Patricia Yuste @PYusteCheca
Molecular biologist. Postdoc @MPI_Biochem Joined March 2012-
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Structural & functional analysis revealed that the extracellular #chaperone #clusterin functions through two hydrophobic tails in preventing protein aggregation. ❕Publication: nature.com/articles/s4159… ❕Press Release: biochem.mpg.de/structure-of-c… #Alzheimers @NatureSMB @PYusteCheca
New online! Structural analyses define the molecular basis of clusterin chaperone function bit.ly/47kDZ8k
Regulated proteolysis induces aberrant phase transition of biomolecular condensates into aggregates; a protective role for the chaperone Clusterin: sciencedirect.com/science/articl…
Very excited to share the structure and functional characterization of Clusterin, a key extracellular chaperone and apolipoprotein (ApoJ) linked to cancer, cardiovascular pathology and neurodegeneration. biorxiv.org/content/10.110…
Scientists from the Hartl Department show that the protein #Urm1 protects other proteins in cellular stress situations by promoting phase separation. ❕Publication: cell.com/cell/fulltext/… ❕Press release: biochem.mpg.de/urm1-protects-… @CellPressNews
Escucha a José Manuel Moreno (catedrático y miembro @IPCC_CH ) : “Quitar carriles-bici es una ideología de fanáticos y lunáticos que van a causar muertes”. Así, sin pelos en la lengua hoy en el Congreso de los Diputados
I am delighted to announce that my PhD work has finally been published, in which we uncovered a novel role for GCN1 in mitigating translational readthrough. #collision #readthrough #GCN1 @MPI_Biochem sciencedirect.com/science/articl… A thread. 🧵 1/18
A team led by Ulrich Hartl found out that the protein GCN1 helps to secure the "accident site" after two #ribosomes collided and calls other complexes to degrade the defective #mRNA @CellCellPress ❕ press release biochem.mpg.de/can-we-promote… ❕ full article cell.com/cell/fulltext/…
Dr. Paul Janssen, the founder of Janssen pharmaceutica (now J&J), was one of the most prolific drug discovery scientists ever. Between 1953-1991 Janssen and his team discovered >70 new medicines. I enjoyed this paper about his R&D philosophy: onlinelibrary.wiley.com/doi/abs/10.111…
At ADPD 2023, scientists showed that biosensor cell lines that detect tau seeds do make tau fibrils. A chaperone tears them apart. Does this happen in the #alzheimersdisease brain? @adpdnet @utswnews @MPI_Biochem @MRC_LMB ow.ly/4yyr50NEGeq
Joint Statement from German Postdoctoral Networks on the Eckpunktepapier from the BMBF postdocnet.mpg.de/127851/Stateme… with @MunichPostdoc @LeibnizPostDocs @Health_talents @FMP_MDC_PDA @PAW_Germany @SociedadCerfa @RedeApoena @awi_postdocteam and more. #WissZeitVG #ichbinhanna
Join us for a PhD in the Protein Biogenesis lab @TheCrick ! We have a very exciting project aimed at understanding how human cells orchestrate the folding of different proteins at the ribosome. crick.ac.uk/careers-study/…
The final version of our manuscript is now online: nature.com/articles/s4146… Thanks so much to @Itikasaha and all our friends and collaborators that were part of this journey @ruferbus @IrinaDudanova @DavidWSanders2 @PYusteCheca
Check out our latest review about the diverse functions of the extracellular chaperone Clusterin in the pathogenesis of neurodegenerative diseases doi.org/10.1002/bies.2…
Hoy la precariedad de los postdocs tiene un altavoz en @elpais_espana gracias a @ElisaSilio . @CienciaGob , @UniversidadGob , es necesario actuar YA. @FJIprecarios @CientificoenEsp @postdoc_es elpais.com/educacion/univ…

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