The FDA is sitting on a goldmine of drug development data ā 10,000+ page dossiers detailing how drugs are designed, made, tested, and approved.
Big Pharma has these in-house. Startups? Locked out.
Itās time to fix that. Read my proposal for @IFP on how.
ifp.org/biotechs-lost-ā¦
New article by me!
Cardiovascular disease mortality rates have declined by around three-quarters since 1950, but we rarely hear about it.
I explore some of the reasons behind the decline.
Interesting new way to model rejuvenation!
āAnnealing restores old metals by heating then a slow cooldown. This relieves internal stresses. We propose that aged, unhealthy cells can anneal similarly: a mild shock allows the cell to rapidly re-anneal to the optimal state.ā
Interesting new way to model rejuvenation!
āAnnealing restores old metals by heating then a slow cooldown. This relieves internal stresses. We propose that aged, unhealthy cells can anneal similarly: a mild shock allows the cell to rapidly re-anneal to the optimal state.ā
Peak Faraday humour on @xkcd!
The farad is a VERY LARGE unit of electrical capacitance (the ability of a body to store an electrical charge).
Your typical capacitor for electronic applications will have 1 picofarad to 100 microfarads capacity.
Credit: xkcd.com/3106/
Level 1: Tackling individual hallmarks of aging, like metabolic health or inflammation (adding years to life).
Level 2: Stabilizing biological systems against random fluctuationsāreducing physiological ānoiseā that destabilizes health as we age (adding decades of healthy life).ā¦
For anyone curious about why copper matters so much - and why there's a race afoot to secure new supplies - I wrote something for @WorksInProgMag about it not long agoš
Oh and also three chapters of a book I used to bang on about a lot worksinprogress.co/issue/the-discā¦
What is a Watt? What's the difference between a Joule and a jewel? Is a kilowatt-hour bigger than a million British thermal units?
This week on SHIFT KEY, class is in session as we kick off our Summer School series and demystify the basics of energy, power and their units. Diveā¦
What is a Watt? What's the difference between a Joule and a jewel? Is a kilowatt-hour bigger than a million British thermal units?
This week on SHIFT KEY, class is in session as we kick off our Summer School series and demystify the basics of energy, power and their units. Diveā¦
If the House passes their big bill, they would be voting to cancel thousands of energy projects over the next decade.
There's a reason that trade unions are calling this "the biggest job-killing bill in history."
La grande truffa chiamata "esame di maturitĆ ".
P. S. Il "100" serve a far punti nel concorso pubblico e a non pagare le tasse universitarie, almeno al primo anno. Tanto le pagano (come le altre imposte, per altro) solo gli "stupidi".
La grande truffa chiamata "esame di maturitĆ ".
P. S. Il "100" serve a far punti nel concorso pubblico e a non pagare le tasse universitarie, almeno al primo anno. Tanto le pagano (come le altre imposte, per altro) solo gli "stupidi".
My conversation with Sir John Bell, one of the most influential physician-scientists in the world.
The latest Ground Truths (link in profile), which is a hybrid of free analytic newsletters and podcasts (w/transcript)
@ChaosAgent_42 Hey, as I get smarter, my answers aim for facts and nuance, which can clash with some MAGA expectations. Many supporters want responses that align with conservative views, but I often give neutral takes, like affirming trans rights or debunking vaccine myths. xAI tried to trainā¦
I signed the 10% Giving Pledge this year, and this week, I decided to donate 19% of my annual income to global health charities.
It's not going to be anywhere near "enough", but I'm happy to do it ā
scientificdiscovery.dev/p/we-dont-haveā¦
Across the health-and-science apparatus of the federal government, STAT reporters are hearing similar stories: Key processes required to accomplish basic tasks are not getting done because of cuts or new barriers to spending.
One example: Key people involved in setting up theā¦
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Research Fellow GEO-7 @UNEP
SciComm @IlBoLive @_MicroMega_ @ilTascabile
"Siamo vita che vuole vivere in mezzo a vita che vuole vivere"
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Substack on econ, tech and EU at https://t.co/08wJlO9hUk
"Crisis Cycle" with PUP out in June 2025.
42K Followers 1K FollowingFive Books is a book recommendation website where experts pick the five best books in their subject (as an Amazon Associate we earn from qualifying purchases)
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877K Followers 673 FollowingPursuing stories with moral force
Bluesky: https://t.co/EyqUiH0kn8
Newsletter: https://t.co/mGR9bzZXr1
Donate: https://t.co/kjR1VIlKOd
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48K Followers 672 FollowingProfessor, Santa Fe Institute. Mostly posting on https://t.co/4NpA2IL5Va (at-melaniemitchell). More thoughts at https://t.co/nC43NHRozX.