Mach Lab @RHMachLab
Laboratory of Robert H Mach med.upenn.edu/apps/faculty/i… University of Pennsylvania Joined April 2020-
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Exciting work from our lab on computer-aided drug design for radio-tracer development titled “Computational Chemistry for the Identification of Lead Compounds for Radiotracer Development” has been recently published in Pharmaceuticals mdpi.com/1424-8247/16/2…
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Mach lab and friends at the @UofPenn game! @AladdinBro @TaraTaghvaee @GuilongT @ChemistryGrEEK @RickBarrett_PhD @air_sea_sam
Mach Lab retweeted
Poly (ADP-ribose) (PAR) is reported to interact with phosphorylated α-Synuclein in post mortem #Parkinsons samples - from @RHMachLab & colleagues; Interactions between negatively charged PAR & lysine residues on the N-terminal region of αSyn confirmed frontiersin.org/articles/10.33…
Mach Lab retweeted
New evaluation of a low-toxicity PARP inhibitors as a neuroprotective agents for #Parkinsons from @RHMachLab; The ideal PARP inhibitor needs to inhibit PARP-1 hyperactivity while also limiting downstream DNA damage & cellular toxicity (ideal for oncology) link.springer.com/article/10.100…
Mach Lab retweeted
Just realized our friends from @RHMachLab at @PennRadiology are on the Twitter! Show them some love!
Mach Lab retweeted
Proof-of-concept study demonstrates new approach for identifying #PET tracers for Parkinson’s & other neurodegenerative diseases🧠 ft Virginia Lee (@PennPathLabMed), @RHMachLab, Zsofia Lengyel-Zhand (@PennRadiology), @EJPLab & John Ferrie (@PennChemistry) bit.ly/33MngIT
Mach Lab retweeted
Our review @RHMachLab @WindhorstBert featured by @Molecules_MDPI !
Our review @RHMachLab @WindhorstBert featured by @Molecules_MDPI !
Mach Lab retweeted
Check out our recently accepted manuscript 📝 in @ChemCommun Synthesis and Characterization of High Affinity Fluorogenic α-Synuclein Probes 🔗 pubs.rsc.org/en/content/art…
Mach Lab retweeted
The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates biorxiv.org/cgi/content/sh… #bioRxiv
Mach Lab retweeted
The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor complex are responsible for the cellular uptake of Aβ42 and its protein aggregates biorxiv.org/cgi/content/sh… #biorxiv_neursci
PARP-1 tracer demonstrates that PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.altmetric.com/details/799318…
RT @PennRadiology PARP-1 tracer demonstrates that PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.altmetric.com/details/799318…
RT @PennRadiology PARP-1 tracer demonstrates that PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.altmetric.com/details/799318…
Mach Lab retweeted
Great @PennMedicine team effort on clinical trial shows PARP-1 expression is independent of breast cancer subtype providing foundational evidence to test PARP PET as a companion diagnostic for PARP inhibitor therapy jamanetwork.com/journals/jamao… #PARP1 #breastcancer @PennMDForum
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