Lisa Schweizer @LisaCSchweizer
Joined June 2020-
Tweets86
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Following153
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Exciting new #DVP study on the origins of high-grade serous ovarian cancer (#HGSC). Extracting as few as 12 mutated cells from precursor lesions and profiling consecutive tumorigenesis, this study took a formidable technical challenge and identified novel therapeutic targets.
New preprint reveals why IDO1 inhibitor trials failed! Led by Peter Murray @MPI_Biochem, our collaboration discovered IDO1 actually kills ovarian cancer cells via GCN2/ISR pathway - not protecting them. Spatial proteomics uncovers unexpected biology. biorxiv.org/content/10.110…
Check out the current issue of @Cancer_Cell featuring our work on the malignant progression of borderline ovarian tumors on its cover. A team effort between @OvCa_UChicago @uchicago_obgyn and @labs_mann @MPI_Biochem.
Check out the current issue of @Cancer_Cell featuring our work on the malignant progression of borderline ovarian tumors on its cover. A team effort between @OvCa_UChicago @uchicago_obgyn and @labs_mann @MPI_Biochem.
Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TMSCHQ
Excited to see this masterpiece out @Nature today. In this study, @JannaHeide, @AndrasPiffko, @ErnstLengyel & colleagues @OvCa_UChicago unraveled molecular mechanisms of NNMT in ovarian cancer and developed a specific inhibitor. A highly promising therapeutic avenue.
Excited to see this masterpiece out @Nature today. In this study, @JannaHeide, @AndrasPiffko, @ErnstLengyel & colleagues @OvCa_UChicago unraveled molecular mechanisms of NNMT in ovarian cancer and developed a specific inhibitor. A highly promising therapeutic avenue.
New study from @rweichselbaum and team show high-dose radiation triggers amphiregulin, a protein that weakens immunity and fuels distant cancer spread—pointing to new strategies for blocking its effects. @SeanPitroda @AndrasPiffko @UChicagoRadonc @Nature ow.ly/HgVU50Wn6ZY
Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with @OmicVision @MundAndreas Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!
New @biorxivpreprint ! With Dr. Maitra @Aiims1742 (@MDAndersonNews) & Nebraska Rapid Autopsy Program, we used AI-powered Deep Visual Proteomics to map early molecular changes in pancreatic cancer precursor lesions. Read: bit.ly/4nAqPK8 #SpatialMedicine #PDAC
📢 New in Cancer Cell: Radiotherapy is essential for local control—but can it unintentionally accelerate growth of distant metastases? We examine how RT-induced EGFR signaling and immune modulation may fuel metastatic progression. 🧠🧬🔬 Read: doi.org/10.1016/j.ccel…
Exciting opportunity for a postdoc position with the exceptional @NordmannThierry on the topic of inflammatory skin disease. A great and inspiring environment that I can highly recommend!
Exciting opportunity for a postdoc position with the exceptional @NordmannThierry on the topic of inflammatory skin disease. A great and inspiring environment that I can highly recommend!
Online Now: Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression dlvr.it/TLbW6y
Proud to share our latest work now in @Cancer_Cell. In collaboration with @MPI_Biochem, we map the progression from borderline ovarian tumors to low-grade serous ovarian cancer & propose a promising new therapeutic strategy. sciencedirect.com/science/articl… #LGSC #SBT
An interdisciplinary study @labs_mann & @uchicago_obgyn uncovers how benign borderline ovarian tumors develop into invasive low-grade serous carcinoma, opening a new avenue for targeted therapy. ❕Publication: cell.com/cancer-cell/fu… ❕Press Release: biochem.mpg.de/when-tumors-tu…
A new publication in @Cancer_Cell uncovers how borderline ovarian tumors evolve into low-grade serous ovarian cancer & identifies a promising new treatment strategy. Read: bit.ly/4luXCP8 @UCCancerCenter @LisaCSchweizer @hkenny228 @ErnstLengyel @labs_mann @MPI_Biochem
Happy to share our preprint in collaboration with the Lundberg Lab revealing spatial heterogeneity in human pancreatic islets with multiplexed Deep Visual Proteomics. Grateful for the fantastic team and collaboration!
Happy to share our preprint in collaboration with the Lundberg Lab revealing spatial heterogeneity in human pancreatic islets with multiplexed Deep Visual Proteomics. Grateful for the fantastic team and collaboration!
Check out our @Nature review with Tiannan Guo @guomics and Judith Steen @ionicwoman on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI nature.com/articles/s4158…
After 4 fantastic years of research, with @caina89 & @heinig_matthias, I’m thrilled to share the first tissue specific map of apparent mtDNA heteroplasmy in humans and their relationships with donor age and mtDNA gene expression across 49 human tissues!👇 biorxiv.org/content/10.110…
Exciting news - Spatial Proteomics is @naturemethods’ 2024 Method of the Year! Our commentary highlights how Deep Visual Proteomics (DVP) unites imaging, data science & high-res proteomics at single-cell resolution, fueling predictive tissue models and personalized medicine. Stay…
Exciting news - Spatial Proteomics is @naturemethods’ 2024 Method of the Year! Our commentary highlights how Deep Visual Proteomics (DVP) unites imaging, data science & high-res proteomics at single-cell resolution, fueling predictive tissue models and personalized medicine. Stay…

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