Kai-Hsiang Chuang @Chuang_Lab
MRI physicist, Functional brain imaging, Biomedical engineering, Neuro Joined January 2023-
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Amazing breakthrough in understanding functional connectivity!
Amazing breakthrough in understanding functional connectivity!
1/11 Excited to share our @naturestudy led by @Leon_Oo1 @csabaorban @ZShaoshi doi.org/10.1038/s41586… It is well-known that AI performance scales with logarithm of sample size (Kaplan, McCandlish 2020), but in many domains, sample size can be # participants or # measurements...
Intra-cisternal Gd contrast MRI is a gold standard for imaging glymphatic function in vivo. But, a large Area-Under-the-Curve (AUC) is not necessary "high" glymphatic flow. It could be slow efflux, leading to more Gd retention. For detail: nature.com/articles/s4146…
Does cholinergic neurodegeneration impact glymphatic system? We lesion cholinergic neurons that project to the hippocampus. We find hippocampal, but not cortical, vascular-CSF concordance is impaired, suggesting a causal role. For detail: nature.com/articles/s4146…
We uncover cholinergic deficits in aging affect CSF dynamics using simultaneous fMRI and cholinergic PET scans in healthy elderly. For details, see nature.com/articles/s4146…
Our new findings highlight an important role of cholinergic deficits in glymphatic dysfunction in aging. australianageingagenda.com.au/research/uq-br…
Our 6-yr efforts is finally published on Nature Communications! We discover a neural pathway that regulates the glymphatic system. Its deficit in aging and dementia may result in the pathology. This suggests new targets for diagnosis and treatment. nature.com/articles/s4146…
How is the glymphatic system regulated? Why it is impaired in aging and Alzheimer’s disease? Now we have a new answer: the cholinergic neurons! nature.com/articles/s4146…
This blew me away
Revolutionary!
This is what’s bugging me about AI denoise. Vendors always show you how pretty the normal human image is improved. But the real issue is whether it will also clean up pathology??
This is what’s bugging me about AI denoise. Vendors always show you how pretty the normal human image is improved. But the real issue is whether it will also clean up pathology??
Insightful study for us working on small sample size:)
Insightful study for us working on small sample size:)
A neat design that addresses the awkward position of rodent body in MRI and results in greatly improved sensitivity of CBF imaging.
A neat design that addresses the awkward position of rodent body in MRI and results in greatly improved sensitivity of CBF imaging.
More rigorous testing like this is needed to design effective nuisance removal methods. Yet, the simulated movement didn’t include the effects of magnetic field change induced by real motion.…
More rigorous testing like this is needed to design effective nuisance removal methods. Yet, the simulated movement didn’t include the effects of magnetic field change induced by real motion.…
🔔🔵After nearly 5 years from its conception with @BohacekLab, I'm proud to share that our paper on opto-fMRI of the Locus Coeruleus is finally published in @NatureNeuro! Huge thanks to everyone who contributed—including reviewers and editors! rdcu.be/dT3kB
Just out from the press, my article for the 40 year anniversary of Diffusion MRI showing how the first years (1984-94) shaped the whole field to investigate the brain and its connectome, normal or diseased, and the body, notably for oncology. link.springer.com/article/10.100…
What regulates waste clearance of the brain? Using human & animal imaging, we identified a neural pathway that modulates BOLD-CSF coupling and glymphatic flux. Its degeneration in aging and dementia could underlie glymphatic deficits. biorxiv.org/content/10.110…
💡1 PhD and 1 Postdoc position still open for joining my new lab @unige_en and help us re-defining the use of MRI for tracking biological processes #neuromodulation #fMRI #optogenetics #CellReplacementTherapy. Contact me for more information! Pls RT 🙏
We’re recruiting a PhD student to study how our brain clear the waste (glymphatic system) and how to enhance its function to facilitate health. study.uq.edu.au/study-options/…

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