Jason Miller @JasonMLMiller
RPE biologist and physician scientist studying the pathogenesis of dry macular degeneration. Passionate about mentorship, science, patients, and family. sites.google.com/umich.edu/jaso… Kellogg Eye Center, UofMich. Joined August 2021-
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Thankful that graduate students are talking about the sheer feeling of doom and chaos that exists in American science right now. A large part of America's innovation can be traced to education and research from our universities and that is being wiped away.
Thankful that graduate students are talking about the sheer feeling of doom and chaos that exists in American science right now. A large part of America's innovation can be traced to education and research from our universities and that is being wiped away.
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Impromptu peroxisome interest club at ARVO.
A piece of great news. We will look for small molecule inducers of RPE autophagy that do not directly inhibit mTOR as a therapeutic for dry AMD (mTOR inhibition is not great for RPE health). And then study better ways to get inducers to the RPE in vivo.
A piece of great news. We will look for small molecule inducers of RPE autophagy that do not directly inhibit mTOR as a therapeutic for dry AMD (mTOR inhibition is not great for RPE health). And then study better ways to get inducers to the RPE in vivo.
At the Ryan Initiative for Macular Research (RIMR - rimr.doheny.org), we discussed whether AMD is one or multiple diseases. TLDR: There are key subtypes, but they blend into each other and we need more sophisticated analysis to better distinguish. tinyurl.com/3dwb27se
We sought a better marker of basal polarized secretion in the RPE, compared to VEGF (low abundance) and TIMP3 (multiple bands on WB). With some bioinformatics on existing datasets, we found IGFBP5! Highly expressed, highly polarized to basal side. tinyurl.com/mvxue2vy
Thanks to @RPB_org [bit.ly/RPBgrant] for a career development award to study the cross-talk between mitochondria and peroxisomes in handling lipids in the RPE, and ways to harness peroxisomal capacity as a therapeutic for AMD.
My social media early vote-by-mail sticker. Thought this was a cool design, all the cool local Ann Arbor attractions.
Thanks to Hurley lab and @DanielH155 for allowing us to participate in this project (jbc.org/article/S0021-…). If you push RPE to degrade lipids in the mitochondria, it may secrete less drusen-promoting components, a novel strategy for treating intermediate AMD.
Thanks to Hurley lab and @DanielH155 for allowing us to participate in this project (jbc.org/article/S0021-…). If you push RPE to degrade lipids in the mitochondria, it may secrete less drusen-promoting components, a novel strategy for treating intermediate AMD.
Graduate student Kaitlyn Digbsy (@katie_digs) posted the following to lab SLACK channel today, under the title "Picasso" 🎨. Oh simple Western blot - where art thou sensibilities?
In record time, our pub on RPE ketogenesis is out. Main takeaways: B-HB is not a pure marker of beta-oxidation in the RPE (amino acids abundantly make B-HB) and enzymatic kits do not accurately detect RPE B-HB. You need to do mass spec to detect. tinyurl.com/3wzufwwn
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