Ray @Real_Yuan24
Health research methods, health economics, health technology assessment, patient values and preferences, epidemiology. Show me the evidence 🌈 📚 Hamilton, Ontario Joined September 2012-
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I am not part of the review team, but NOS is a reasonable candidate for assessing QUANTITATIVE, non-randomized studies such as cohort studies, pre-post studies. They originally planned to use a tool for mixed methodology — which arguably does not work well here.
I am not part of the review team, but NOS is a reasonable candidate for assessing QUANTITATIVE, non-randomized studies such as cohort studies, pre-post studies. They originally planned to use a tool for mixed methodology — which arguably does not work well here.
Even if Cass review were to stick to the original scale, the studies would still “not be high quality”. It is not ideal situation that systematic review authors make changes to their method, but reasonable people would agree we should not kill reviews because of plan changes.
Even if Cass review were to stick to the original scale, the studies would still “not be high quality”. It is not ideal situation that systematic review authors make changes to their method, but reasonable people would agree we should not kill reviews because of plan changes.
A reasonable peer reviewer would not reject results because the systematic review authors changed a scale. Instead, he or she would ask: what is your rationale of changing the scale, is the change justified? What is the impact of changing? So tell me what is the problem?
A reasonable peer reviewer would not reject results because the systematic review authors changed a scale. Instead, he or she would ask: what is your rationale of changing the scale, is the change justified? What is the impact of changing? So tell me what is the problem?
Medical decision analysis can be challenging to understand and apply in clinical practice or systems decision-making. This recent Users’ Guide does a great job of explaining decision analysis and guiding its practical use. pubmed.ncbi.nlm.nih.gov/34226025/
Considering patient and public values and preferences is a crucial part of every clinical practice guideline. Guideline panels should search relevant evidence. GRADE summary of findings tables enhanced understanding of values and preferences evidence. jclinepi.com/article/S0895-…
EBM should be simple, and beautiful
Listening to evidence (what 🇬🇧 doing with the Cass review) or listening to experts (what CBC journalists doing) Could be different!
Listening to evidence (what 🇬🇧 doing with the Cass review) or listening to experts (what CBC journalists doing) Could be different!
They did not bother to read the report before criticizing it
In these critiques of the quality of the 53 studies analyzed, the review authors point to key areas where future researchers could improve the quality of studies. For example, the finding that most studies weren't controlling for key important variables, like pubertal stage.
The systematic lit reviews of pediatric gender-transition treatment that have used the GRADE system to assess the quality of studies findings have all found that they are no better than low quality and are often very low quality, yielding inconsistent, unclear conclusions about…
@ThomasAgoritsas Then I think professionals should acknowledge the value of the Cass review, and use this report as a useful starting point for consensus, or resource for shared decision making, rather than attacking it or ignoring it? @jack_turban
If health professionals providing gender affirming care have been doing “shared decision making”, they must have admitted and informed children and families that the evidence is poor (like the Cass review has found). Have they done so? Or are they busy attacking the Cass review?
If health professionals providing gender affirming care have been doing “shared decision making”, they must have admitted and informed children and families that the evidence is poor (like the Cass review has found). Have they done so? Or are they busy attacking the Cass review?
If medical professionals were to avoid awful medical scandals, we need to self regulate. And the first step is to admit mistakes. Overtreatment in children and adolescents’ development is a mistake. Gender medicine for left is ivermectin for right. Be brave and admit wrongdoings.
If medical professionals were to avoid awful medical scandals, we need to self regulate. And the first step is to admit mistakes. Overtreatment in children and adolescents’ development is a mistake. Gender medicine for left is ivermectin for right. Be brave and admit wrongdoings.
Critics of the methodology of the systematic reviews that form the basis of the Cass Review are displaying their limited understanding of research methods and evidence based medicine — but that’s what got us into this mess in the first place
"The evidence base for interventions in gender medicine is threadbare, whichever research question you wish to consider—from social transition to hormone treatment." -@bmj_latest EDITOR IN CHIEF @KamranAbbasi
Adolescent girls have been the most impacted by the "gender-affirming care" scandal. #CassReview
Gordon H. Guyatt @GuyattGH
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20K Followers 842 Following Canada’s leading academic, ambulatory hospital & world leader in the health of women. Account monitored by Communications, weekdays, 9am-5pm.CANADA: Alberta Premier Danielle Smith [@ABDanielleSmith] says that the United Kingdom’s recently published #CassReport will inform the development of her government’s transgender policies. @ZivoAdam in @nationalpost nationalpost.com/opinion/daniel…
The Cass Review is, itself, peer review. An experienced, unbiased, highly-qualified specialist reviewed the evidence for transitioning children, and concluded that experimental treatments have been given without a solid evidence base. Here's a crazy idea. Why not read it?
Onset of the COVID-19 pandemic impacted ongoing clinical trials, especially in critical care settings. Take a look at our recent article examining these effects in the global REVISE trial. From consenting procedures to development of a COVID substudy link.springer.com/10.1186/s12874…
Applying GRADE-CERQual to Interpretive Review Findings: Reflections From a M-E journals.sagepub.com/doi/pdf/10.117…
When the alternative of treatment is not certain death, and when the person facing potential treatment is a child who cannot consent, and when that child faces potentially losing their fertility and sexual function from treatment, this raises the demands for strong evidence.
Rapid reviews methods series: assessing the appropriateness of conducting a rapid review Research methods and reporting by @CGarritty @decdevane et al. @CochraneRRMG #OpenAccess Link: bit.ly/4axTmsR
My latest interview about EBM with a very astute and insightful and outside-the-box interviewer, Domhnall MacAuley. medicsvoices.com/gordon-guyatt-…
Pretending we don’t possess the biological characteristics that lead to women’s oppression doesn’t resolve the oppression. It makes it impossible to analyse or challenge the basis on which women are oppressed. 1/3
Excessive use of words like ‘commendable’ and ‘meticulous’ suggests ChatGPT has been used in thousands of scientific studies “It seems thousands of researchers are suddenly ‘delving’”😅 english.elpais.com/science-tech/2… via @elpaisinenglish
Medical decision analysis can be challenging to understand and apply in clinical practice or systems decision-making. This recent Users’ Guide does a great job of explaining decision analysis and guiding its practical use. pubmed.ncbi.nlm.nih.gov/34226025/
Struggling to interpret the discrimination of #prognostic models? 🤔 Our new #GRADE paper demystifies whether an AUC of 0.7 is just right, or not enough. Discover how to assess model accuracy with confidence! 📊🔍 sciencedirect.com/science/articl… @GuyattGH @AlfonsoIorio @Richard_D_Riley
Considering patient and public values and preferences is a crucial part of every clinical practice guideline. Guideline panels should search relevant evidence. GRADE summary of findings tables enhanced understanding of values and preferences evidence. jclinepi.com/article/S0895-…
📡On the spotlight: The man behind “Evidence-Based Medicine”…and so much more (with @GuyattGH, @GRADE_WG). See the full interview at: medicsvoices.com/gordon-guyatt-…
Without YuTian my first two Cochrane reviews would not have been possible. I’m glad he is still engaged with Cochrane! @CochraneUrology @EBMUrology
Congratulations to the distinguished Gordon Guyatt (@GuyattGH) on being awarded the prestigious Henry G. Friesen International Prize in Health Research. @HEI_mcmaster @friendsofcihr ow.ly/tUSH50RgAG6
Our paper 'Leveraging generative AI for clinical evidence synthesis needs to ensure trustworthiness' has been published by @JBI_Journal. A great collaboration between WCM, Columbia, Northeastern, UPenn, Pitts, Vanderbilt, Uni of Haifa, and NIH/NLM! tinyurl.com/3d595fcx
1/ The Cass Review explains, in detail, why we need to trust systematic reviews over both doctors' anecdotal evidence and low-quality standards published by professional associations. The CBC responds by publishing an article that cites professional associations and is dominated…
In 2018, Stonewall literally told schools to shred a research pack saying there were risks to puberty blockers. "We, in the strongest possible terms, denounce and condemn this publication. If it lands on your desk, do the right thing: shred it.” 1/3 thetimes.co.uk/article/stonew…
Dr. Angela Goepferd (@DrGoepferd) of Children’s Minnesota says that “studies show” that adolescents have better mental health outcomes if they are socially transitioned. A new systematic review of social transition published in the British Medical Journal finds, however, that…
"For the medical profession as a whole, there is much to reflect on: 𝗵𝗼𝘄 𝗱𝗶𝗱 𝘁𝗵𝗲𝘆 𝗹𝗼𝗼𝗸 𝘁𝗵𝗲 𝗼𝘁𝗵𝗲𝗿 𝘄𝗮𝘆 𝗮𝘀 𝘁𝗵𝗶𝘀 𝘁𝗿𝗮𝘃𝗲𝘀𝘁𝘆 𝘂𝗻𝗳𝗼𝗹𝗱𝗲𝗱?" READ @ObserverUK on #CassReview: theguardian.com/commentisfree/…