During nucleosome passage, Pol II causes loss of H2A-H2B dimers from the nucleosome, resulting in hexasome formation. We provide structural evidence for this process and observe that Pol II backtracks upon encountering nucleosomal barriers @MolecularCell. authors.elsevier.com/c/1fRPa3vVUPK8…

Great work by @MoritzOchmann, @GargGaurika, @seyvos, and @CramerLab ! We provide not only structural data for the mammalian EC*-hexasome complex, but also for EC*-TFIIS and EC-TFIIS complexes, and exciting biochemistry focusing on backtracking and rescue by TFIIS.