Sable Systems International 🐭🐀🧝🏼♀️ @SableSys
Thoughts, visions & revisions from John Lighton PhD, president & CIO of Sable Systems International (=the world's most advanced metabolic measurement systems) sablesys.com Nevada & Washington, USA Joined June 2009-
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Sable Systems International 🐭🐀🧝🏼♀️ retweeted
The larger problem is amnesia Modern societies treat vaccines as heavy interference rather than the backbone of eradication The choice is rarely framed honestly Not freedom vs control but collective action vs relapse History shows what happens when the contract fractures
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Sable Systems International 🐭🐀🧝🏼♀️ retweeted
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
Animal models remain essential in several areas of biomedical and scientific research where alternatives cannot yet fully replicate whole-organism complexity. For eg: Neurological disorders (e.g., Alzheimer’s, Parkinson’s, ALS) where brain complexity and systemic interactions…
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
Whole organisms let us see how a treatment works across systems: the immune system, metabolism, hormones, the brain. A cancer drug may look promising in a dish, but how does it affect the heart, or the liver? Only an intact organism can help elucidate that.
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
Despite the incredible rise of computational models, cell cultures, and organ-on-a-chip systems, biology is still more complex than any lab bench or supercomputer can fully capture.
A really important thread 👋👇
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
I totally get the sensitivities of the public around the use of animals for research. In fact it is partly why I pivoted careers. HOWEVER the public campaign launched against it by influencers miss very important considerations which are critical for the public to know ⬇️
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
why we need animal models - do we sometimes rely too much on mouse models, yes, but can we 100% replace them with chips, organoids, and studies in humans - no
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
The “problem” with vaccines? They so effective at preventing deaths that they create generations of people that question whether disease was a problem in the first place because they have never experienced the horrors of a world without vaccines.
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
Does your #lab conduct #respirometry studies on ruminants? Check out this #OnDemand #webinar from Dr. Juan Ku-Vera, who discusses respiration chambers for measuring #methane emissions in ruminants. ow.ly/KCKH50WR7Mr #Livestock #Ruminant #DairyIndustry #GreenhouseGas
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
The fifth horseman
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
🧪 Need standardized testing for your mouse models? MMPC offers a variety of assays to support your research. Browse our catalog today: mmpc.org/catalog #MouseModels #ScientificResearch
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
🎉 Big congrats to Zhe Wu of Michigan MMPC-Live for winning the 2025 Research Cores Staff Recognition Award! “Zhe’s expertise and dedication have been essential for our success.” – Carol Elias, PhD #behindthelab #UMICHMMPC
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
Could oleocanthal (OC), an #anti-inflammatory component of Extra Virgin #OliveOil, protect against #Alzheimers disease? With help from Promethion #Metabolic Cages, scientists found improved metabolic phenotypes in OC-treated 5xFAD Alzheimer's model mice. ow.ly/W6vr50WPJeZ
Congratulations, Peter!!
Sable Systems International 🐭🐀🧝🏼♀️ retweeted
We built norn.group/bigpicture to be a clear and concise map of opportunities in the aging field. Warning: you may spend more time exploring here than you initially anticipate...
We built norn.group/bigpicture to be a clear and concise map of opportunities in the aging field. Warning: you may spend more time exploring here than you initially anticipate...
More impactful Promethion‑powered research from Dr. O MacDougald & colleagues at the University of Michigan - FGF21 + sTGFBR2 gene therapy eases lipodystrophic insulin resistance, temperature‑dependently. insight.jci.org/articles/view/…
More impactful Promethion‑powered research from Dr. O MacDougald & colleagues at University of Michigan - FGF21 + sTGFBR2 gene therapy eases lipodystrophic insulin resistance, temperature‑dependently! insight.jci.org/articles/view/…
More forward‑looking Promethion‑powered science from Dr. M Hjorth & colleagues at University of Oslo - decorin deficiency leaves adiposity, glucose tolerance & VO₂ unchanged in mice! physoc.onlinelibrary.wiley.com/doi/10.14814/p…
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jimternyila / infinit... @jimternyila
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