(1/12) Over a year ago, we launched a new project to explore whether the tissue microenvironment could predict cellular behaviour and whether reprogramming might unlock new therapeutic avenues. 🧬 Spatial transcriptomics provides deep insights into tissue organisation.
We…
A new study from NYU Langone outlines a potential AI-based method to help track aging cells. The tool assigns a “senescence score” based on nuclear features, which may aid future research in aging and disease.
🧬 Read: doi.org/10.1038/s41467…
Update on a new interpretable decomposition method for LLMs -- sparse mixtures of linear transforms (MOLT). Preliminary evidence suggests they may be more efficient, mechanistically faithful, and compositional than existing techniques like transcoders transformer-circuits.pub/2025/bulk-upda…
We're launching an "AI psychiatry" team as part of interpretability efforts at Anthropic! We'll be researching phenomena like model personas, motivations, and situational awareness, and how they lead to spooky/unhinged behaviors. We're hiring - join us! job-boards.greenhouse.io/anthropic/jobs…
How challenging is the prediction of transcriptional responses to CRISPR gene perturbations ?
A simple model, just scaling RNA correlation vectors, results in accurate predictions for many perturbations.
The model is intuitive & grounded in a simple approximation.
1/2
Evo 2 update: new dependency versions (torch, transformer engine, flash attn) and a docker option mean it should be easy to setup without needing to compile locally.
Happy ATGC-ing!
github.com/ArcInstitute/e…
Here is a fascinating essay outlining Markov Bio's thesis: foundation models based on observational scRNA data are severely underrated. They got a bad initial reputation, but early models had big problems: too small, weird architectures, and more.
markov.bio/research/mech-…
Here is a fascinating essay outlining Markov Bio's thesis: foundation models based on observational scRNA data are severely underrated. They got a bad initial reputation, but early models had big problems: too small, weird architectures, and more.
markov.bio/research/mech-…
1/ You're not just sequencing single cells.
You're sequencing the soup they're in.
Ambient RNA is everywhere in single-cell RNA-seq. Here's how to fix it.
Design Of Intrinsically Disordered Region Binding Proteins @ScienceMagazine
🚀 New paper published from David Baker!🚀
A groundbreaking computational approach has been developed to design proteins that can specifically bind to intrinsically disordered regions (IDRs), which are…
Spatial biology is moving quickly and offers much to be excited about.
But there is still a big learning curve. Especially with analysis.
If you are a scientist new to spatial techniques, how do you actually analyze your data? A concrete tutorial from prep to insight follows:
Hey smart people out there, what structure does this protein fold into? Hint: AlphaFold, ESMFold, Boltz, Chai, etc are wrong 🤭. Good luck!
>whatami
MKIAVIGATGQVGREIAKLLAEKGHEVTAIASRSKNPEEVAKLGIEAVYVDGEVLDFKSVEEAVKNADVVISVAGG
So, exercise is anti-cancer
This is partly because exercise boosts the immune system - killer T cells - and this seems to be because of Formate production by gut bacteria
No MSA? 🔥 No problem🔎
PLAME turns ESM-2 embeddings into virtual MSAs, HiFiAD-filters them and lifts pLDDT +5 on zero-shot CASP14 targets
AlphaFold2 accuracy at near-ESMFold latency🔥
1K Followers 2K FollowingStatistician and computational biologist; alum @maehrlab, @cahanlab, @alexisjbattle lab. Views are not those of my employer. He/him. https://t.co/jaMuFiHjk0
109K Followers 1 FollowingClaude is an AI assistant built by @anthropicai to be safe, accurate, and secure. Talk to Claude on https://t.co/ZhTwG8dz3D or download the app.
2K Followers 669 FollowingThe official account of Spencer S. Eccles Health Sciences Library, @UUtah. We advance and transform education, research, and health care.
Questions? Ask us!
3K Followers 675 FollowingProfessor at Johns Hopkins University. Working to prevent cancer from spreading and becoming resistant to therapy. @[email protected]
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2K Followers 73 FollowingFounded by Lena Yu aka @LambdaMamba | Run by World Cyber Health (WCH) Non-Profit | Discord: https://t.co/JE25nRRco6 | Email: [email protected]
3K Followers 56 FollowingDyno Therapeutics is a pioneer in applying artificial intelligence to gene therapy, focused on AAV capsid engineering. Join our startup: https://t.co/Qw1SEcTjpp
41K Followers 2K FollowingDirector of bioinformatics at AstraZeneca. YouTube at chatomics. On my way to helping 1 million people learn bioinformatics. Also talks about leadership.
1K Followers 2K FollowingStatistician and computational biologist; alum @maehrlab, @cahanlab, @alexisjbattle lab. Views are not those of my employer. He/him. https://t.co/jaMuFiHjk0
3K Followers 1K FollowingChair @la_UPC IcreaAcademia @icreacommunity @adw_goe @unigoettingen @CRMatematica @AvHStiftung @UniCologne
living in a "mote of dust suspended in a sunbeam".
544 Followers 2 FollowingTamarind is a web app and API for the leading protein design tools, trusted by tens of thousands of industry scientists including many global top 20 biopharma.
2K Followers 863 FollowingAssociate Prof of Medicine in Cardiology, Johns Hopkins, wife of heart failure leader + mom of 2, CMR research, Medical Director of Echo, ASE BOD, SCMR past BOD
6K Followers 192 FollowingOur lab focuses on genetic changes in cancer and how they contribute to tumorigenesis in the hope of finding therapeutic targets. Tweets from Scott signed -SWL.
7K Followers 654 FollowingDepartment of Biomedical Informatics at @Harvard/@harvardmed: #datascience- & #AI/#ML-powered models of clinical care to advance human health. Chair @zakkohane.
13K Followers 2K FollowingSVP and Head of Biomedical AI @Xaira_Thera; Associate Prof @UofT; Chief AI Officer @UHN; former PHD, CS @Stanford; opinions my own. #AI #healthcare #biology
30K Followers 510 FollowingObstetrics & Gynecology (the Green Journal) has been the official publication of the American College of Obstetricians and Gynecologists since 1953.
907 Followers 21 FollowingAn integrated biotechnology company driving advances in artificial intelligence to learn the language of life and transform how we treat disease
2K Followers 1K FollowingProf of Medicine & Assoc Chief of Basic Research @UofUHematology @UofUInternalMed @UU_MolecularMed @UofUMandI Hematopoiesis, immunology, development
162K Followers 891 FollowingThe official Twitter feed for Yale School of Medicine, a world-renowned center for biomedical research, education, and health care founded in 1810.
9K Followers 973 FollowingPhD student @Cambridge_CL. Research Intern @AIatMeta and @PrescientDesign. Interested in Deep Learning for biomolecule design.
1K Followers 1K FollowingBiologist that navigates in the oceans of diversity through the space-time |
MSc in Biochem/Bioinfo @ibt_unam 🇲🇽 |
Protein evo, metagenomics & AI/ML/DL