Daniel Kerschensteiner @KLabVision
Prof @WUSTL. Vice-Chair @WustlDOVS. Co-Director #WashUNeuroPhD. To understand, preserve, and restore vision. kerschensteinerlab.wustl.edu Saint Louis, USA Joined August 2021-
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A @NeuroCellPress paper led by Kushal @UCBerkeley, Nicole&Victoria @UCSF in full collaboration with @shekharlab, Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma sciencedirect.com/science/articl… #retina #MERFISH
A @NeuroCellPress paper led by Kushal @UCBerkeley, Nicole&Victoria @UCSF in full collaboration with @shekharlab, Molecular and spatial analysis of ganglion cells on retinal flatmounts identifies perivascular neurons resilient to glaucoma sciencedirect.com/science/articl… #retina #MERFISH
Finally it's out! nature.com/articles/s4158… Thanks to Felix Baier, Karl Farrow and Hopi Hoekstra! And a big thank you to all the co-authors, reviewers, host institutes and funding sources! @BramNuttin, Arnau Sans Dublanc, Chen Liu, Victoria Tong, Julie Murmann and Keimpe Wierda
Finally it's out! nature.com/articles/s4158… Thanks to Felix Baier, Karl Farrow and Hopi Hoekstra! And a big thank you to all the co-authors, reviewers, host institutes and funding sources! @BramNuttin, Arnau Sans Dublanc, Chen Liu, Victoria Tong, Julie Murmann and Keimpe Wierda
We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! nature.com/articles/s4146…
Join us in congratulating professor Susan K. Dutcher, PhD, on her election to the National Academy of Sciences. Her groundbreaking research on cilia is unlocking insights into chronic disease and continues to elevate WashU Medicine’s legacy of scientific excellence and impact.
65 years after Lettvin’s bug detector neurons in the frog retina, we revisit how the retina drives behavior—from reflexes to prey capture to brain-state modulation New review with @AnnaIntegrated & Serena Riccitelli in Annual Review of Vision Science 👇 tinyurl.com/ymp3vs4d
ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on @Addgene addgene nature.com/articles/s4159… Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators, @blsabatini @Kanoski_Lab @vincentw_weng @beherring
Happy to share our recent work on a conductance that shapes substantially the output of rod photoreceptors. The role of the Ca2+-activated Cl- conductance in the membrane potential and light response of mouse rods jneurosci.org/content/early/…
We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s4146…
1/ Why do late-stage cancer patients lose motivation & sink into apathy? 🔥Our new Science paper shows cancer activates a cytokine-sensing brain circuit to lower motivation.Great work by Aelita Zhu @sarahstarosta @Pignatelli_Lab @JanowitzTobias &team!🧵 🔗 doi.org/10.1126/scienc…
Our RUVBL2 paper is online published by Nature: trebuchet.public.springernature.app/get_content/8a…
Research from @KLabVision published in @PNASNews, reveals how mice use vision to #hunt! 🐭🔬 Jenna Krizan, PhD, and colleagues revealed that some neurons in the superior colliculus inherit their motion-sensitive signaling patterns from the #retina. #eyes ophthalmology.wustl.edu/the-role-of-di…
Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward. pnas.org/doi/epub/10.10…
Excited to present the result of a fantastic collaborative effort - funded by the National Institutes of Health, including the NIH HEAL Initiative, to develop safer analgesic drugs. nature.com/articles/s4158…
We must learn to showcase the practical significance of basic research, demonstrating how seemingly arcane investigations yield transformative applications, writes @TonyZador. thetransmitter.org/outreach/how-t…
Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. 1/3
Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. 1/3
Excited to share our latest study! 🧠✨ We reveal how non-direction-selective retinal ganglion cells encode motion beyond their receptive field, relaying the unconventional signals to the brain. A new insight into multimodal neurons in visual processing! pnas.org/doi/10.1073/pn…
Here, we present a powerful, flexible tool that expands the reach of genetic screens to a wealth of previously inaccessible biological questions. We encourage our colleagues to reach out for protocols, reagents, etc. nature.com/articles/s4155…
Our paper, "The promise and peril of comparing fluorescence lifetime in biology revealed by simulations", is now on @eLife: doi.org/10.7554/eLife.…. Hope readers will use our package to design and interpret FLIM experiments rigorously, and also give us feedback.
Our paper, "The promise and peril of comparing fluorescence lifetime in biology revealed by simulations", is now on @eLife: doi.org/10.7554/eLife.…. Hope readers will use our package to design and interpret FLIM experiments rigorously, and also give us feedback.
Our paper "GABAergic amacrine cells balance biased chromatic information in the mouse retina" is now published in @CellReports cell.com/cell-reports/f…
Our paper "GABAergic amacrine cells balance biased chromatic information in the mouse retina" is now published in @CellReports cell.com/cell-reports/f…

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