Spektor Lab @SpektorLab
Joined December 2018-
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#Radonc physician-scientists, you’re invited to the ELEVENTH annual #CROPS 🌽 happy hour!! Tuesday 10/1 6:30-8:30 pm at bartaco, 1025 5th St NW. Come by for any part. Pls RSVP if you think you can join us. Looking forward to seeing everyone!! #ASTRO24 @ASTRO_org @ARRO_org
Terrific session dedicated to the memory of Angelika Amon, with a tribute by @JSheltzer and outstanding talks by @JSheltzer, @ZStorchova, @SteSantaguida and others. #ANESRC
Terrific session dedicated to the memory of Angelika Amon, with a tribute by @JSheltzer and outstanding talks by @JSheltzer, @ZStorchova, @SteSantaguida and others. #ANESRC
Excited to welcome aneuploidy scientific community in sunny Melbourne, FL. Can't wait to see everyone. #ANESRC
Because CDK5 is overexpressed in many cancers and is associated with a poor prognosis, our study raises the possibility that these cancers may be more dependent on CDK5 for their cell division and suggests that CDK5 may be an important therapeutic target.
The study alters the existing paradigm that CDK1-Cyclin B1 is the only CDK-cyclin complex essential for all stages of mitosis and raises the possibility that other atypical CDKs may also have a role in regulating the cell-division cycle.
Loss of CDK5-Cyclin B1 interaction abolished CDK5 activity in vitro (thanks to our collaborator Kavita Shah) and phenocopied CDK5 abrogation in mitosis. CDK5–cyclin B1 is thus a canonical CDK–cyclin complex that plays an essential role in maintaining genome integrity.
Surprisingly, we discovered that CDK5 forms a functional complex with Cyclin B1, the mitotic cyclin that partners with CDK1 to complete all stages of mitosis.
With the help of our collaborator @AmandaPaulovich, we used phosphoproteomic analysis to identify putative CDK5 substrates that may account for this phenotype.
Using two orthogonal chemical genetic approaches, we show that CDK5, an atypical CDK essential in non-dividing neuronal cells, plays an important role in mitosis in preventing mitotic errors. Abrogation of CDK5 prior to mitosis led to chromosome mis-segregation and nuclear atypia
We found that these errors occur because spindle microtubules that separate sister chromatids during mitosis become abnormally stable in the absence of CDK5, preventing cells from correcting chromosome attachment errors.
Cyclin Dependent Kinases (CDKs) are critical for regulating different phases of the cell cycle and CDK1 was considered to be the only CDK essential mitosis.
(1/5) I am delighted to share our study published today @Nature nature.com/articles/s4158… collaboration with @chowdhury Lab, led by @XiaoZheng3and @aniruddhSark. Huge congratulations to all the authors and collaborators.
We want your research at #ANESCR to help organizers @GodekLab, @LabSpektor, and more unpack the Consequences of Aneuploidy. Submit your abstract by July 21 and save your space: hubs.ly/Q02FjvPq0
Abstract deadline coming up! Hurry and register to the FASEB "Consequences of Aneuploidy" meeting in Florida (Sep 15-19). This meeting gathers top scientists studying chromosomes, cancer genomes, mitosis and meiosis, and more. More details: events.faseb.org/event/conseque…
My apologies the word artistic I meant self-absorbed, and I apologize again
#Radonc physician-scientists, join us for the annual #CROPS 🌽 happy hour!! Tues 10/25 6-8 pm, River’s Edge Cafe in the Hilton Palacio del Rio. Come by for any part. Pls RSVP if you think you can join us. Looking forward to seeing everyone in person! #ASTRO22 @ASTRO_org @ARRO_org
What better way to get to know us than through the eyes of our residents? Join us on 9/28 or 10/11 for a virtual meet & greet! Get all your questions answered about #HROP #RadOnc Sign up here: surveymonkey.com/r/JQB5BN6
#ANEUPLOIDY22 It was truly a fantastic meeting and a wonderful tribute to Angelika. Thank you @SteSantaguida, @JSheltzer, Eduardo Torres and Beth Weaver for making this possible. Hoping to see everyone again in 2 years.
Today at #ANEUPLOIDY22: replication defects and their link to chromosome instability (and vice versa), centrosome amplification, how chromosomal instability relates to efficacy of cancer treatments, how to reliably measure chromosome instability.
YU~~🎊🇺🇸🎀�... @judy_baca33478
242 Followers 669 Following Your attitude, not your aptitude, will determine your altitude
Tharun @Adusumilli_18
25 Followers 2K Following
Dan Rosen @DanielBRosen
234 Followers 971 Following Radiation oncology resident @harvard_radonc @harvard_med | MD -PhD @WeillCornell @RockefellerUniv @TriIMDPhD | Cal Alum @UCBerkeley| views = mine
Journal of Clinical I... @jclinicalinvest
51K Followers 4K Following The JCI is a premiere venue for discoveries in basic & clinical biomedical science. Est. 1924- https://t.co/xG7OGiBetO Bluesky: https://t.co/jMpYqQZxOk
Meng Xu Welliver @DrMengWelliver
216 Followers 849 Following Radiation Oncologist, #Experimental Therapeutics @astro_org @ABR_Radiology @rsna @MayoClinic @MayoRadOnc @OSUCCC_James @PennRadOnc Opinions are my own
Amy Wisdom, MD, PhD @AmyWisdom8
565 Followers 317 Following Radiation oncology resident @harvardradonc | MD PhD @dukeMSTP | @ucla alum
Yiannis (Ioannis) Ver... @YVerginadis
218 Followers 398 Following Research Assistant Professor, @Penn @PennRadOnc
David Yang @DYangMD
317 Followers 429 Following Radiation Oncologist at @DanaFarber @BrighamWomens @harvardmed and Research Fellow in @VanAllenLab. All views are my own.
Genomic Instability a... @FMachinLab
515 Followers 652 Following PhD Félix Machín (@MachinPhd) Laboratory Official X Account. We do science with yeast and more, especially interested in chromosome stability and cell cycle.
Liang Sha @LiangSha_Liam
17 Followers 90 Following Instructor of research medicine at USC Keck. Biochemist and cell biologist. Interested in chromosomal instability and chromatin biology.
Sue Biggins @SueBiggins
4K Followers 1K Following Scientist at @FredHutch @HHMINews. Interdisciplinary approaches to understanding chromosomes and cell division. Opinions are my own. (She/her)
Sarah Aitken @S_J_Aitken
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Vincenzo DAngiolella @VdangioE3lab
1K Followers 1K Following The laboratory is investigating the role of ubiquitin system in cancer pathogenesis and response to treatment with ionising radiation.
Alexander Goginashvil... @Al_Goginashvili
18 Followers 565 Following
Ksenia Krupina @quintatoen
56 Followers 92 Following Postdoctoral fellow, Don Cleveland lab @UCSanDiego. DNA damage, genomic rearrangements, chromothripsis. Photographer in my free time.
Emma V. Watson @game_of_chroms
562 Followers 625 Following Assistant Professor @UMassChan Dept. of Systems Biology. Former Postdoc/Instructor @BWHGenetics & @harvardmed. Cancer Chromosome Genetics!
Peter Ly @PeterLyLab
2K Followers 581 Following Genome Integrity Lab | Assistant Professor @UTSWMedCenter. We study how chromosomes segregate, break, and rearrange. @peterlylab.bsky.social
Ruxandra Lambuta @RuxandraLambuta
847 Followers 424 Following Chocolate explorer and science Padawan @imbmainz. 🇷🇴n in 🇩🇪.
Andreas Panagopoulos @APanagopoulos_
868 Followers 2K Following Postdoc @altmeyerlab. Interested in Checkpoint maintenance, DNA replication, DNA repair & Imaging.
Nikoleta Pateraki @NikolPateraki
151 Followers 700 Following PhD student at @imbmainz, interested in #RNA, #transcription, #DNAdamage,#aneuploidy and more.. alumna: @uoc_gr , @IMBB_FORTH
Zuzanna Nowicka @zuzannows
164 Followers 276 Following MD, during PhD in Department of Biostatistics and Translational Medicine in Łódź, Poland | Hematology resident | statistics & cancer
Achyut Bora @AchyutBora14
56 Followers 372 Following #Ph.D. Biological Sciences #Cancer_Biologist #DNA_Damage_Response #Nucleic_Acids_Research #CSIR- Indian Institute of Chemical Biology! Kolkata! India
Kent Mouw @mouwlab
1K Followers 578 Following Radiation oncology physician-scientist @danafarber @brighamwomens Associate Professor @harvardmed #DNArepair #bladdercancer #prostatecancer
Chowdhury Lab @ChowdhuryLab
2K Followers 334 Following The Chowdhury lab studies #DSBrepair, #RadiationOncology & #microRNAs as biomarkers @Harvardmed @DanaFarber @BrighamWomens. Account managed by lab members.
@weitinglu.bsky.socia... @Wtlu3
333 Followers 867 Following Tea addict and scientist, in that order. Incoming Group Leader, Dept of Oncology, University of Oxford. All views my own.
Anindita Saha @asaha_reeti
124 Followers 519 Following ~To live while you are alive, and die only when you are dead~🌻
Ben-David Lab @BenDavidLab
688 Followers 216 Following Investigating #aneuploidy in #cancer 🧬 @TelAvivUni
Daniele Fachinetti @FachinettiLab
2K Followers 521 Following Molecular and cell biologist in love with chromosomes
CH JEFF @ChJeffch23
1 Followers 161 Following
Freddy E Escorcia (@f... @freddyeescorcia
4K Followers 3K Following Physician-scientist · Cancer imaging & therapy · Radiopharmaceuticals · #radonc · Tweets=own
Ralph Weichselbaum @rweichselbaum
5K Followers 5K Following
Heather McGee, MD PhD @HMcGeeMDPhD
315 Followers 199 Following Radiation Oncologist, Immunologist, Physician-Scientist @cityofhope, views my own
Varun Chowdhry, MD, M... @VarunChowdhryMD
374 Followers 869 Following Radiation Oncologist, Dad, health ops/policy, Samastha Lokah Sukhino Bhavantu, #LoveAllServeAll, success is helping others, views =my own, not medical advice
Zach Morris @ZachMorrisMDPhD
237 Followers 218 Following Family man with a physician-scientist habit. Views are my own.
Erik Blomain @BlomainMDPhD
369 Followers 392 Following RadOnc Physician Scientist @JeffersonUniv, @StanfordRadOnc Grad, @NCCN Patient Advocate, SyFy author, Dog Dad #BelgianMalinois, #PhillySports, Tweets are my own
Ellen @EllenKimMD
983 Followers 1K Following Clinical informatician & radonc @BrighamRadOnc @DanaFarber
Chenhui Deng @chenhui_deng
62 Followers 86 Following Biotech | Stem Cells | PhD in Biochem and Cell Bio 🎓 @MCBDartmouth | 🧬🔬👨🏻🔬| 🇨🇳➡️🇦🇺 ➡️🇺🇸 | He/Him
Klaske M. Schukken, P... @DrKlaske
157 Followers 141 Following Postdoc at #YaleUniversity, I study the effects of #Aneuploidy on #cancer.
Ofer Shoshani @ShoshaniOfer
300 Followers 169 Following Cell biologist studying chromosomes in health and disease. PI at the Weizmann Institute of Science.
Fernando Monje-Casas @FMC_lab
458 Followers 274 Following Fernando Monje-Casas Laboratory Official Twitter Account
Samuel Bakhoum @Samuel_Bakhoum
3K Followers 1K Following #Physician_Scientist interested in #Chromosomal_Instability, #aneuploidy, and #cancer views expressed are my own
Geng-yuan Chen @asdScott0331
191 Followers 540 Following Postdoc in the Lampson lab at Penn. Current focus: chromosome segregation and underlying mechanics.
susanagodinho.bsky.so... @godinho_susana
2K Followers 998 Following Cell Biologist at BCI-QMUL. Likes tiny centrosomes but only when amplified! Lab studies how abnormal microtubules and centrosomes alter cell physiology.
Jake June-Koo Lee @jakelee0711
1K Followers 1K Following Physician Scientist @CompOncMSK and Thoracic Oncologist @MSKCancerCenter Historian of Cancer Genomes | Chromosome Biology | Therapy Resistance
Nataliia Serbyn @nat_serbyn
154 Followers 229 Following Molecular geneticist in the Pellman lab; @LabStutz PhD alumni.
Andrea (Didi) Gardner @AndreaLGardner
421 Followers 445 Following Cell-cell fusion enthusiast researching tumor heterogeneity with single cell technologies and math modeling. Postdoc w/ @AmyBrock UT Austin.
Pan Cheng @chengpan_cp
147 Followers 630 Following PhD student @NYUMed Teresa Davoli lab, studying the consequences and weaknesses of aneuploidy in the context of cancer biology.
Pippa Cosper MD, PhD @pipcosper
3K Followers 971 Following Scientist, Radiation Oncologist, pipetting for life (literally and figuratively). WashU RadOnc, Assistant Prof at UW Madison. Chromosomal instability is my jam
Journal of Clinical I... @jclinicalinvest
51K Followers 4K Following The JCI is a premiere venue for discoveries in basic & clinical biomedical science. Est. 1924- https://t.co/xG7OGiBetO Bluesky: https://t.co/jMpYqQZxOk
Dan Rosen @DanielBRosen
234 Followers 971 Following Radiation oncology resident @harvard_radonc @harvard_med | MD -PhD @WeillCornell @RockefellerUniv @TriIMDPhD | Cal Alum @UCBerkeley| views = mine
David Yang @DYangMD
317 Followers 429 Following Radiation Oncologist at @DanaFarber @BrighamWomens @harvardmed and Research Fellow in @VanAllenLab. All views are my own.
Yiannis (Ioannis) Ver... @YVerginadis
218 Followers 398 Following Research Assistant Professor, @Penn @PennRadOnc
Freddy E Escorcia (@f... @freddyeescorcia
4K Followers 3K Following Physician-scientist · Cancer imaging & therapy · Radiopharmaceuticals · #radonc · Tweets=own
Mohamed Abazeed, MD, ... @theabzlab
2K Followers 733 Following Professor and Chair | Radiation Oncologist | @NorthwesternMed | My views |
Iva Tolić @Toliclab
3K Followers 848 Following Moved to https://t.co/qqX1gi2P81! Biophysics of Mitosis @institutrb, @EMBO member; Ex Group Leader @mpicbg, PD @UNI_FIRENZE, @uni_copenhagen, PhD @PMFZAGREB
Elsa Logarinho @ELogarinho
898 Followers 580 Following Group Leader @i3S Aging & Aneuploidy Lab. Targeting #genomic instability in #aging. #Rejuvenation. #Longevity. #Progeria and #Down syndromes.
Aadel Chaudhuri, MD P... @aadel_chaudhuri
3K Followers 833 Following Professor & Vice Chair for Translational Research @MayoRadOnc | Co-Director of Cancer Precision Medicine @MayoClinic | Co-Founder @liquidcelldx & @DropletBiosci
Genomic Instability a... @FMachinLab
515 Followers 652 Following PhD Félix Machín (@MachinPhd) Laboratory Official X Account. We do science with yeast and more, especially interested in chromosome stability and cell cycle.
Marco Milan @MarcoMilanIRB
2K Followers 595 Following Group Leader @IRBBarcelona @ICREACommunity @EMBO member. Interests: Drosophila, Growth control, Chromosomal Instability, Aneuploidy & many other topics.
Sarah Aitken @S_J_Aitken
2K Followers 1K Following Assistant Professor @YaleCancer Center & @YalePathology • @CR_UK Clinician Scientist Pathologist @Cambridge_Uni • @aitken_lab • post≠employer #GenomicPathology
Sue Biggins @SueBiggins
4K Followers 1K Following Scientist at @FredHutch @HHMINews. Interdisciplinary approaches to understanding chromosomes and cell division. Opinions are my own. (She/her)
Ksenia Krupina @quintatoen
56 Followers 92 Following Postdoctoral fellow, Don Cleveland lab @UCSanDiego. DNA damage, genomic rearrangements, chromothripsis. Photographer in my free time.
Emma V. Watson @game_of_chroms
562 Followers 625 Following Assistant Professor @UMassChan Dept. of Systems Biology. Former Postdoc/Instructor @BWHGenetics & @harvardmed. Cancer Chromosome Genetics!
Ruxandra Lambuta @RuxandraLambuta
847 Followers 424 Following Chocolate explorer and science Padawan @imbmainz. 🇷🇴n in 🇩🇪.
Vincenzo DAngiolella @VdangioE3lab
1K Followers 1K Following The laboratory is investigating the role of ubiquitin system in cancer pathogenesis and response to treatment with ionising radiation.
Andreas Panagopoulos @APanagopoulos_
868 Followers 2K Following Postdoc @altmeyerlab. Interested in Checkpoint maintenance, DNA replication, DNA repair & Imaging.
Nikoleta Pateraki @NikolPateraki
151 Followers 700 Following PhD student at @imbmainz, interested in #RNA, #transcription, #DNAdamage,#aneuploidy and more.. alumna: @uoc_gr , @IMBB_FORTH
Zuzanna Nowicka @zuzannows
164 Followers 276 Following MD, during PhD in Department of Biostatistics and Translational Medicine in Łódź, Poland | Hematology resident | statistics & cancer
Aniruddha Sarkar PhD @aniruddhSark
213 Followers 1K Following Research fellow at Dana-Farber cancer institute/Harvard Medical School
Bartek Tomasik @B_Tomasik
232 Followers 338 Following Physician trying to kill bad cells faster than good ones and do some science ☢️🔬
Achyut Bora @AchyutBora14
56 Followers 372 Following #Ph.D. Biological Sciences #Cancer_Biologist #DNA_Damage_Response #Nucleic_Acids_Research #CSIR- Indian Institute of Chemical Biology! Kolkata! India
Chowdhury Lab @ChowdhuryLab
2K Followers 334 Following The Chowdhury lab studies #DSBrepair, #RadiationOncology & #microRNAs as biomarkers @Harvardmed @DanaFarber @BrighamWomens. Account managed by lab members.
@weitinglu.bsky.socia... @Wtlu3
333 Followers 867 Following Tea addict and scientist, in that order. Incoming Group Leader, Dept of Oncology, University of Oxford. All views my own.
Kent Mouw @mouwlab
1K Followers 578 Following Radiation oncology physician-scientist @danafarber @brighamwomens Associate Professor @harvardmed #DNArepair #bladdercancer #prostatecancer
Susanne Lens @LensSusanne
422 Followers 102 Following
Ben-David Lab @BenDavidLab
688 Followers 216 Following Investigating #aneuploidy in #cancer 🧬 @TelAvivUni
Peter Ly @PeterLyLab
2K Followers 581 Following Genome Integrity Lab | Assistant Professor @UTSWMedCenter. We study how chromosomes segregate, break, and rearrange. @peterlylab.bsky.social
Alison M. Taylor @alisontaylorlab
445 Followers 151 Following Scientist, assistant professor at Columbia University Medical Center studying aneuploidy in cancer, posts are my own and do not represent views of CUIMC
Daniele Fachinetti @FachinettiLab
2K Followers 521 Following Molecular and cell biologist in love with chromosomes
Jason Sheltzer @JSheltzer
17K Followers 2K Following Assistant prof at @StanfordMed. Interested in aneuploidy, mitotic kinases, cancer therapeutics, and drug development. Co-founder x2.
Stamatis Papathanasio... @stambio
258 Followers 303 Following Group Leader, Institute of Molecular Biology, Mainz @stambio.bsky.social
Ralph Weichselbaum @rweichselbaum
5K Followers 5K Following
Søren M Bentzen @SorenBentzen
3K Followers 101 Following Professor of Epidemiology and Public Health, Professor of Radiation Oncology, Director of Biostatistics, University of Maryland School of Medicine 🇺🇸🇬🇧🇩🇰
Max Diehn, MD/PhD @max_diehn
2K Followers 364 Following Radiation oncologist & physician scientist @Stanford. Lung cancer, liquid biopsy, diagnostics
Heather McGee, MD PhD @HMcGeeMDPhD
315 Followers 199 Following Radiation Oncologist, Immunologist, Physician-Scientist @cityofhope, views my own
The Center for BRCA a... @DanaFarberBRCA
131 Followers 44 Following The Center for #BRCA and Related Genes at @DanaFarber helps uncover new treatments for patients with #BRCA and BRCA related cancers
Erik Blomain @BlomainMDPhD
369 Followers 392 Following RadOnc Physician Scientist @JeffersonUniv, @StanfordRadOnc Grad, @NCCN Patient Advocate, SyFy author, Dog Dad #BelgianMalinois, #PhillySports, Tweets are my own
Penn Center for Genom... @PennGenomeInteg
381 Followers 220 Following PCGI's mission is to integrate cutting-edge research in basic and clinical sciences to advance our understanding of genome integrity.
Ellen @EllenKimMD
983 Followers 1K Following Clinical informatician & radonc @BrighamRadOnc @DanaFarber
Chenhui Deng @chenhui_deng
62 Followers 86 Following Biotech | Stem Cells | PhD in Biochem and Cell Bio 🎓 @MCBDartmouth | 🧬🔬👨🏻🔬| 🇨🇳➡️🇦🇺 ➡️🇺🇸 | He/Him
Klaske M. Schukken, P... @DrKlaske
157 Followers 141 Following Postdoc at #YaleUniversity, I study the effects of #Aneuploidy on #cancer.
Varun Chowdhry, MD, M... @VarunChowdhryMD
374 Followers 869 Following Radiation Oncologist, Dad, health ops/policy, Samastha Lokah Sukhino Bhavantu, #LoveAllServeAll, success is helping others, views =my own, not medical advice
Jake June-Koo Lee @jakelee0711
1K Followers 1K Following Physician Scientist @CompOncMSK and Thoracic Oncologist @MSKCancerCenter Historian of Cancer Genomes | Chromosome Biology | Therapy Resistance
Ofer Shoshani @ShoshaniOfer
300 Followers 169 Following Cell biologist studying chromosomes in health and disease. PI at the Weizmann Institute of Science.
Geng-yuan Chen @asdScott0331
191 Followers 540 Following Postdoc in the Lampson lab at Penn. Current focus: chromosome segregation and underlying mechanics.
susanagodinho.bsky.so... @godinho_susana
2K Followers 998 Following Cell Biologist at BCI-QMUL. Likes tiny centrosomes but only when amplified! Lab studies how abnormal microtubules and centrosomes alter cell physiology.Trends for United States
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