Gabriel Loeb @LoebLab

Seeking molecular mediators of kidney disease through human genetics, genomics, and novel experimental models. @UCSF, @UCSFNephrology Joined August 2022

Tweets

22
Followers

45
Following

55
Likes

6

Gabriel Loeb @LoebLab

2 months ago

Thank you @ASNKidney! Our lab is very grateful to receive the 2025 Carl W. Gottschalk Research Scholar Grant. Read more about the work here: kidneycure.org/pages/qa.aspx?….

3 0 10 748 0

#Whyscience Day51🧠✨A strong finish to our Renal Grand rounds series by a rising star physician scientists ⁦@LoebLab⁩ ⁦@UCSFNephrology⁩ Pushing the frontiers of kidney genomics and single cell omics. The future of nephrology is bright🔆

1 4 27 2K 2

Download Image

Gabriel Loeb @LoebLab

11 months ago

Exciting paper by @CanaudLab in @jclinicalinvest--doi.org/10.1172/JCI176…. 1) Somatic mutation as a (presumably) very rare cause of FSGS, 2) Targeting the mutated gene PIK3CA is helpful in multiple mouse FSGS models, 3) Activity of podocyte targeted therapy in mouse FSGS.

0 1 2 1K 0

Maze Therapeutics @MazeInBiotech

11 months ago

We are pleased to announce that the first participant has been dosed in our Phase 1 clinical trial evaluating MZE782. MZE782 is a potentially first-in-class, oral, small molecule targeting the solute transporter, SLC6A19, and has the potential to address chronic #kidneydisease…

2 4 10 2K 0

Download Image

Veera Rajagopal  @doctorveera

12 months ago

Great paper that dissects the genetics of kidney function by combining GWAS results with data from single cell ATAC sequencing of kidney tissue. The authors make a strong case for the majority of the heritability of polygenic traits come from a small portion of disease-relevant…

3 19 79 7K 48

Download Image

UCSF Nephrology @UCSFNephrology

12 months ago

Very important new study out today by Gabe Loeb, MD, PhD, Assistant Prof : 56% of kidney function heritability localized to kidney tubule epithelial cis-regulatory elements! @ReiterLab @UCSF @UCSFDOM nature.com/articles/s4158…

2 7 19 2K 2

Reiter Lab @ReiterLab

12 months ago

Please read and critique our new paper on the genetic determinants of human kidney function @NatureGenet: rdcu.be/dTwye We combined GWAS with CNN and CRISPRi to go from loci to target genes. This roadmap may be useful to others uncovering genes underlying human traits.

4 11 55 5K 10

Download Image

Gabriel Loeb @LoebLab

3 years ago

A missense variant in a high risk APOL1 allele ameliorates risk of kidney disease in humans and also blocks channel function, solid human genetic evidence that channel activity —>pathogenesis. Amazing from @ahungkidney and @MazeInBiotech at #KIDNEYWEEK2022.

0 0 1 0 0

Emilie Cornec-Le Gall @ecorneclegall

3 years ago

Nephrogenetic session #KidneyWk Prof Jan Halbritter from @ChariteBerlin advocates for recognizing CKD unknown (or not yet diagnosed) as a diagnosis. Let's get ride of hypertensive Nephropathies/or other unspecific diagnosis!