 726 pts randomised most patients were analysed 69% were males Age 65 years 24% on invasive ventilation 13% on non-invasive Most with P/F-ratios < 100 Randomisation occured 3 hours after ICU admission https://t.co/46VJrGlMu7
#HOT_ICU_trial was swiftly transformed to #HOT_COVID_trial planned to enrol 780 pts The trial was terminated early after the winter 22-23 and the omicron variant because of very few pts in ICUs with severe hypoxemia At that time 726 patients had been enrolled
#HOT_ICU_trial was swiftly transformed to #HOT_COVID_trial planned to enrol 780 pts The trial was terminated early after the winter 22-23 and the omicron variant because of very few pts in ICUs with severe hypoxemia At that time 726 patients had been enrolled https://t.co/nMdAcLBNeY
It started out by the observation in the #HOT_ICU_trial that the 100 pts enroled with #COVID_19 had benefits from the lower vs. higher oxygenation target (published as a post-hoc analysis onlinelibrary.wiley.com/doi/epdf/10.11…
It started out by the observation in the #HOT_ICU_trial that the 100 pts enroled with #COVID_19 had benefits from the lower vs. higher oxygenation target (published as a post-hoc analysis onlinelibrary.wiley.com/doi/epdf/10.11…
Massiv effort from alot of good people 🙏 @AalborgUH @BodilSRasmussen @TLKlitgaard @OlavSchj @UCPH_health @TheisLange7024 @Rigshospitalet @Majkja @AndersPerner Staff, patients & relatives in 11 ICUs in 🇩🇰🇳🇴🇨🇭 Funded by @UFM_MIN Handled well by @seymoc @JAMA_current
Massiv effort from alot of good people 🙏 @AalborgUH @BodilSRasmussen @TLKlitgaard @OlavSchj @UCPH_health @TheisLange7024 @Rigshospitalet @Majkja @AndersPerner Staff, patients & relatives in 11 ICUs in 🇩🇰🇳🇴🇨🇭 Funded by @UFM_MIN Handled well by @seymoc @JAMA_current
HOT of the press #HOT_COVID_trial on Lower vs Higher Oxygenation Target and Days Alive Without Life Support in ICU patients with COVID-19 and severe hypoxemia jamanetwork.com/journals/jama/…
Tomorrow, I will defend my PhD. Everyone is welcome! Should be available online by joining the team-meeting but tech-support is low🍀
The ICU at University Medical Center Groningen in the Netherlands has now been initiated and ready to include patients in the GODIF trial. Congratulations and welcome to the GODIF team 👏🏻 #GODIF #Cric_Int_Care #ICU #clinicaltrials #fluidoverload
💦 Restricting IV fluids in adults with septic shock in #ICU: analysis of CLASSIC trial. Restriction resulted in similar survival, HRQoL, cognitive function at 1 year vs standard therapy but clinically important differences could not be ruled out #FOAMcc 🖇️rdcu.be/deP7j
Welcome to the ICU in Reykjavik to the GODIF trial. We are looking forward to the collaboration @martiningi #CRIC_Int_Care #GODIF #ICU #clinicaltrials
Discussing organic delirium at Psychiatric Center Glostrup today. @CRIC_Int_Care
The second trial to be presented at #CCR23 is AID-ICU Can haloperidol improve outcomes for patients with delirium? @ARanberg presenting Join us in Titanic Belfast, June 14th to 16th, to discuss the best critical care trials in the world. criticalcarereviews.com/meetings/ccr23
Newest insights from the HOT-ICU trial
Newest insights from the HOT-ICU trial
The 4th Scandinavian Intensivist Meeting is now open for sign-up CPH 10-12 May 2023 ssai.info/event/sim2023/
Today I presented the AID-ICU trial on behalf of the AID-ICU trial team at the @ESICM. We are proud to announce that the manuscript is now available online at NEJM: nejm.org/doi/full/10.10… @CRIC_Int_Care @SUHhospital @ole_mathiesen @AndersPerner @MusaeusPoulsen
In this randomized trial, treatment with haloperidol did not increase the number of days alive and out of the hospital among ICU patients with delirium. #LIVES2022 nej.md/3VCuHMU
Lower (8 kPa) vs higher oxygenation (12 kPa) targets: no longterm survival benefit nor HRQoL improvement at 1y in #ICU pts with severe hypoxaemia (HOT-ICU trial cohort). Substantial impairments in several EQ-5D-5L dimensions in survivors in both groups. 🖇️ bit.ly/3EwbfJm
Critical Care Reviews @CritCareReviews
62K Followers 883 Following The leading critical care evidence dissemination platform. CCR25, Belfast, June 11-13. Now on the nice Blue platform too....
Anders Granholm @andersgranholm
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Segun Olusanya (He/Hi... @iceman_ex
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Giuseppe Citerio @Dr_Cit
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Fernando Zampieri @f_g_zampieri
5K Followers 724 Following Previous posts do not reflect my current opinion. Yet another critical care physician.
Johannes Grand @JohannesGrand
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Critical Care @Crit_Care
56K Followers 700 Following Critical Care is an international open access journal that publishes articles in all areas of intensive care and emergency medicine.
Dr Matt Morgan @dr_mattmorgan
13K Followers 6K Following ICU doctor & Prof of Public Engagement. Author of Critical, One Medicine & A Second Act. Advisor on NT's Nye & BBC R4 Best Medicine. Loves🍦. Rep: @ce_seymour
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Jakob Burcharth @JakobBurcharth
520 Followers 501 Following Physician-Scientist @EMERGECPH / Acute care surgeon @Herlevgentofte / Dad & family-guy / Loves running & star-gazing
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Søren Lund Kristense... @SLKristensen
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Victor Skeppstedt @Skippstripps
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Katrine Feldballe Ber... @KBernholm
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Charlotte Levy Hansen @CLevyHansen
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Luke Collett @crit_care_reg
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Chris Schenck, MD @ChrisSchenck4
274 Followers 1K Following He/him | PGY3 @MGHmedres | Proud @MGBUnited | MD @YaleMed | Interested in cardiology, critical care | Probably hanging out with my cats | FREE PALESTINE
غـيداء @_Ghaida97
762 Followers 698 Following Hematology/Oncology Pharmacy Fellow at @ksumedicalcity | PharmD | BCPS | Enjoying life 🎈 ✨
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Sepsis Australia @sepsisAU
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Beatrice Brunoni @bea_brunoni
47 Followers 174 Following Intensive Care Resident, University Milano Bicocca
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15 Followers 50 Following MD, PhD fellow | Anaesthesiology | Princical investigator on the RECIPE RCT | Dad 👧🏼, football romantic ⚽️ and heavy metal enthusiast 🤘
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526 Followers 546 Following Intensivist & Anesthesiologist. Love research and study. Interested in original questions. Most importantly, a happy father!
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46 Followers 615 Following
Kevin Seitz @kseitz
254 Followers 622 Following Tweets are my own. RTs and follows are not endorsements.
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د.عبدالله ا�... @Alkhudayri
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Jaime Thomson @nedthomson74
34 Followers 210 Following Derigible pilot and amateur nuclear physicist. I pass my days drinking and watching alien conspiracy docs on the History C. My philosophy; never tweet sober
Sabahat H Zaidi @xabahat
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Gabriele Martelli @G_Martelli_
103 Followers 342 Following Intensive care physician and anesthetist. Grateful to practice medicine every day, standing on the shoulders of giants. Proud father.
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目空世界 @mukongworld
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steffen @SteffenChr
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Fewtrella @Fewtrella1
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13 Followers 97 Following MD. PhD. Anesthesiologist. ICU @CopenhagenUniversityHospital-Hvidovre.
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Intensive Care Medici... @yourICM
75K Followers 146 Following International peer-reviewed medical journal for all involved in Intensive Care #FOAMed #FOAMcc 🖋 Write https://t.co/j4p0oZF5XA 📨 Submit https://t.co/BJMsQ4rNz3
Critical Care Reviews @CritCareReviews
62K Followers 883 Following The leading critical care evidence dissemination platform. CCR25, Belfast, June 11-13. Now on the nice Blue platform too....
ESICM @ESICM
42K Followers 281 Following European Society of Intensive Care Medicine is an association promoting education, research, and professional development in intensive care medicine.
Critical Care @Crit_Care
56K Followers 700 Following Critical Care is an international open access journal that publishes articles in all areas of intensive care and emergency medicine.
INCEPT @INCEPTdk
133 Followers 82 Following INCEPT: The Intensive Care Platform Trial research programme. Profile no longer active, updates on website: https://t.co/hesjeYJUCu
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856 Followers 684 Following Greater Copenhagen EU Office represents universities, regions and municipalities in Eastern Denmark.Trends for United States
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