In AFib pts ≥80 yrs meeting dose-↓ criteria, pts randomized to edoxaban 15 vs. 30 mg had comparable rates of stroke/SE. Edox 15 mg led to a trend toward ↑ ischemic strokes but ↓ major & intracranial bleeds; supported by PK/PD analysis. @AndreZimerman@rgiugliano#ESCCongress
In frail, elderly, AF patients, a randomized analysis shows that switching from warfarin to a DOAC lowered risks of stroke, ICH, and death vs. remaining on warfarin. DOACs increased bleeding overall, but magnitude varied by choice of DOAC. @rgiuglianoclinicalkey.com/#!/content/pla…
科学者Gの回想:自らFirst and Corresponding Authorになる! youtu.be/SvmU1O3zgwA?si…@YouTubeより 科学者Gは当時注目されていなかった心房細動に注目し、自らがFirst and Corresponding Authorになることで皆の了承を得て論文を作成した。論文はJAMAにはいけず, Circulationにもいけなかった。
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