Team providing patient-centered care enhanced by innovative clinical trials, translational research, community outreach & education | (617) 726-6500massgeneral.org/cancer-center/… Boston, MAJoined December 2022
#SABCS25 | Wed, Dec 10 at 1PM CST
🔬 Mark your calendars! Dr. Dennis Sgroi @MGBpathology will speak on "HER2 low/ultralow; What the pathologist sees"
🔗 brnw.ch/21wVrwG
#SABCS25 | Wed, Dec 10 at 1PM CST
🔬 Mark your calendars! Dr. Dennis Sgroi @MGBpathology will speak on "HER2 low/ultralow; What the pathologist sees"
🔗 brnw.ch/21wVrwG
Drs. Elena Michaels and Seth Wander @MGHCancerCenter discuss the POLARIS study and other biomarker studies. Such studies:
🔍 Enhance our understanding of the genomic landscape of CDK4/6i resistance
🧬 Reinforce the utility of serial genomic profiling
ascopubs.org/doi/10.1200/PO…
🔬 Dr. Leif Ellisen (@harvardmed) at #DAVABreast:🧪 NeoSTAR trials test sacituzumab govitecan (SG) ± pembrolizumab as neoadjuvant in early TNBC📈 Exploring response-guided strategies beyond anthracyclines✅ pCR in 50% of patients
New insights in 1L PD-L1+ mTNBC: Dr. Leif Ellisen of @harvardmed shares SG+pembro improved PFS over chemo+pembro. Efficacy observed across subgroups, with tolerable safety and promising early OS trends. #DAVABreast
🚨 Hot off the press! Drs. Arielle Medford and Seth Wander @MGHCancerCenter discuss SERENA-6, a paradigm-shifting trial that shows promise for personalized cancer care informed by ctDNA-guided molecular surveillance #BreastCancer#BCSMnature.com/articles/s4157…
CDK4/6i with endocrine therapy are the standard 1st line therapy for HR+ HER2- #MBC. Would you consider switching patients who have been on Palbociclib for HR+ #MBC to Ribociclib or Abemaciclib? Dr. Neelima Vidula @MGHCancerCenter answers this here: dailynews.ascopubs.org/do/cycling-thr…
📰 Dr. Arielle Medford led this genomic & proteomic profiling of GATA3mut in HR+ MBC
-Distinct ctDNA-based genomic landscape
-CPTAC analysis suggests mechanism for sensitivity to MDM2 inhibition
-GATA3mut associated with poorer survival on ET monotherapy
link.springer.com/article/10.100…
National Cancer Survivor's Day is a day to #CelebrateLife and acknowledge the resilience, strength, and courage of those who have been affected by cancer. #NCSD2025
Pictured are some of our patient story participants.
📢 @RachelAbelman unveils results from the NeoSTAR trial at #ASCO25
🔑 4 cycles of pre-op SG+P resulted in a 32% pCR rate in early-stage TNBC
🔑 No new safety signals identified
🔑 50% of patients achieved pCR with a non-anthracycline regimen (SG+P only or with additional NACT)
🚨 June 1 | 8AM CDT | Breast Cancer - Local/Regional/Adjuvant
Don't miss @RachelAbelman@MGHCancerCenter presenting results from the NeoSTAR trial, a phase 2 study of response-guided neoadjuvant sacituzumab govitecan and pembrolizumab in patients with early-stage TNBC! #ASCO25
Building on prior work, Dr. Neelima Vidula & @MGHBreastOnc colleagues describe brain metastases in patients with metastatic #breastcancer & cfDNA somatic BRCA1/2 mutations - cfDNA may help identify patients at higher risk for developing brain metastases ⬇️
link.springer.com/article/10.100…
This study led by Dr. Rupali Sood & Dr. Neelima Vidula evaluates clinical/genomic characteristics, trial participation, and genotype-matched therapy among patients with metastatic #breastcancer - barriers to precision oncology need addressing
@CCR_AACR: aacrjournals.org/clincancerres/…
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