Immunity @ImmunityCP
Cutting-edge research in immunology from around the world. This account is no longer monitored, and content is automated. Join us on BlueSky! cell.com/immunity Cambridge, MA, USA Joined May 2011-
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Online now: Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4 dlvr.it/TNHvVH
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Immunity retweeted
#InterferonPower! Li, Park &co show @ImmunityCP that IL-15 negatively regulates CD103 on CD8 T cells allowing effector function & that engagement of CD103 by E-cadherin+ dendritic cells is necessary to drive CD8 T memory formation via type I IFNs & IL-12! dlvr.it/TN59Qv
Immunity retweeted
2/2 Yet, dendritic cells had another go with @AbigailRAltman, who won Best Poster Award with "Transcription factor blueprints underlying dendritic cell diversity", now out in Immunity (cell.com/immunity/fullt…). Congrats to both! It's great to have our contributions recognized!
Immunity retweeted
Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration: @ImmunityCP cell.com/immunity/fullt…
Immunity retweeted
Wu lab discovers early neuronal hyperactivity in TDP-43 induces rod-shaped microglia, which attenuates cortical hyperactivity, suggesting a neuroprotective role. Coincidentally, TREM2 signaling also promotes rod-shaped MG & neuroprotection. cell.com/immunity/abstr…
Immunity retweeted
Nucleosome phasing by chromatin remodelers regulates macrophage lineage fidelity by preserving nucleosome arrays flanking PU.1-bound sites to prevent lineage-inappropriate transcription by C/EBPβ @ImmunityCP 🇮🇹cell.com/immunity/fullt…
Immunity retweeted
Hypoxia within the tumor microenvironment drives chronic activation of ATF4, which promotes metabolic polarity and cell death of tumor-infiltrating CD8+ T cells @ImmunityCP @ThaxtonLab @UNC 🇺🇸 cell.com/immunity/fullt…
Immunity retweeted
S. aureus causes a basophil influx into skin-draining lymph nodes that heightens Th2 responses & increases serum IL-4, which enhances intestinal permeability, exaggerating oral anaphylaxis (links dermatitis to food allergy) @ImmunityCP 🇺🇸🇮🇳 @harvardmed cell.com/immunity/fullt…
Immunity retweeted
Findings by researchers @pryprk @palakmanchanda4 @DavalosLab, Gaurav Chopra, et al. show that excess fat in the brain’s resident immune cells, #Microglia, impairs their ability to combat disease. Learn More in @ImmunityCP 👉 cell.com/immunity/abstr…
Online now: Control of myeloid lineage fidelity and response to stimuli by ISWI-enforced nucleosome phasing dlvr.it/TNHpxd
Online now: S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis dlvr.it/TNHfTh
Together with our partners @sjtu1896, we’re excited to bring you a fresh perspective on the multifaceted role of the #immunesystem at @CellSymposia #CSImmuneHomeostasis26, taking place May 11–13, 2026 in Shanghai, China. Discover more: hubs.li/Q03JLXvX0
Immunity retweeted
Perspective @ImmunityCP A roadmap for defining “extrafollicular” B cell responses cell.com/immunity/fullt… 🇺🇸🇬🇧 @nbaumgarth @StephanieEisen @VinuesaLab @jason_cyster @elsner_rebecca @GarnettKelsoe @ShlomchikLab @ShivPillai4 @ToeKai
Online now: A roadmap for defining “extrafollicular” B cell responses dlvr.it/TNDH8b
Immunity retweeted
Work from the Wu lab led by Manling Xie describing the role of rod-shaped microglia in TDP-43 neurodegeneration is out now in Immunity! @McGovernMed
Work from the Wu lab led by Manling Xie describing the role of rod-shaped microglia in TDP-43 neurodegeneration is out now in Immunity! @McGovernMed
Immunity retweeted
Our study @ImmunityCP uncovered rod-shaped microglia as key responder to cortical hyperactivity in TDP43 neurodegeneration. These specialized microglia align with dendrites, remodel synapses, and provide protection via TREM2 signaling. Thanks @Manling_Xie for the leading efforts!
Our study @ImmunityCP uncovered rod-shaped microglia as key responder to cortical hyperactivity in TDP43 neurodegeneration. These specialized microglia align with dendrites, remodel synapses, and provide protection via TREM2 signaling. Thanks @Manling_Xie for the leading efforts! https://t.co/JufQYCKJLk
Online now: Rod-shaped microglia interact with neuronal dendrites to attenuate cortical excitability during TDP-43-related neurodegeneration dlvr.it/TN9h9w
Last chance! #CSCancerImmunity2025 early registration discount closes tomorrow (Sept 19) Hear keynotes from Ira Mellman (@parkerici) & Carl June (@Penn) + experts on T cells, tumor microenvironments & synthetic immunity. hubs.li/Q03JKvdJ0 #Oncology #Immunotherapy
Lindsay Hall (@hall_lab, @unibirmingham) joins @CellSymposia #CSMicrobiome2026 to explore early-life microbiota development, May 10–12, Bruges. Abstracts due Jan 16. hubs.li/Q03JKsXt0
Online now: A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer dlvr.it/TN5L7w
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