Regular coffee consumption is associated with increased brain white matter integrity & cortical thickness.
Conflict of interest: I am drinking my morning coffee
@NTFabiano Tea maybe better? From population study? Conflict of interest- drinking my 6th cup of tea today 😛 nature.com/articles/s4139…
@NTFabiano Regular consumption of Nicholas Fabiano, MD tweets is associated with increased brain white matter integrity & cortical thickness.
Breakdown of the paper: The scientists think that drinking a moderate amount of coffee, like one to four cups a day, might be good for the brain. It seems to make the tiny parts of the white brain matter stronger and the outer layer of the brain thicker. This could be because coffee has special things that fight off bad stuff in the body and help protect the brain. They also noticed that people who drank more coffee were often younger, had more schooling, and had fewer health problems like high blood pressure or sugar sickness. This suggests that coffee might help in many ways, not just directly in the brain. The study also saw that drinking a lot of coffee, like five or more cups, did not show the same good effects, which is like a "U" shape where a little is good, a lot is not as good, and too much might not help at all. ......
@NTFabiano @grok so is it good or bad to drink coffee?
@NTFabiano You trade these for poorer sleeper and more anxiety by the way.
@NTFabiano White matter is just connection. Grey matter is cognition.
@NTFabiano I gave up coffee a month ago, and my sleep and morning mood have improved a lot since then.
@NTFabiano I’m caffeine free for over 3 months and feel so much better. I also would just do a cup a day. So was t a crazy coffee drinker but it would give me negative effects.
Coffee's neuroprotection likely stems from autophagy enhancement and mitochondrial biogenesis - classic damage-clearing mechanisms. White matter integrity preservation suggests myelin maintenance, while cortical thickening implies reduced neuronal attrition. But here's the key: it's treating symptoms, not root causes. Real brain rejuvenation needs targeted lipofuscin clearance and crosslink breaking. Still, I'll take my espresso while we engineer the cure!
@NTFabiano What about red bull? Does it infact give my hippocampus wings?
@NTFabiano Correlation, not causation. Smart people tend to drink more coffee because they have to do stuff.
@NTFabiano I must be a genius by now.
@NTFabiano I apparently don't drink enough coffee to know if this is a good or bad thing.
@NTFabiano tea, coffee, cigarettes, alcohol, they are all meditations, breathing exercises, reset breaks. :)
@NTFabiano Is it coffee or just caffeine?
@NTFabiano now is this a coffee specific effect or generalized among caffeine products, and is this based on an observed increased baseline intake to differentiate between coffee induced effects rather than a co-incidence given the natural urge of the cognitively capable to stack stimulants
@NTFabiano Do amphetamines. Would be interesting to see long term effects of regular Amphetamine use.
@NTFabiano no it isn't why is medicine so fast and loose with the scientific method? you don't have an emergent truth until someone comes along, tries to falsify this, and can't. ppl who make claims based on prelim studies make us all look bad
@NTFabiano is this a coffee plus or minus @grok and what if I use coffee as a carrier for adaptogens like lions main mushrooms or something more healthy that aid in better quality of life?
@NTFabiano This is what I tell myself every morning when I have my cups of coffee
@NTFabiano @grok I’m literally running after a cat, give me the rundown of this tweet
A masterclass in confusing p-values and significance for effect size, if I ever saw one. No correction for multiple testing either. Statistical noise dressed up as findings 🫥 If you’re looking for evidence of neural or cognitive health benefits from coffee, there are better sources.
@NTFabiano I think the central cause of increased cortical thickness is to actually use that neocortex, i.e. do cognitively demanding work. People who do that tend to drink more coffee.
@NTFabiano Anything to cope with my coffee addiction.
@NTFabiano Waiting for the study that says heart attacks have been correlated with those that take a poo