🇳🇵मानार्थ राजा @Prthakulla
Kathmandu, Nepal Joined April 2013-
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🎗️ Nobel Prize 2025: When immune tolerance met tumor escape! Mary Brunkow, Fred Ramsdell & Shimon Sakaguchi win for discovering regulatory T cells (Tregs) - the body’s immune “brakes.” 🔬 In oncology, these same brakes often shield tumors from immune attack. Their discovery…
The Future of Type 1 Diabetes Therapy (Lancet 2025) 🔑 1. New Paradigm in T1D Insulin discovery a century ago was revolutionary, but life expectancy and complication risks remain reduced in T1D. Now, T1D is being reframed as an immune-mediated disease with opportunities for…
🦴 #Glucocorticoid-induced #osteoporosis (GIOP): • 📉 Early bone loss via osteoblast/osteocyte suppression • ⚠️ #FRAX often underestimates risk • 💊 #Denosumab & #teriparatide >#bisphosphonates • 🧮 Treat from GC start 🔗 doi.org/10.1016/S2213-… @TheLancetEndo #EndoTwitter
Two Reviews @NEJM Twenty years apart Two great colleagues Bob Kyle and Shaji Kumar
A diagnostic and treatment algorithm for Malignancy of unknown origin, also known as cancer of unknown primary (CUP). nature.com/articles/s4157…
🔺 Listeriosis (Nature 2025) doi.org/10.1038/s41572…
This JAMA Insights explores the management of severe refractory #asthma, including medications, access to specialists, and managing environmental triggers. ja.ma/46VExjl
✅ Editor's Choice: This review on ulcerative colitis summarizes its epidemiology, pathophysiology, clinical presentation, diagnosis, and management. 💾 Save it for your bibliography: ja.ma/3IUJ0L5
Early-onset gastrointestinal cancer is currently the most rapidly increasing early-onset cancer in the US. This JAMA Patient Page describes early-onset GI cancer and its risk factors, signs and symptoms, management, prognosis, and prevention measures. ja.ma/4gT5V69
Just out in the New England Journal of Medicine! Our comprehensive Review on MGUS: Monoclonal Gammopathy of Undetermined Significance @NEJM nejm.org/doi/full/10.10… 5% of people over age 50 have MGUS. Every physician needs to know and understand MGUS. Lots of Tables and…
🧩 SACQ Lupus (Serologically Active, Clinically Quiescent) 🔬 Definition 🧪 ↑anti-dsDNA, ↓C3/C4 ⏳ No clinical activity ≥2 yrs 📊 Prevalence 👥 ~6–15% of SLE pts 📈 Natural history 🌿 Many remain quiescent for yrs ⚡ Some flare (risk: young, ↑dsDNA, male, persistently…
Clinicians can enhance patient understanding by using numerical data instead of verbal probabilities, consistent denominators, absolute risk comparisons, and clear context for unfamiliar data types. ja.ma/42JRNGk
Clinicians can enhance patient understanding by using numerical data instead of verbal probabilities, consistent denominators, absolute risk comparisons, and clear context for unfamiliar data types. ja.ma/4gJCCD6
Corticosteroids in septic shock: a double-edged sword DOI:10.1097/MCC.0000000000001297
🌟TYPE 5 DIABETES MELLITUS During a consensus meeting in Vellore, India, in January, 2025, type 5 diabetes was proposed as the nomenclature for this distinct form of diabetes, subsequently formalised at the International Diabetes Federation (IDF) World Diabetes Congress in…
Delta Ratio Interpretation in ABG In pure HAGMA → rise in AG ≈ fall in HCO₃⁻ → delta ratio ~ 1 (0.8–2.0). If fall in HCO₃⁻ > rise in AG → extra bicarbonate loss → HAGMA + NAGMA → delta ratio <0.8 (esp. <0.4 if dominant NAGMA). If fall in HCO₃⁻ < rise in AG →…
🔺State-of-the-Art Review: Hepatitis C (August 2025 edition) doi.org/10.1093/cid/ci…
Type 2 #diabetes #subtypes classification: a global reckoning with #heterogeneity thelancet.com/journals/landi… #T2D #FREE to read with registration (also FREE) #EASD2025
Pulmonary Hypertension in Valvular Disease: Mechanisms and Pathophysiology of PH in Patients With VHD. jacc.org/doi/10.1016/j.…
#Hypothyroidism is a condition characterized by the insufficient production of thyroid hormones. This Review summarizes the epidemiology, pathophysiology, clinical presentation, and treatment of primary overt hypothyroidism in nonpregnant adults. ja.ma/3VfueRS

Michelle @Michell45850411
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𝓑 @iBikalpa
636 Followers 356 Following शिरो वहति पुष्पाणि गन्धं जानाति नासिका। पठन्ति वेदशास्त्राणि दुर्लभो भावबोधकः॥ | सत् पुरूष उपासक | Disciple of Sant RampalJi
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Atul Koirala, Eng #AU... @atulkoirala
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Aaaaa @Aaaaa00481938
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Dr.Mukesh , MD , DM @dr_immuno29
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Dr Aditya Gudheniya @Gastronaut___
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The Lancet Diabetes &... @TheLancetEndo
53K Followers 2K Following Your leading source of international, cutting-edge research, review, and opinion in clinical diabetes and endocrinology. IF=41·8.
Pradip Bhattarai @realpbhattarai
146K Followers 11K Following न सत्तापक्ष न प्रतिपक्ष मात्र सत्यको पक्षमा हिडने साधारण मान्छे मात्र !
CORE IM @COREIMpodcast
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Keith Siau @drkeithsiau
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NephSIM @Neph_SIM
15K Followers 1K Following A free, mobile-optimized #nephrology teaching tool using CBL & more |#FOAMed #MedEd |@ssfarouk @ISMMSKidney @RachelHilburg @PennKidney | @ASNKidney 2018 IKEC🏅
Dr_Venkey @venkey_97
790 Followers 1K Following 🩺 Junior Resident | Institute of Internal Medicine | Madras Medical College & Rajiv Gandhi Government General Hospital | 🕵Forever curious in Medical Science
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14K Followers 154 Following Professor, Pathology, Mayo Clinic, MN. 💯 clinical. Renal pathology. Use X to teach, clinical info changed=protect confidentiality. Love dogs. Views are my own.
Madhav Sapkota 'Subod... @Subodhsindhu1
392 Followers 230 Following सिन्धुपाल्चोक क्षेत्र नं १ बाट संघीय संसद, प्रतिनिधि सभा सदस्य ।
NDT @NDTsocial
18K Followers 6 Following Nephrology Dialysis Transplantation (NDT) is the leading nephrology journal in Europe. NDT is an official journal of @ERAkidney. Published by @OxfordJournals
Aravind Palraj @Rheumat_Aravind
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Mithu Maheswaranathan... @MithuRheum
8K Followers 843 Following Rheumatologist at Duke 🧑🏽💻💉🏥 | Creator of Rheum OnePagers | Infographics • Lupus • Health Literacy | Tweets are my own.
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5K Followers 3K Following Human, Dreamer, Wanderer MD Resident at TUTH Past President @NRDA_Nepal
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Annals of Int Med @AnnalsofIM
72K Followers 3K Following Annals publishes content to inform medical professionals and society, advance standards of medical research, and improve the health of people worldwide.
JAMA @JAMA_current
488K Followers 686 Following JAMA is an international peer-reviewed general medical journal published weekly online and in print, and a member of the @JAMANetwork family of journals.
The Lancet @TheLancet
735K Followers 463 Following Welcome to The Lancet, one of the world’s leading medical journals, published weekly since 1823.
NEJM Evidence @NEJMEvidence
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NEJM AI @NEJM_AI
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NEJM @NEJM
936K Followers 429 Following The New England Journal of Medicine is the world’s leading medical journal and website.
Bharati Rayamajhi🇳... @iambharati21
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𝓑 @iBikalpa
637 Followers 356 Following शिरो वहति पुष्पाणि गन्धं जानाति नासिका। पठन्ति वेदशास्त्राणि दुर्लभो भावबोधकः॥ | सत् पुरूष उपासक | Disciple of Sant RampalJi
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Amitriptyline, RPh, R... @amitriptyline_8
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आशिष कड�... @kadariya_ashish
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