Tiwari Lab @LabTiwari
Deciphering epigenetic mechanisms and transcription factors that wire gene expression programs tiwarilab.org Joined October 2020-
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Junior #CancerSymposium 2025 Hosted by the Translational Cancer Hub at #SDU University We were thrilled to welcome bright young minds to the Junior Cancer Symposium — a day filled with inspiring talks, innovative research... Read more: tiwarilab.org/f/junior-cance… #TiwariLab
Brain metastases (BrMs) present a major challenge in cancer treatment, with limited molecular profiling to date. This study applies integrative single-cell RNA sequencing to 108 BrMs and 111 primary tumors across... Read more: tiwarilab.org/f/pan-cancer-h… #TiwariLab #JournalClub
This study presents a groundbreaking exploration into the complexities of gene regulation. Utilizing the innovative CAP-SELEX technique, researchers mapped over 58,000 transcription factor (TF) pairs, uncovering... Read more: tiwarilab.org/f/dna-guided-t… #TiwariLab #JournalClub
In this study, the authors introduced a novel method—multi-omics single-cell optimal transport (Moscot). Compared to traditional optimal transport (OT) approaches, moscot offers three key technical advancements: multi... Read more: tiwarilab.org/f/mapping-cell… #TiwariLab #JournalClub
The immune checkpoint blockade (ICB) therapies have shifted the treatment paradigm for non-small-cell lung cancer (NSCLC), many patients remain resistant. In this study, the authors integrate scRNA-seq (>200K cells)... Read more: tiwarilab.org/f/multi-omic-p… #TiwariLab #JournalClub
This paper introduces DEPLOY, a deep learning model designed to enhance the diagnosis of central nervous system (CNS) tumors. Accurate diagnosis of CNS tumors is critical for effective treatment... Read more: tiwarilab.org/f/prediction-o… #TiwariLab #JournalClub
In this study, the authors found that Rela/NF-κB activation reprogrammed microglia into a pro-inflammatory phenotype, which enhanced antitumor immunity and reduced MBM burden. Read more: tiwarilab.org/f/microglial-r… #TiwariLab #JournalClub
This interesting article presents a novel approach by using CRISPR-Cas9 to knock out over 20,000 genes across human cell lines, creating a genome-wide map of how gene perturbations influence cell morphology. Read More: tiwarilab.org/f/a-genome-wid… #TiwariLab #JournalClub
#SDU and #OUH Celebrate the Launch of the Center for Integrated Multi-Omics in Precision Medicine (#CIMP). Read more: tiwarilab.org/f/sdu-and-ouh-… #TiwariLab
This study functionally validated cross-disorder GWAS loci, identifying regulatory variants (emVars) and their target genes using eQTLs and chromatin architecture. Read more: tiwarilab.org/f/massively-pa… #TiwariLab #JournalClub
ICYMI: By using SEEG electrodes from epilepsy patients to gather RNA, DNA & protein data, @LabTiwari @SyddanskUni reveals unique molecular profiles tied to brain activity--potentially improving epilepsy diagnosis and treatment... insight.jci.org/articles/view/…
This study provides a comprehensive multi-omic atlas of the developing human neocortex, spanning five developmental stages from the first trimester to adolescence. Read more: tiwarilab.org/f/molecular-an… #TiwariLab #JournalClub
Souren works on uncovering the molecular mechanisms of a gene marker that seems to be associated with Autism Spectrum Disorder. Youtube link: youtube.com/watch?v=IjHO5y… Read more: tiwarilab.org/f/tiwarilab-so… #TiwariLab
An interesting study that introduces the General Expression Transformer (GET), an advanced foundation model designed to unravel transcriptional regulation mechanisms across diverse human cell types. Read more: tiwarilab.org/f/a-foundation… #TiwariLab #JournalClub
Our new study with @LabTiwari is now out in full in JCI Insight! A new way to study gene activity and its links to epileptic networks in the human brain. insight.jci.org/articles/view/…
By using SEEG electrodes from epilepsy patients to gather RNA, DNA & protein data, @LabTiwari @SyddanskUni reveals unique molecular profiles tied to brain activity--potentially improving epilepsy diagnosis and treatment... insight.jci.org/articles/view/…
This study introduces a comprehensive human neural organoid cell atlas created from 1.7 million cells across 36 single-cell transcriptomic datasets and 26 protocols. Read more: tiwarilab.org/f/an-integrate… #TiwariLab #JournalClub
A groundbreaking study from our lab "Pan-cancer drivers of metastasis", led by our PhD student Ryan Lusby, reveals critical insights into the mechanisms driving cancer metastasis-the leading cause of cancer-related deaths. Read more: tiwarilab.org/f/pan-cancer-d… #TiwariLab
In this study, researchers employed spatial transcriptomics to investigate the tumor architecture and microenvironment of triple-negative breast cancer (TNBC) in 92 patients. Read more: tiwarilab.org/f/spatial-tran… #TiwariLab #journalClub
Delighted to announce MoPEDE - a great collaboration with @LabTiwari proving you can measure gene activity in the human brain using mRNA and DNA methylation from the surface of explanted depth electrodes and integrate with neurophysiology! insight.jci.org/articles/view/…
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