Building on our previous post about the Taipale lab’s work, 16% of pathogenic variants are linked to protein mislocalization, disrupting stability, especially in the secretory pathway. 🧬 Variants with distinct localization patterns are tied to different disease outcomes. 🧵
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Explore this dataset on Spring Science to drive new discoveries! Read the publication in Cell: buff.ly/4eWrtwk Visit buff.ly/486on6P to access the data. #ProteinMislocalization #SpringScience #LifeSciences #DataSharing