Mancias Lab @ManciasLab
#PancreaticCancer Research Lab interested in selective #autophagy, iron, therapeutic resistance, and #proteomics. @DanaFarber, @BrighamWomens, @harvardmed manciaslab.dana-farber.org Boston, MA Joined May 2017-
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Mancias Lab retweeted
Excited to share our latest story @NatureComms. Here, we used quantitative proteomics, metabolomics and in vitro/in vivo CRISPR screens to define mechanisms of resistance to DHODHi in PDAC and propose combinatorial approaches with BCL-XL inhibitors: nature.com/articles/s4146…
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Mancias Lab retweeted
How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/articl…
Mancias Lab retweeted
During the keynote addresses at #AACRpan24, Eileen M. O’Reilly and Joseph D. Mancias discussed how understanding pancreatic cancer’s strengths can help researchers uncover its weaknesses. Learn more on the #AACRBlog: bit.ly/47G1kQ9 @EileenMOReilly @ManciasLab
Mancias Lab retweeted
Joseph D. Mancias discussed "Targeting Autophagy in Pancreatic Cancer" in a Rising Star Keynote Lecture during the AACR Special Conference on Advances in Pancreatic Cancer Research. #AACRpan24 @ManciasLab
Mancias Lab retweeted
The (almost) full program is now online with an amazing lineup of speakers! #AACRPan24 @EileenMOReilly @ManciasLab @DrJashDatta @TeresaZimmers @DrHendifar @JanowitzTobias @wantong_yao @MaraShermanLab @KenOliveLab @andrewaguirremd @cjder23 @bryant_kl @pratt_ed @mggoggins…
The (almost) full program is now online with an amazing lineup of speakers! #AACRPan24 @EileenMOReilly @ManciasLab @DrJashDatta @TeresaZimmers @DrHendifar @JanowitzTobias @wantong_yao @MaraShermanLab @KenOliveLab @andrewaguirremd @cjder23 @bryant_kl @pratt_ed @mggoggins…
Mancias Lab retweeted
#AACRpan23 @graceah9 presenting her poster today - an awesome collaboration with @ManciasLab
Mancias Lab retweeted
WE ARE HIRING! We are looking for a motivated postdoc to work on a fully-funded project studying the role of iron metabolism in drug resistance in pancreatic cancer. 3 weeks left to apply. Please spread the word. au.dk/om/stillinger/… lnkd.in/eNgDM74z
Mancias Lab retweeted
Our #OpenAccess review on #PancreaticCancer - advances & challenges is now online at @CellCellPress Many thanks to @CJHPhD @Pasca_Lab & @LyssiotisLab for all the hard work & @jiaying_tan6 for the opportunity. It’s FREE to read so share widely! cell.com/cell/fulltext/…
Mancias Lab retweeted
We are so inspired by patients like Candace and her experience. With a loving and supportive family and the latest treatments at @DanaFarber, Candace is a source of hope for more patients with pancreatic cancer. blog.dana-farber.org/insight/2023/0…
Mancias Lab retweeted
Researchers at @DanaFarber and other institutions recently made important discoveries into the recycling system of pancreatic cancer cells, a promising step toward targeted therapies for one of the most challenging cancers. blog.dana-farber.org/insight/2022/1…
Mancias Lab retweeted
Pancreatic cancer cells operate a recycling program that would be the envy of any municipality — but the only beneficiaries are the cells themselves. blog.dana-farber.org/insight/2022/1…
Mancias Lab retweeted
A cross-country collaboration between former Damon Runyon-Rachleff Innovators @rushika_perera and @ManciasLab uncovered another way that #PancreaticCancer evades targeted therapies – and a new potential therapeutic target: bit.ly/3uQwFgd
Mancias Lab retweeted
Latest Wolpin-Nowak lab paper on single cell, in situ protein-based characterization of transcriptional subtypes in pancreatic cancer now out in @CR_AACR aacrjournals.org/cancerres/arti…
Mancias Lab retweeted
Now online in @CD_AACR: Targeting UGCG Overcomes Resistance to Lysosomal #Autophagy Inhibition by Vaibhav Jain, David Speicher, @AmaravadiRavi and colleagues @TheWistar @PennCancer aacrjournals.org/cancerdiscover…
Mancias Lab retweeted
Robert Hale's determination in @DanaFarber and the Hale Family's incredible generosity help drive @DanaFarber_Hale closer to a cure for pancreatic cancer. forbes.com/video/63128816…
Mancias Lab retweeted
On the cover!! Thanks @CD_AACR for featuring work from our lab by Miru Ravichandran and @ManciasLab @SantanaCodina on the cover !
On the cover!! Thanks @CD_AACR for featuring work from our lab by Miru Ravichandran and @ManciasLab @SantanaCodina on the cover !
Mancias Lab retweeted
Thanks to @CD_AACR for featuring our stories @ManciasLab and @rushika_perera on the cover of the September issue!
Thanks to @CD_AACR for featuring our stories @ManciasLab and @rushika_perera on the cover of the September issue!
Mancias Lab retweeted
🚨Job Posting: The @YatrikShahLab & @LyssiotisLab are looking for a postdoc to study the role of iron, O2, & metabolism in erythropoiesis. Opportunities to learn and employ multiple cutting-edge technologies in 2 ~pretty cool labs 😁 DM with interest.
Mancias Lab retweeted
Happy to share our latest work now out in @Nature. At long last, we resolved the structure of the SHOC2-RAS-PP1C complex and integrated this work with deep mutational scanning to comprehensively evaluate #SHOC2 structure and function. 🧵(1/n) nature.com/articles/s4158…
Mancias Lab retweeted
Two recent preclinical studies highlight the importance of ferritinophagy in pancreatic cancer, with elevation of a ferritinophagy expression signature also predicting poor prognosis in patients with PDAC: aacrjournals.org/cancerdiscover… and aacrjournals.org/cancerdiscover… #PancSM
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