Pruneda Lab @PrunedaLab
collectively ran by the Pruneda lab, MMI, Oregon Health & Science University @ohsummi | our views are our own ohsu.edu/school-of-medi… Portland, Oregon Joined September 2019-
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Great talk by Rachel Lacoursiere from @PrunedaLab regarding bacterial enzymes to understand non canonical ubiquitination #EMBOubiquitin24
Excited to share this work from former @PrunedaLab superstar @camgroberts! Cam tackled the challenge of identifying #ubiquitin regulators secreted by pathogenic bacteria, and found an entirely new type of E3 ligase that regulates P. aeruginosa virulence! biorxiv.org/content/10.110…
Fantastic to have @jnpruneda @PrunedaLab from @OHSUSOM visiting giving a seminar on his team’s exciting work on how pathogenic bacteria use nifty effector proteins to hijack the ubiquitin system and avoid the host response. Real pleasure to have you at @DTUbioengineer, Jonathan.
As #RareDiseaseDay rapidly approaches, please consider contributing to our collaboration with @RaidenScience to study a rare pediatric disorder.
As #RareDiseaseDay rapidly approaches, please consider contributing to our collaboration with @RaidenScience to study a rare pediatric disorder.
Please consider supporting @RaidenScience! We’re determined to find a way to help children afflicted with this rare #ubiquitin-related disease.
Please consider supporting @RaidenScience! We’re determined to find a way to help children afflicted with this rare #ubiquitin-related disease.
Pleased to share the final version of this work on UBA5, available at @eLife. doi.org/10.7554/eLife.…
Pleased to share the final version of this work on UBA5, available at @eLife. doi.org/10.7554/eLife.…
Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work! sciencedirect.com/science/articl…
Excited to share the final product of this work, now available at @MolecularCell. Extremely proud of @tylergfranklin for this and many other achievements during his thesis work! sciencedirect.com/science/articl…
Great job @tylergfranklin!
New preprint identifying shared and distinct mechanisms of inactivation of the #ubiquitin E1 enzyme #UBA1 across different diseases #VEXAS #SMA #lungcancer doi.org/10.1101/2023.1… Thanks to David Beck @nyulangone, @kyliejwalters and all contributors for a great collaboration!
Excited to share our new review on bacterial effectors that follow or break the "rules" of #ubiquitin signaling. Always a pleasure to work with @camgroberts and @tylergfranklin! embopress.org/doi/abs/10.152…
Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Bacteria can counter noncanonical lipid ubiquitination with a #ubiquitin esterase! Fantastic collaboration with @ThurstonLab and @CMBI_Szczesna, with @r_lacoursiere driving our side of the project using some amazing tools built by the Geurink lab.
Excited to share our preprint on how a cytosolic bacteria evades LPS ubiquitylation and antibacterial autophagy through an effector with esterase activity. Led by @CMBI_Szczesna in the lab @ImperialInfect @CBRB_Imperial with superb collaborator @jnpruneda researchsquare.com/article/rs-298…
What can bacteria teach us about #ubiquitin? A lot! In our latest preprint, @tylergfranklin set out to understand how secreted bacterial ligases catalyze ubiquitin modifications during infection. What he found will surprise you! biorxiv.org/content/10.110…
Happy to share that this work is now online in its peer-reviewed form at @MolecularCell. Huge thanks to our peer reviewers for challenging us, and to my co-authors for rising to meet this challenge. Check out the final product! sciencedirect.com/science/articl…
Happy to share that this work is now online in its peer-reviewed form at @MolecularCell. Huge thanks to our peer reviewers for challenging us, and to my co-authors for rising to meet this challenge. Check out the final product! sciencedirect.com/science/articl…
Great job Tyler!
I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that targets host Lys6-linked #ubiquitin signals with extreme precision. biorxiv.org/content/10.110…
Proud to 🚀 the #RaidenScienceFoundation including Nobel Laureate Dr. Ciechanovar, @UMassChan @PrunedaLab @StJude and @BCMFromtheLabs ..who will together develop a treatment for #UBA5, an ultra-rare neurodegenerative disease. raidenscience.org
Congratulations @camgroberts!
Ever tried to give a 3-minute research presentation? It isn't easy! @PrunedaLab member @camgroberts gave a fantastic flash talk at #UKcellmicro2021 this week and even won a prize! Congratulations to Cam and thank you to the organizers for such a great meeting!
Of course Justine did a fantastic job, we were never DUBious! So proud of @justinevnguyen!
Of course Justine did a fantastic job, we were never DUBious! So proud of @justinevnguyen!

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