Phyre2 @Phyre2server

News and updates from the developer of the protein structure prediction server Phyre2. sbg.bio.ic.ac.uk/phyre2 Imperial College London, UK Joined August 2010

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Phyre2 @Phyre2server

7 months ago

Please note new citation - "Phyre2.2: A Community Resource for Template-based Protein Structure Prediction" Powell HR et al. Journal of Molecular Biology (2025) in press DOI: doi.org/10.1016/j.jmb.…

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Phyre2 @Phyre2server

10 months ago

We had an internal network issue at around 5pm GMT, so some jobs failed then - apologies!

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Our main machine used for starting Phyre jobs on our cluster has died (this one sits between the web-server and the cluster nodes); currently installing a replacement machine but probably no service until tomorrow (Wednesday 6th November).

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Phyre2 @Phyre2server

10 months ago

It seems that the extra security offered by https will have to wait until one of our gurus is in the building next week...

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Phyre2 @Phyre2server

10 months ago

We are trying to move our site from the old and insecure "HTTP" protocol to "HTTPS" today - so the server will be up and down like a yo-yo until the work is complete.

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Phyre2 @Phyre2server

a year ago

Jobs are failing for an unknown reason - maybe some hardware is about to die. Patience (and re-submission of non-batch jobs) is your friend here. For batches, please contact me by e-mail so I can try to rescue the failed jobs.

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Phyre2 @Phyre2server

2 years ago

We are buying a new server rather than just upgrading the OS on the current one - so we will not be turning it off this weekend. Feel free to continue submitting jobs...

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Phyre2 @Phyre2server

2 years ago

Phyre2 unavailable 1st - 4th December 2023 - server upgrade. Please don't submit big batch jobs after Thursday 30th November until Monday 4th November.

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Phyre2 @Phyre2server

2 years ago

Hi folks Sorry about this - I broke the "job description" feature in Phyre2 a couple of days ago, so any jobs will have had some kind of undefined description. If you want a useful description for your job, running the same job now should give the expected output.

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Phyre2 @Phyre2server

2 years ago

Hi folks We were wondering - in the era of AlphaFold, what are people using Phyre2 for? What features are most useful?

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Phyre2 @Phyre2server

3 years ago

Sorry folks - we've had a very high load over the last few days (partly due to a software update error) so I've had to stop job submissions a couple of times. We should be back to normal in the next hour or so.

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Phyre2 @Phyre2server

4 years ago

The *good* news is that I'm making progress in installing our new nodes and getting everything running on them - so sometime in the next few weeks we should have more reliable hardware and fewer crashes.