Kleger Lab @KlegerLab

We are a team of scientists and physicians 🇩🇪🇦🇹🇫🇷🇮🇳🇺🇸 passionately working on #stemcells #organoids #cancer #pancreaticcancer @UniKlinikUlm. Est. 2009 kleger-imos.com Ulm, Germany Joined October 2020

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Kleger Lab @KlegerLab

11 months ago

Visit the @KlegerLab under kleger-imos.com and consider striving your career with us ! looking forward to receive your applications for PhD and/or postdoc !

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As #SarahMerz moves on to a postdoc with #DiegoBalboa at the #UniversityofHelsinki, we are excited to announce that we are recruiting the next generation of PhD students to join our successful team at #IMOS! 🌟 Let’s continue pushing the boundaries of diabetes research together!

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Kleger Lab @KlegerLab

11 months ago

A special thanks to #MaureenGannon for summarizing both our studies in a fantastic preview article in #CellReports titled “CUTting through the distance - A disease-relevant long-range ONECUT1 enhancer.” doi.org/10.1016/j.celr… Your support is invaluable!

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Kleger Lab @KlegerLab

11 months ago

We also explored in vitro therapeutic options for affected patients and linked a low-frequency variant to type 2 diabetes. Excitingly, the #DanweiHuangfuLab utilized CRISPRi screening during pancreatic differentiation, confirming our findings regarding the same enhancer.Congrats!

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Kleger Lab @KlegerLab

11 months ago

Here, we identified a disease-causing deletion upstream of OC1 in compound heterozygosity with an OC1 mutation in an affected individual, while investigating its functional role as a cis-acting enhancer influencing OC1 expression during pancreatic development.

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Kleger Lab @KlegerLab

11 months ago

Building on this foundation, we're excited to announce our latest publication in #CellReports! Brilliant #SarahMerz completed her PhD with her second first authorship under the guidance of #SandraHeller, alongside #CecileJulier and me (doi.org/10.1016/j.celr…).

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Kleger Lab @KlegerLab

11 months ago

We then discovered that OC1 coding mutations are associated with various forms of diabetes as modeled via pluripotent stem cell differentiation, details in #NatureMedicine (doi.org/10.1038/s41591…).

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Kleger Lab @KlegerLab

11 months ago

Our journey began with characterizing the regulatory patterns of ONECUT1 (OC1) during pancreatic lineage commitment, published in #CommunicationsBiology (doi.org/10.1038/s42003…).

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Kleger Lab @KlegerLab

11 months ago

🚀 I am thrilled to add another piece to the “ONECUT1 diabetes” puzzle, again with joint forces between the #JulierLab at #INSERM and the collaborative efforts #IvanCosta, the Institutes of #HumanGenetics and #TransfusionMedicine at #UlmUniversity, and other collaborators!

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GSCN @gscn_office

2 years ago

Freier Eintritt zur Podiumsdiskussion "Stammzellen - die Alleskönner" mit Wissenschaftler*innen zu Themen von Alterung bis Krebs. Wie ist der Stand der Forschung bei Zelltherapien? Am 15.9. in der vh Ulm. Info: gscn.org/public-resourc… @stadtulm @KlegerLab #stammzellen

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Kleger Lab @KlegerLab

2 years ago

Our commenting summary just published in Cell Stem Cell doi.org/10.1016/j.stem…

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Kleger Lab @KlegerLab

2 years ago

Great work by the Wang lab: there is much heterogeneity in our beloved pancreas, congrats Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis: Cell Stem Cell cell.com/cell-stem-cell…

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Kleger Lab @KlegerLab

2 years ago

Congrats to work by the Wang lab, there is so much heterogeneity in our beloved pancreas! Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis: Cell Stem Cell cell.com/cell-stem-cell…

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Kleger Lab @KlegerLab

2 years ago

#klegerlab at kleger-imos.com is hiring again...looking forward to get your applications

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Costa Lab - @costalab.bsky.social @vanvanka123

2 years ago

@DKG_Berlin @UniklinikEssen @UniklinikUlm @chr_reinhardt @KlegerLab @KlegerLab Congrats Alex!

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Kleger Lab @KlegerLab

2 years ago

Deeply honored to receive the prestigious deutscher-krebspreis.de from @DKG_Berlin in the experimental category together with @chr_reinhardt for our work at kleger-imos.com Thanks to the entire @KlegerLab @uni_ulm @UniklinikUlm and our friends and collaborators

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Rüdiger Groß @r_gross_

2 years ago

@DanielBachurski @KennethWWitwer Vielen Dank dir!

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Kleger Lab @KlegerLab

3 years ago

We are recruiting again at kleger-imos.com to conduct our @organoid and @stemcell based research projects. Looking forward to receive applications. JOIN us at @imos

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Kleger Lab @KlegerLab

3 years ago

I am happy to announce that we have finished our new homepage illustrating the recently founded Institute of Molecular Oncology and Stem Cell Biology - short #imos kleger-imos.com. .