Ependymoma, the third most common childhood brain tumor, has seen little therapeutic progress in 30+ years. New findings reveal how the ZFTA–RELA fusion protein drives tumor formation via condensates. ow.ly/fg4r50WMPZJ
The Mack lab congratulates Amelia Hancock, a student from the @UniofBath exchange program, for her fantastic presentation on the work conducted during her year-long rotation. She has been an awesome part of the lab and will be greatly missed!
Dr. Stephen Mack, Associate Member of DNB & CENOS, is presenting “Deciphering the molecular and cellular basis of fusion driven ependymoma to uncover novel therapies” for the virtual Science of Childhood Cancer Lecture Aug 21. stjude.org/socc
We are excited to kick off this season of SOCC with a milestone: our 150th lecture. Join us every Thursday, from 8/14 to 11/20, at 12 PM CT / 1 PM ET for an engaging and interactive 15-week virtual lecture series.
The Baker lab had a fantastic experience mentoring POE intern Ethan Wunibald through the summer. He did an excellent job learning an array of techniques in the lab and presenting his findings. We look forward to seeing what he accomplishes next!
The Northcott lab is proud of High School Research Immersion Program student Catherine Carney for her summer research project poster. Your hard work and boundless curiosity was clear in your findings and way you answered tough questions. We know you have a bright future ahead!
A recent study testing CAR-T immunotherapy for ependymoma identified treatment promise and new questions to understand how the immune response can influence treatment response: stjude.org/research/progr…
A deeper understanding of how cells organize themselves is changing the way we think about neurological diseases. At St. Jude, researchers are studying biomolecular condensates—droplets that organize proteins, RNA and DNA—to uncover new treatment strategies.
Congratulations to the Northcott team making the cover of Cancer Cell for their work demonstrating how inherited ELP1 variants confer risk for SHH #medulloblastoma! tinyurl.com/39p365ae
Congratulations to the Northcott team making the cover of Cancer Cell for their work demonstrating how inherited ELP1 variants confer risk for SHH #medulloblastoma! tinyurl.com/39p365ae
New research reveals how ELP1 germline deficiency predisposes children to SHH-medulloblastoma and identifies a promising targeted therapy: MDM2 inhibitors. These findings may form the basis for adding MDM2 inhibition to clinical trials for SHH-medulloblastoma.
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