RFdiffusion2 is now live!
github.com/RosettaCommons…
You can now design proteins, and in particular enzymes from just partially defined amino acid side chains, and without defining their sequence position or order!
Great job @r_krishna3@woodyahern@dougtischer and everyone else!
After a 4-year journey, we are super happy to see this paper out in @NatureComms - @ElezKatarina et al: High-throughput molecular dynamics + active @machinelearning enable efficient identification of an experimentally-validated broad coronavirus inhibitor.
nature.com/articles/s4146…
PROTEINGPT: MULTIMODAL LLM FOR PROTEIN PROPERTY PREDICTION AND STRUCTURE UNDERSTANDING
1.ProteinGPT is a multimodal language model that allows researchers to input both protein sequences and 3D structures to ask detailed natural language questions. It integrates structure and…
AI-Guided Discovery and Optimization of Antimicrobial Peptides Through Species-Aware Language Model
1.This study introduces LLAMP, a species-aware AI model for predicting antimicrobial peptide (AMP) activity. LLAMP significantly outperforms existing models in predicting MIC…
Deep-learning-based single-domain and multidomain protein structure prediction with D-I-TASSER @NatureBiotech
1.D-I-TASSER is a hybrid deep-learning and physics-based pipeline that outperforms AlphaFold2 and AlphaFold3 in both single-domain and multidomain protein structure…
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!
These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.
Save and share the post!
Hands-On Large Language Models!
This repository contains the complete code examples from the book Hands-On Large Language Models.
It includes notebook examples that cover everything from the introduction to language models to fine-tuning them.
100% Open Source
Are you new to #CryoEM, or looking for a review of the basics?
You might enjoy our TRPV1 case study! It covers preprocessing, particle curation, refinement, and more! You can also test your skills with the advanced exercises at the end of the study. guide.cryosparc.com/processing-dat…
We are recruiting 🤩🤩🤩!!! If you are looking to establish your lab in a multidisciplinary institute with state-of-the-art facilities, horizontal structure and diverse faculty, apply!!!
My Google Scholar profile has now crossed 1000 citations. Grateful to all my mentors and collaborators. Looking forward to more research and discoveries ahead! 🔬📚
#1000Citations#Science#AcademicMilestone#Research
Improving AlphaFold2 and 3-based protein complex structure prediction with MULTICOM4 in CASP16
1. The paper presents MULTICOM4, a system integrating AlphaFold2, AlphaFold3, and in-house techniques to improve protein complex structure prediction.
2. MULTICOM4 was evaluated in…
BAnG: Bidirectional Anchored Generation for Conditional RNA Design
1/ This study introduces RNA-BAnG, a deep learning model for designing RNA sequences that interact with specific proteins without requiring extensive experimental data or RNA structural information.
2/ The core…
A Generalized Platform for Artificial Intelligence-powered Autonomous Protein Engineering
1/ This paper introduces a generalized platform for autonomous protein engineering, leveraging artificial intelligence (AI) and biofoundry automation. It eliminates the need for human…
IndiaAI Mission announced a Call for Proposals for building India's Foundation Models on January 30, 2025.
Proposals will be reviewed by the 15th of every month, until enough proposals have been selected or 6 months, whichever is earlier.
Effective Gene Expression Prediction and Optimization from Protein Sequences
1. This study introduces a novel AI-driven pipeline to predict and optimize soluble protein expression in heterologous hosts. By leveraging transfer learning and advanced protein modeling, the authors…
Thrilled to kick off the new year with our latest publication: 'Mechanistic Insights into the Divergent Membrane Activities of a Viroporin from Chikungunya Virus and Its Transframe Variant.' A deep dive into structure-function dynamics! #Viroporinpubs.acs.org/doi/10.1021/ac…
Free online course:
MLCB24 - Machine Learning in Computational Biology Fall 2024 from @manoliskellis@MITyoutube.com/playlist?list=…
L1: Course Overview, Machine Learning, Deep Learning, Generative AI, and the Unification of Biology
Module1:…
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