The goal of SSRIs is to disable the inhibitory effect of the 5-HT1A autoreceptor so that more serotonin reaches postsynaptic heteroreceptors. Evidence suggests SSRIs do exactly this, but their long-term impact on 5-HT1A may undermine this effect. Early in SSRI treatment, the 5-HT1A autoreceptor desensitises due to prolonged activation via transporter inhibition. While 5-HT1A receptors can desensitise or sensitise to various stimuli, SSRIs may impose a more enduring effect on these receptors. Long term use of SSRIs appear to also desensitise the post-synaptic 5-HT1A heteroreceptors - especially in genetically vulnerable individuals. This can result in a reduction in activity in the prefrontal cortex - an area of the brain vital for decision making and reward. For references and more, visit: secondlifeguide.com/2024/01/15/ssr…

@PAS_secondlife SSRIs are often prescribed for depression, but their side effects are deeply concerning. How can we justify giving someone struggling with mental health a medication that lists suicidal thoughts as a potential risk? Thanks, VA, for pushing these meds on veterans.