Rheumatology Pearls @RheumPearls
Rheumatology focused educational pearls in 140 characters or less! rheumpearls.com Christopher Collins MD Joined March 2011-
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Post-infectious #Lyme #arthritis ➡️Persistent #synovitis that worsen post-antibiotic ➡️Excessive dysregulated pro-inflammatory immune response ▶️Exceptionally high amounts IFNγ ▶️Inadequate anti-inflammatory cytokine IL-10 👉🏽nature.com/articles/s4158… via @NatRevRheumatol
Turn in on March 2nd to hear me talk about our efforts to treat lupus nephritis.
The @NephJC team is going to be discussing the Belimumab in #LupusNephritis (BLISS LN) for #NephJC on Nov 24/25 #RheumJC
People here don’t mind following guidelines. That’s pretty much it. No complaints about personal loss of freedoms or politicization of mask wearing. #rheumjc
Hi. Chris Collins here in Denmark. Jet lagged and can’t sleep. #rheumjc
Next #RheumJC will be Thursday, June 25th Topic: Data from the COVID-19 Global Rheumatology Alliance Physician-Reported Registry More info: rheumjc.com/2020/06/data-f… Summary from @HealioRheum: healio.com/news/rheumatol…
A book on immunology. One of our faculty use thins one... amazon.com/gp/aw/d/111954…
A book on immunology. One of our faculty use thins one... amazon.com/gp/aw/d/111954…
Thanks for participating tonight.... sorry to sound like a commercial, but I do like to test. It's helped my group in several instances. DM me if you have an specific questions. #rheumjc
the test gets you not only the SLE "likelihood ratio" but also also a ton of other antibodies like APLs, RA specific antibodies, thyroid antibodies (as a know cause of ANA positivity), anti-C1Q (renal SLE predictor) and others. #rheumjc
The out of pocket cost for the test (currently) is max $45 for the patient. My understanding is that the company tries to get reimbursed from insurance (most of the time success, but sometimes no) but will only bill patient $45 and write off any losses #rheumjc
The AVISE test came back positive for SLE and helped us with deciding which meds were best for her. #rheumjc
And we use it in those patients in whom we just aren't sure what the hell is going on... I recently had a patient with only positive nucolear pattern ANA, Raynaud's, serositis, and pan-cytopenia. Was this scleroderma or SLE?#rheumjc
We user this test fairly regularly in my clinic... 1) because this is a dedicated immunology focused lab so quality control for tests like ANA and dsDNA are trusted (so many false negs and positives out there in commercial assays) #rheumjc
anyone else want to ask me about this study or the CB-CAPs (cell-bound complement activated products) technology? #rheumjc
we did another study where we looked at ANA positive fibro patients.... and none of them tested positive for lupus using the AVISE test... none. Very helpful in keeping these patients off meds like steroids and HCQ. #rheumjc
At the end of the day, this is but one more tool in the diagnostic algorithm. A piece of the puzzle so to speak. Clinicians still make the diagnosis of lupus based on all available information. This test just adds to it. Sometimes very helpful, other times not needed. #rheumjc
While dsDNA has a very high specificity for SLE, the sensitivity is terrible. Complement split products like C4d on the other hand have both good specificity as well as sensitivity and out perform dsDNA, C3, C4, and ANA as biomarkers for SLE #rheumjc
The question of "is it ready for general use?"... probably. It's a comprehensive assay of different lupus and other CTD related antibodies which collectively generate a "score" for likelihood ratio for SLE. #rheumjc
Dr. John Cush @RheumNow
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Cheers, mate! Annual DC Rheum lecture series begins tonight with Australia's star rheumatologist @philipcrobinson speaking about #COVID19 data provided by rheums & patients worldwide, led by researchers seen here:
@BolekBerqui The registry likely biases towards more severe cases (more likely to be noted/reported) #RheumJC
@RheumJC Unfortunately, most rheumatologists have normalized supratherapeutic doses of PDN as being OK. This makes @EricFMorand squirm at night...
Anyway, table 1 shows the demographics of the first 600 patients in the provider-entered registries. See image... lots of data to look at.... you might have to zoom in #RheumJC
@RheumJC @WUSTLmed @alhkim Yes!! Big fan! I actually just recently had the opportunity to work w/ him on a review of COVID-19 and complement, which was awesome! AND when I had acute tendinitis in my supraspinatus muscle, he injected it with steroids and gave me use of my arm back, so like I said, big fan!
@RheumPearls Wait... people... follow... guidelines??? #RheumJC
Next #RheumJC will be Thursday, June 25th Topic: Data from the COVID-19 Global Rheumatology Alliance Physician-Reported Registry More info: rheumjc.com/2020/06/data-f… Summary from @HealioRheum: healio.com/news/rheumatol…
This is what #GWRheum look like making rounds @GWHospital during #COVIDー19
@RheumPearls @DavidLeverenz @Nephro_Sparks @EBRheum @jeffsparks @alhkim @rheum_cat @psufka @RheumResearch @LisaCriscione Okay I have watched the #NephMadness video and I understand now. It sounds AWESOME 🤩
#GWRheum is looking forwards to the launch of the COVID19 Global Rheumatology Registry tomorrow. Follow @rheum_covid for the latest updates on global responses to COVID19. We are proud that @KilianMD is leading the efforts for our team.
@WLASZ Congratulations on this unique work. Such a long, multicenter study needs dedicated people and this you are. Be proud of this important clinical result that shall benefit many patients in the future.
As a Rheumatologist that spends 95% of my work time in clinical practice, I love clinical rheum literature. I am so excited to tweet on behalf of Seminars in Arthritis and Rheumatism @seminarthrheum . Follow for great clinical updates.
@cwrightmd Rheum secrets really is an amazing book for our field.
@Tiff_Caza @RheumPearls I've never personally ordered the complement split products -- but after @RheumPearls awesome explanation, I could think of occasions that I might want to. #RheumJC
@RheumPearls Interesting how this adds a bit to our understanding of the early pathophysiology of lupus as well. #RheumJC
Looks like a good one for #rheumJC ? @psufka
Original Article: Trial of Anifrolumab in Active Systemic Lupus Erythematosus nej.md/2LZIwmj
@RheumJC @RheumPearls It’s an honor having worked since the early days with such great people in the @RheumJC development group during these 5 years. Thanks @psufka @RheumPearls @DrBhana @rheumed @hausmannMD @isa75012
@RheumPearls I've seen this used in pts who couldn't tolerate rituximab infusions -- seemed to work. Hard to get approved, obviously. #RheumJC
Shubharthi from Bangladesh. No COI. #RheumJC