David Cook @DavidPCook
Ovarian cancer, Single-cell genomics, Cell plasticity | Scientist, Cancer Therapeutics, @OttawaHospital | Assistant Professor, @OttawaCMM cooklab.ca Ottawa, Ontario Joined October 2013-
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David Cook retweeted
Excited to share our recent manuscript out at @Nature . @piraner and @majo__duran from @roybal_lab and @Mohamad_Abedi and @AdamChazin in David Baker's lab engineered synthetic receptors that sense natural and designer soluble cues. nature.com/articles/s4158…
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David Cook retweeted
📢Excited to share our work on @biorxivpreprint "Spatiotemporal map of the developing human reproductive tract at single-cell resolution"! Beyond grateful to our amazing team @ceci_icoresi @LuzGarAl @roserventotormo @MarioniLab and collaborators for their contributions. 🧵[1/10]
David Cook retweeted
A protein expression atlas on tissue samples and cell lines from cancer patients provides insights into tumor heterogeneity and dependencies. nature.com/articles/s4301…
David Cook retweeted
This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov
David Cook retweeted
1/🧵Excited to re-introduce Memento in (cell.com/cell/fulltext/…), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇
David Cook retweeted
Interactive design and validation of antibody panels using single-cell RNA-seq atlases biorxiv.org/content/10.110…
David Cook retweeted
snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives👏 nature.com/articles/s4200…
David Cook retweeted
Happy publication day for us! Labor of love with @CoffmanLab #TLS #ovariancancer @UPMCHillmanCC @PittTweet The activity of tertiary lymphoid structures in high grade serous ovar... sciencedirect.com/science/articl…
David Cook retweeted
🚀 Excited to share our new publication in @NatureBiotech! We explore scalable strategies for phenotypic screening using innovative methods with to address the challenges when the number of candidates is simply too large. Check out the details tinyurl.com/5f8vjhpp! (1/10)
David Cook retweeted
STAMP: Single-Cell Transcriptomics Analysis and Multimodal Profiling through Imaging | bioRxiv @DrJasPlummer @hoheyn @pascual_reguant @eliseinsing @cnag_eu @ACEpigenetics @StJudeResearch biorxiv.org/content/10.110…
David Cook retweeted
3D cellular CODA maps of the fallopian tube are used to guide the design of "assembloids" that recapitulate the complex architecture and ciliated-based motion of oocytes. See more here: science.org/doi/10.1126/sc…
David Cook retweeted
FICTURE: scalable segmentation-free analysis of submicron-resolution spatial transcriptomics | Nature Methods nature.com/articles/s4159…
David Cook retweeted
FixNCut: A Practical Guide to Sample Preservation by Reversible Fixation for Single Cell Assays bio-protocol.org/en/bpdetail?id…
David Cook retweeted
(1/n) Excited to announce a new article with @rafalab @AviSahuAI describing our approach scDist for finding cell types with transcriptional changes between conditions in single-cell data! nature.com/articles/s4146…
David Cook retweeted
Using single-cell and spatial transcriptomics data, FlowSig provides a unified signaling modeling framework by connecting intercellular communication mediated by ligand-receptor interactions and intracellular gene expression modules. nature.com/articles/s4159…
David Cook retweeted
Our new #paper is out in @NatImmunol. Applying #spatial transcriptomics at subcellular resolution to 130 ovarian #cancer tumors, followed by data-driven experimental design and high content #CRISPR screens to map immune evasion in ovarian cancer nature.com/articles/s4159… (1/15)
David Cook retweeted
Earlier this week we carried out a preliminary analysis of our first @10xGenomics Xenium prime (5,000 gene) run. We had designed this experiment to get a sense of how the prime chemistry performed compared to the Xenium V1 chemistry.
Earlier this week we carried out a preliminary analysis of our first @10xGenomics Xenium prime (5,000 gene) run. We had designed this experiment to get a sense of how the prime chemistry performed compared to the Xenium V1 chemistry.
David Cook retweeted
SeuratExtend: An Enhanced Toolkit for scRNA-seq Analysis github.com/huayc09/Seurat…
David Cook retweeted
FixNCut: A Practical Guide to Sample Preservation by Reversible Fixation for Single Cell Assays bio-protocol.org/en/bpdetail?id…
David Cook retweeted
Our opinion piece is out today, "The origin of novel traits in cancer"! Do the phenotypes come first and only later are they locked in by genetic or epigenetic changes? Insights from evolutionary biology are super useful for understanding cancer! cell.com/trends/cancer/… #S_Frank
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