Czech Lab @CzechLab
Isadore and Fannie Foxman Professor and founding chair of @ProgMolMed at @UMassChan umassmed.edu/czechlab/ Worcester, MA, USA Joined October 2021-
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Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice. biorxiv.org/cgi/content/sh… #bioRxiv
“This tree is something we can look back at over the years with pride.” Learn about the special tree planted at UMass Chan Medical School: direc.to/jRHL @CzechLab @CorveraLab @tammytnguyen @ProgMolMed @UMassDiabetes @UMassVascSurg @BUMedicine @EmersonCollege
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program dlvr.it/SnngT4
The @CzechLab reports that DNL provides fatty acids for membrane-expanding processes like autophagy @ProgMolMed @UMassChan nature.com/articles/s4146…
The @CzechLab examined the metabolic regulation of #adipocytes by #insulin receptor signaling and the cAMP signaling pathway in a review article published in @TrendsCellBio umassmed.edu/dcoe/news/umas… #diabetes #research @UMassChan @ProgMolMed
@CzechLab and @CorveraLab Fun
Newly published #research from @CzechLab in @jbiolchem studied fat production in the liver from carbohydrates by disrupting an enzyme that helps to convert blood glucose into fat. umassmed.edu/dcoe/news/umas… #T2D @UMassChan @ProgMolMed
Our new review is out today too ! The adipocyte supersystem of insulin and cAMP signaling sciencedirect.com/science/articl…
Our new paper is out! Thank you for all the collaborators for their invaluable contribution! Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice. jbc.org/article/S0021-…
Meet Sarah & learn about her #type2diabetes #research in @CzechLab using genetic engineering to investigate a therapeutic approach by modifying adipocyte genes to increase fat burning & improve metabolic function. umassmed.edu/dcoe/news--eve… @UMassChan #researchers @NatureComms
Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice. biorxiv.org/cgi/content/sh… #bioRxiv
@Emmanouela_17 is exploring a cell therapy for #type2diabetes by manipulating the genome of fat cells to improve their metabolic function. Meet Dr. Tsagkaraki & learn more! umassmed.edu/dcoe/news--eve… #diabetes #metabolism #research @CzechLab @CorveraLab @UMassChan @ProgMolMed
@UMassDiabetes is using “good fat” to improve metabolism & potentially treat Type 2 diabetes & obesity. Published #research in @NatureComms shows implanted CRISPR-enhanced adipocytes improved glucose tolerance. @CzechLab @CorveraLab @ProgMolMed @UMassChan nature.com/articles/s4146…
Ever wondered how CRISPR can ameliorate type 2 diabetes? Excited to share our work published @NatureComms We show implanting CRISPR-enhanced adipocytes can improve glucose tolerance in mice! @CzechLab @CorveraLab @ProgMolMed @UMassDiabetes @ESontheimerLab nature.com/articles/s4146…
Check out our new publication from @CzechLab in collaboration with @KhvorovaL in @UMassChan @ProgMolMed @UMassDiabetes @UMassMedRTI on development of an #RNAi therapeutic for #NASH cell.com/molecular-ther…

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