The Lehtiö Lab @LabLehtio
Structural and Chemical Biology team at the Faculty of Biochemistry and Molecular Medicine, University of Oulu. Lab account but tweets from Lari #unioulu #fbmm oulu.fi/en/research-gr… Oulu, Suomi Joined February 2020-
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Tutkijamme ovat onnistuneet kehittämään yhdisteen, joka estää koronaviruksen lisääntymisen ihmissoluissa. Yhdiste on tuoreiden tutkimustulosten perusteella erittäin lupaava aihio koronaviruslääkkeiden kehitykseen. #UniOulu #koronavirus @LabLehtio oulu.fi/fi/uutiset/oul…
Mac1 inhibitor represses #SARSCoV2 replication! #PARP #drugdiscovery @FehrLab doi.org/10.1021/acs.jm…
Our paper on oligomerization of DTX3L E3 ubiquitin ligase and how this allows DTX3L-PARP9 compex to recognize ADP-ribosylated proteins is now online in Protein Science. Structure was solved with sulphur SAD @DiamondLightSou #PARP #BiocenterOulu #UniOulu dx.doi.org/10.1002/pro.49…
Our paper on #PARP HPF1 interaction inhibitors and assay is now online. Mainly some validation with full-length enzyme and activity added to the preprint version. nature.com/articles/s4159…
Small contribution from us to a collaborative study on the design of new small molecule inhibitors. Naturally using #PARP as an example. #fbmm #biocenteroulu onlinelibrary.wiley.com/doi/10.1002/mi…
@UniOulu @LabLehtio tekemälle #parp lääkeaihiokeksinnölle on myönnetty #patentti Euroopassa. Kyseessä on pienimolekyylinen kemiallinen yhdiste, joka tehostaa syövän hoitoa, kun sitä annetaan soluille yhdessä solumyrkkyjen kanssa. ➡ Lue lisää - linkki kommenteissa #oulu
A doctoral researcher position available in our team focusing on mono-ART's and their complexes. #PARP #fbmm #structuralbiology oulunyliopisto.varbi.com/en/what:job/jo…
How does #DTX3L oligomerize and why is it needed? A preprint about this is online #fbmm #biocenteroulu #PARP doi.org/10.1101/2023.1…
A different kind of preprint. This is about the MSc crystallography course we organize in Oulu. Actually at the moment the R-factors start to be below 20% for some students :) #fbmm #biocenteroulu @UniOulu doi.org/10.35542/osf.i…
A preprint is available about the HTS assay to find inhibitors for #PARP HPF1 interaction developed and carefully optimized by @SaurabhSinghDh8 . We even found some early hit molecules. #drugdiscovery #FBMM #BiocenterOulu @SuomenAkatemia doi.org/10.1101/2023.1…
How DTX3L-PARP9 complex can bind dual ADP-ribosylated peptides? Nice collaboration paper with @LeidenADPr and Paschal team. #BiocenterOulu #PARP #FBMM pubs.acs.org/doi/10.1021/ac…
Saurabh is representing our team! The course is likely extremely nice based on the programme and the picture.
We have 3 doctoral researcher positions available in projects studying human mono-ADP-ribosyltransferases. These are funded by the #BiocenterOulu spearhead project and by the Research Council of Finland. @SuomenAkatemia @UniOulu #PARP #FBMM oulunyliopisto.varbi.com/en/what:job/jo…
A preprint now available for the macrodomain inhibitor which inhibits coronavirus replication. Great collaboration between teams from @UniOulu, @UnivOfKansas and @McDanielCollege #PARP #Drugdiscovery #SARSCoV2 doi.org/10.1101/2023.0…
The paper on the FRET-assay and discovery of DTX3L E3 ligase inhibitors is now published. Congrats and big thanks especially to Carlos! #BiocenterOulu #UniOulu #drugdiscovery #LifelongHealth doi.org/10.1016/j.slas…
Lloyd Ruddockille tutkimuksen kaupallistaminen näyttäytyi pitkään Tähtien sodasta tutun pimeän puolen kaltaisena pahana voimana. Nyt hän kertoo työskennelleensä jo yli vuosikymmenen ajan yritysten kanssa yhteistyössä. Mikä sai mielen muuttumaan? #UniOulu oulu.fi/fi/uutiset/aka…
We had an incredible time at the PARP2023 advanced course! 🌟 Engaging talks, thought-provoking discussions, and inspiring connections made. Already reminiscing about the fantastic moments! Looking forward to reconnecting with all of you in Strasbourg 2025. #PARP2023
Paljon onnea Oulun yliopiston Biokemian ja molekyylilääketieteen tiedekunnan uusille LuK:lle!
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