Higher inflammation in midlife is linked to smaller brain volume later in life, including the memory center. Lower sugar, eat more fiber, and choose healthy fats to protect your brain. Read more here: drperlmutter.com/inflammation-t…

@DavidPerlmutter The 24-year brain shrinkage correlation is striking, but starting an anti-inflammatory protocol at 53 might already be too late. Earlier intervention windows could be more protective.

Exactly. Midlife inflammation is one of the strongest predictors of later-life cognitive decline - and it’s striking how diet sits at the centre of this. In my work with the Bredesen Protocol, we consistently see that reducing sugar, increasing fibre, and optimising omega-3 and monounsaturated fats not only lowers inflammatory markers but can stabilise or even improve cognition. Protecting brain volume isn’t just about genes or age - it’s about creating an anti-inflammatory internal environment decades before symptoms appear.