JCellBiol @JCellBiol
The Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Est. 1955 - @RockUPress jcb.org New York, NY Joined September 2009-
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UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope, say Yongrong Liao @YongrongL Izabela Sumara @SumaraLab and colleagues @IGBMC: hubs.la/Q02tNRYK0 #CellCycle #Organelles
Image: structural conservation rather than sequence motifs determines effects of minor satellite (MinSat) RNAs on chromosome segregation. From Yung-Li Chen, Andreas Ettinger, @METorresPadilla et al. @HelmholtzMunich: hubs.la/Q02t10k80 #centromeres #StemCells #CellDivision
Unveiling the TRAPP: The role of plant TRAPPII in adaptive growth decisions. Antonio Galindo @MRC_LMB highlights study from Assaad, Wiese, and colleagues (hubs.la/Q02tNFNt0) in Spotlight: hubs.la/Q02tNzkR0 #PlantBiology #Trafficking
BRG1 programs PRC2-complex repression and controls #oligodendrocyte differentiation and remyelination, say Jiajia Wang, Qing Richard Lu and colleagues @CincyChildrens: hubs.la/Q02tPny-0 #Development #Neuroscience #Chromatin #epigenetics
Great to share new insights into diarrhea disease models with JCB readers! @VanderbiltCDB @EBCVanderbilt
Great to share new insights into diarrhea disease models with JCB readers! @VanderbiltCDB @EBCVanderbilt
Video shows cross-kingdom structural alignment of the TRAPPII-specific TRS120 subunit. From Wiese, Assaad et al. @TU_Muenchen suggesting that shaggy-like kinases mediate plant adaptation to environmental cues by phosphorylating TRAPPII. hubs.la/Q02rkS970 #PlantBiology
Calcium ions promote #migrasome formation via Synaptotagmin-1, say Yiyang Han and Li Yu @Tsinghua_Uni: hubs.la/Q02tCxmn0 #migration #motility #membrane #lipid
New Review: @iKajiLab, @JRTlab and @GoldenringLab @VUMChealth discuss recent findings in cell, organoid, and animal models for monogenic diseases causing congenital diarrhea and enteropathies (CODEs). hubs.la/Q02vmpq30 #Disease #Physiology #Trafficking
Scott, Roux et al. @SanfordResearch show that changes in the availability of cellular GTP resulting from physiologically relevant processes, including cell migration and cell spreading, alter the rates of Ran-dependent nuclear import and export. hubs.la/Q02vl-6l0
Krakowczyk et al. (hubs.la/Q02sSV0g0) identified the OMA1 protease as a critical component that eliminates import failure at the TOM translocase in mammalian cells. Shiori Sekine & Yusuke Sekine @AgingPitt discuss the findings: hubs.la/Q02sSQ7d0 #mitochondria
New news! Our latest (preprintless) story on MVB maturation taking place on a subset of septin-coated microtubules. Ben Robinson's PhD thesis and the last opus from my 15-year Drexel residency. A tweetorial to follow.
New news! Our latest (preprintless) story on MVB maturation taking place on a subset of septin-coated microtubules. Ben Robinson's PhD thesis and the last opus from my 15-year Drexel residency. A tweetorial to follow.
Going steady for maturity: a subset of CD63-rich #endosomes partner with #microtubule-associated #septins, which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New from @SeptinLab @drexel_coas @UVa_CellBio: hubs.la/Q02v9FQ30
Viewpoint: Campanella and Kannan @QMUL discuss the emerging knowledge of the molecular composition and function of mitochondrial–nuclear contact sites in eukaryotes, including recent work by @JanaOvciarikova @SheinerLab et al. (hubs.la/Q02v9q590): hubs.la/Q02v9mBl0
Ward, Vangala, Kamber Kaya, Radhakrishnan et al @VCU show that in addition to its role as a positive regulator of #proteasome genes, the transcription factor Nrf1/NFE2L1 can also induce #autophagy–lysosomal pathway genes & drive autophagic flux hubs.la/Q02tZ1CK0
Wang, Lu et al. @CincyChildrens demonstrate the critical role of BRG1/SMARCA4 for #oligodendrocyte precursor cell differentiation and remyelination hubs.la/Q02tPfbS0
We are extremely happy to see our work published in @JCellBiol where we show how #UBAP2L promotes assembly and stability of nuclear pore complexes #NPCs during interphase. Thank you to @YongrongL and all authors and reviewers for an amazing job! 🙏🥳🤩 rupress.org/jcb/article/22…
.@YongrongL et al. @SumaraLab @IGBMC show how UBAP2L facilitates assembly and stability of mature NPCs at the nuclear envelope during early interphase to ensure efficient nuclear transport, adaptation to nutrient stress, & cellular proliferative capacity hubs.la/Q02tP01h0
Spotlight: Antonio Galindo @MRC_LMB highlights new results from Assaad, Wiese, and colleagues (hubs.la/Q02tNDbj0) showing how the TRAPPII complex orchestrates growth decisions when resources are limiting. hubs.la/Q02tNCmS0 #PlantBiology #Trafficking
Determinants of minor satellite RNA function in chromosome segregation in mouse embryonic #StemCells. A new study from Yung-Li Chen, Andreas Ettinger, Maria-Elena Torres-Padilla (@METorresPadilla) et al @HelmholtzMunich: hubs.la/Q02t0S800 #CellDivision #centromeres
OMA1 clears traffic jam in TOM tunnel in mammals. Shiori Sekine and Yusuke Sekine @AgingPitt discuss the work by Krakowczyk et al. (hubs.la/Q02sSPX90) in Spotlight ➡️ hubs.la/Q02sSKgC0 #Organelles #mitochondria
Molecular Cell @MolecularCell
125K Followers 582 Following Molecular Cell is a Cell Press journal that aims to publish the best papers in molecular biology.American Society for .. @ASCBiology
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7K Followers 1K Following Journalist at Nature. Mostly listening. Get in touch: [email protected]I emphasize this again because its such an excellent article.
Going steady for maturity: a subset of CD63-rich #endosomes partner with #microtubule-associated #septins, which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New from @SeptinLab @drexel_coas @UVa_CellBio: hubs.la/Q02v9FQ30
Some great new insights into nucleocytoplasmic transport.
Scott, Roux et al. @SanfordResearch show that changes in the availability of cellular GTP resulting from physiologically relevant processes, including cell migration and cell spreading, alter the rates of Ran-dependent nuclear import and export. hubs.la/Q02vl-6l0
Great to share new insights into diarrhea disease models with JCB readers! @VanderbiltCDB @EBCVanderbilt
New Review: @iKajiLab, @JRTlab and @GoldenringLab @VUMChealth discuss recent findings in cell, organoid, and animal models for monogenic diseases causing congenital diarrhea and enteropathies (CODEs). hubs.la/Q02vmpq30 #Disease #Physiology #Trafficking
Mitochondrial–nuclear contact sites in eukaryotes!
Viewpoint: Campanella and Kannan @QMUL discuss the emerging knowledge of the molecular composition and function of mitochondrial–nuclear contact sites in eukaryotes, including recent work by @JanaOvciarikova @SheinerLab et al. (hubs.la/Q02v9q590): hubs.la/Q02v9mBl0
Congrats to Dr. Ben Robinson (not on twitter) and my PhD mentor @SeptinLab for putting out a beautiful and complex story of endosome maturation!
Going steady for maturity: a subset of CD63-rich #endosomes partner with #microtubule-associated #septins, which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New from @SeptinLab @drexel_coas @UVa_CellBio: hubs.la/Q02v9FQ30
New news! Our latest (preprintless) story on MVB maturation taking place on a subset of septin-coated microtubules. Ben Robinson's PhD thesis and the last opus from my 15-year Drexel residency. A tweetorial to follow.
Going steady for maturity: a subset of CD63-rich #endosomes partner with #microtubule-associated #septins, which promote maturation to multivesicular bodies/late endosomes by inhibiting their motility. New from @SeptinLab @drexel_coas @UVa_CellBio: hubs.la/Q02v9FQ30
Congrats to first-authors Sonja Achleitner, Verena Baumann, and @susanna_tulli (@martens_sascha lab) on their recently published paper in @JCellBiol 🥳 Their study shows that Faa1 is crucial for autophagosome formation and autophagosome maintenance 💡 Watch their #SuccessStory ➡️
Manuscript accepted and @JCellBiol for the turnaround time win. Time from submission, review, resubmission, re-review, acceptance: 82 days! Just in time for @WormGuyKade to start his postdoc with @maxwellheiman
We are extremely happy to see our work published in @JCellBiol where we show how #UBAP2L promotes assembly and stability of nuclear pore complexes #NPCs during interphase. Thank you to @YongrongL and all authors and reviewers for an amazing job! 🙏🥳🤩 rupress.org/jcb/article/22…
📢 #PaperAlert Congratulations to #HelmholtzMunich expert Prof. Maria-Elena Torres-Padilla @JCellBiol👇
Chen, @METorresPadilla et al. @HelmholtzMunich investigate how the correct balance of centromeric transcripts from mouse stem cells affects #chromatin recruitment of CENPC & propose a model where structural RNA features are key for RNA–protein interactions hubs.la/Q02t0Jnf0
Interesting.
The cadherin–catenin linkage has been considered the keystone of junctional force transmission, but new findings challenge this paradigm. Sebbagh @univamu and Schwartz @YaleMed discuss new research in this Viewpoint: hubs.la/Q02rw8QM0
Thrilled to share that our paper showing how tissues regulate #proteasome content in vivo is now accepted for publication @JCellBiol! Congratulations to our talented postdoc @JenniferGilda (now in Genentech) and PhD student @KDharanibalan for their remarkable work! #muscle 📷
My San Diego journey continues w a visit at UCSD 🥳 Meeting a few @JCellBiol board members and some of the many excellent scientists here!
A new study from the 🔬 @Jamora_lab uncovered a novel function of caspase-1, a protein classically known as an integral component of the cytosolic #inflammasome. Read about their findings in 📚 @JCellBiol! 👉 bit.ly/3JcrM8n
thrilled to share our latest review discussing presynaptic perspectives of neurodevelopmental disorders by focusing on impaired axonal transport and disturbed assembly and maintenance of presynapses. hubs.la/Q02rGTT70
Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders. New review from Gui-Jing Xiong and Zu-Hang Sheng (@zuhangsheng) @NIH_NINDS: hubs.la/Q02rGQwY0 #Trafficking #Neuroscience
Phosphatidylserine externalization is a marker for PM damage. However, PS synthesis and trafficking are also important for PM repair, in part through prompting the assembly of Tspn4 rings to limit the size of the damage.
Image shows how phosphatidylserine facilitates Tspan4 accumulation at damage sites. From Li, Norris, @rob8yang et al. @UNSW demonstrating that the mobilization of phosphatidylserine to sites of membrane damage aids the assembly of tetraspanin rings. hubs.la/Q02qM0MC0
Congratulations...
Hegde, Ghosh et al. @Jamora_lab @DBT_inStem report that extracellular Caspase-1 functions as a chemotactic factor. They solve the question of the cue(s) that coax the migration of HFSCs into the epidermis in #woundhealing & inflammatory skin conditions. hubs.la/Q02s92fb0
Stain phosphoinositides in fixed cells and tissues: now in its final form in my favourite journal @JCellBiol ! Super proud of the first work from my independent lab and hope it will be useful to the community rupress.org/jcb/article/22… All plasmids here: addgene.org/Hannes_Maib/
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Logistics of defense: The contribution of endomembranes to plant innate immunity. New review from Deepak Bhandari (@Deepak_ddb) and Federica Brandizzi (@msubrandizzilab) @MSUDOEPlantLab @michiganstateu: hubs.la/Q02r8_YK0 #PlantBiology #Disease #Trafficking